20 clusters with significant GO annotations Cluster 1: 2 genes GO term [253]: biological_process 0.00e+000 categ GO cluster 1 1 microarray 1907 1908 GO term [255]: biosynthesis 0.00e+000 categ GO cluster 1 1 microarray 371 1908 GO term [342]: cell 0.00e+000 categ GO cluster 1 1 microarray 1680 1908 GO term [387]: cellular_component 0.00e+000 categ GO cluster 1 1 microarray 1908 1908 GO term [515]: cytoplasm 0.00e+000 categ GO cluster 1 1 microarray 1081 1908 GO term [526]: cytosol 0.00e+000 categ GO cluster 1 1 microarray 202 1908 GO term [527]: cytosolic large ribosomal subunit (sensu Eukarya) 0.00e+000 categ GO cluster 1 1 microarray 61 1908 GO term [528]: cytosolic ribosome (sensu Eukarya) 0.00e+000 categ GO cluster 1 1 microarray 118 1908 GO term [769]: Gene_Ontology 0.00e+000 categ GO cluster 1 1 microarray 1908 1908 GO term [985]: intracellular 0.00e+000 categ GO cluster 1 1 microarray 1502 1908 GO term [1039]: large ribosomal subunit 0.00e+000 categ GO cluster 1 1 microarray 76 1908 GO term [1098]: macromolecule biosynthesis 0.00e+000 categ GO cluster 1 1 microarray 299 1908 GO term [1151]: metabolism 0.00e+000 categ GO cluster 1 1 microarray 1062 1908 GO term [1242]: molecular_function 0.00e+000 categ GO cluster 1 1 microarray 1907 1908 GO term [1617]: physiological process 0.00e+000 categ GO cluster 1 1 microarray 1480 1908 GO term [1716]: protein biosynthesis 0.00e+000 categ GO cluster 1 1 microarray 212 1908 GO term [1737]: protein metabolism 0.00e+000 categ GO cluster 1 1 microarray 418 1908 GO term [1984]: ribonucleoprotein complex 0.00e+000 categ GO cluster 1 1 microarray 199 1908 GO term [2000]: ribosome 0.00e+000 categ GO cluster 1 1 microarray 150 1908 GO term [2182]: structural constituent of ribosome 0.00e+000 categ GO cluster 1 1 microarray 133 1908 GO term [2183]: structural molecule activity 0.00e+000 categ GO cluster 1 1 microarray 168 1908 + 0.000000 - 0.884510 RPL7B [253 255 342 387 515 526 527 528 769 985 1039 1098 1151 1242 1617 1716 1737 1984 2000 2182 2183] 60S large subunit ribosomal protein + 0.000000 - 0.464283 YML089C questionable ORF Cluster 2: 18 genes GO term [1085]: lyase activity 3.17e-005 categ GO cluster 4 16 microarray 24 1908 GO term [305]: carbon-carbon lyase activity 3.95e-005 categ GO cluster 3 16 microarray 9 1908 GO term [1516]: oxo-acid-lyase activity 1.97e-004 categ GO cluster 2 16 microarray 3 1908 GO term [319]: carboxy-lyase activity 9.70e-004 categ GO cluster 2 16 microarray 6 1908 TF NDD1 (3 / 82 16.67%) protein required for nuclear division KGD2 YML101C YMR144W TF MBP1 (2 / 99 11.11%) "transcription factor, subunit of the MBF factor" YML101C YMR144W TF MCM1 (2 / 73 11.11%) transcription factor of the MADS box family KGD2 YLR261C TF SWI4 (2 / 116 11.11%) transcription factor YML101C YMR144W TF SWI5 (2 / 84 11.11%) transcription factor GPR1 YML101C TF SUM1 (2 / 48 11.11%) suppressor of SIR mutations ECM8 SRL2 TF FKH2 (2 / 92 11.11%) homology to D.melanogaster forkhead protein KGD2 YMR144W + 0.000627 - 0.404608 YML101C weak similarity to YMR264w + 0.000518 - 0.404509 YMR144W weak similarity to Mlp1p + 0.404345 - 0.000353 SRL2 weak similarity to phospholipase C + 0.000369 - 0.404336 ECM8 involved in cell wall structure or biosynthesis + 0.404185 - 0.000190 MCM22 required for maintenance of chromosomes and minichromosomes + 0.000172 - 0.404154 ICL1 [305 1085 1516] isocitrate lyase + 0.046625 - 0.000000 YOR342C weak similarity to YAl037w + 0.000056 - 0.039111 YNR070W strong similarity to Snq2p + 0.036768 - 0.000059 HEM12 [305 319 1085] uroporphyrinogen decarboxylase + 0.033777 - 0.000000 CSI2 involved in chitin synthesis + 0.032620 - 0.000415 GPR1 G-protein coupled receptor + 0.031731 - 0.000081 YLR261C questionable ORF + 0.031404 - 0.000102 RPL33A ribosomal protein L35a.e.c16 + 0.026291 - 0.000483 KGD2 2-oxoglutarate dehydrogenase complex E2 component + 0.000037 - 0.023939 YGL074C questionable ORF + 0.020005 - 0.000050 SPT14 N-acetylglucosaminyltransferase + 0.018343 - 0.000000 STR3 [1085] strong similarity to Emericella nidulans and similarity to other cystathionine beta-lyase and Cys3p + 0.015948 - 0.000000 TRP3 [305 319 1085 1516] anthranilate synthase component II Cluster 3: 12 genes GO term [368]: cell wall 1.54e-004 categ GO cluster 3 5 microarray 49 1908 GO term [369]: cell wall (sensu Fungi) 1.54e-004 categ GO cluster 3 5 microarray 49 1908 GO term [703]: external encapsulating structure 1.54e-004 categ GO cluster 3 5 microarray 49 1908 TF PDR1 (2 / 53 16.67%) transcription factor FIG1 YLR465C TF SWI4 (2 / 116 16.67%) transcription factor AGA1 YMR306C-A TF YAP5 (2 / 81 16.67%) involved in transcription activation YJL135W YLR465C TF ABF1 (2 / 251 16.67%) ARS-binding factor YCR001W GPR1 + 0.000208 - 0.496669 YJL135W questionable ORF + 0.000119 - 0.496616 YDR048C questionable ORF + 0.000000 - 0.496542 YOR338W similarity to YAL034c + 0.000209 - 0.493447 YMR306C-A questionable ORF + 0.000000 - 0.069882 YOL085C hypothetical protein + 0.000249 - 0.056629 GPR1 G-protein coupled receptor + 0.000000 - 0.038894 YCR001W weak similarity to chloride channel proteins + 0.035194 - 0.000078 ??? ??? + 0.000000 - 0.031799 FIG1 [368 369 703] required for efficient mating + 0.000303 - 0.026532 AGA1 [368 369 703] a-agglutinin anchor subunit + 0.000000 - 0.023486 DAN1 [368 369 703] only expressed under anaerobic conditions + 0.000233 - 0.022182 YLR465C questionable ORF Cluster 5: 19 genes GO term [142]: amino acid metabolism 1.24e-004 categ GO cluster 6 18 microarray 92 1908 GO term [134]: amino acid and derivative metabolism 1.58e-004 categ GO cluster 6 18 microarray 96 1908 GO term [129]: amine metabolism 2.10e-004 categ GO cluster 6 18 microarray 101 1908 GO term [826]: glycine dehydrogenase (decarboxylating) activity 2.51e-004 categ GO cluster 2 18 microarray 3 1908 GO term [1508]: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 2.51e-004 categ GO cluster 2 18 microarray 3 1908 GO term [315]: carboxylic acid metabolism 5.19e-004 categ GO cluster 6 18 microarray 119 1908 GO term [1454]: organic acid metabolism 5.19e-004 categ GO cluster 6 18 microarray 119 1908 GO term [2198]: sulfur amino acid metabolism 5.27e-004 categ GO cluster 3 18 microarray 18 1908 TF REB1 (3 / 128 15.79%) transcription factor TEF4 CSR1 GCV2 TF BAS1 (3 / 37 15.79%) transcription factor GCV1 SNZ3 GCV2 TF NRG1 (2 / 68 10.53%) transcriptional repressor for glucose repression of STA1 gene expression SNZ3 YIR014W TF IME4 (2 / 33 10.53%) positive transcription factor for IME2 SNZ3 YLR346C TF ABF1 (2 / 251 10.53%) ARS-binding factor MAE1 NCE103 TF MET4 (2 / 28 10.53%) transcriptional activator of sulfur metabolism MET28 MET14 + 0.000000 - 0.827346 FIG1 required for efficient mating + 0.000000 - 0.508677 SEO1 suppressor of sulfoxyde ethionine resistance + 0.000000 - 0.121160 YIR014W hypothetical protein + 0.111260 - 0.000000 HSP12 heat shock protein + 0.038012 - 0.000000 BRN1 functional homologue of human BRRN1 + 0.037702 - 0.000000 GCV1 [129 134 142 315 826 1454 1508] "glycine decarboxylase, subunit T" + 0.000000 - 0.030179 MET14 [129 134 142 315 1454 2198] ATP adenosine-5'-phosphosulfate 3'-phosphotransferase + 0.000000 - 0.027870 MET3 [129 134 142 315 1454 2198] sulfate adenylyltransferase + 0.000000 - 0.020630 MET28 [129 134 142 315 1454 2198] transcriptional activator of sulfur amino acid metabolism + 0.019798 - 0.000000 NCE103 involved in non-classical protein export pathway + 0.000000 - 0.019779 ARG1 [129 134 142 315 1454] argininosuccinate synthetase + 0.000000 - 0.018518 RPS22B ribosomal protein S15a.e.c12 + 0.018511 - 0.000551 GCV2 [826 1508] glycine decarboxylase P subunit + 0.000000 - 0.017614 MAE1 [129 134 142 315 1454] malic enzyme + 0.000000 - 0.017590 YOL160W hypothetical protein + 0.000000 - 0.016954 CSR1 weak similarity to SEC14 protein + 0.001119 - 0.016593 YLR346C weak similarity to YGR035c + 0.000000 - 0.015947 TEF4 "translation elongation factor eEF1, gamma chain" + 0.000749 - 0.015909 SNZ3 strong similarity to Para rubber tree ethylene-responsive protein1 Cluster 6: 38 genes GO term [343]: cell adhesion 2.98e-004 categ GO cluster 3 35 microarray 8 1908 GO term [1621]: plasma membrane 4.10e-004 categ GO cluster 8 35 microarray 104 1908 TF NRG1 (8 / 68 21.05%) transcriptional repressor for glucose repression of STA1 gene expression YDL246C YDR042C YFR017C MGA1 YHR156C YIR014W FLO10 TPO4 TF YAP6 (8 / 75 21.05%) "transcription factor, of a fungal-specific family of bzip proteins" YDL246C YDR042C MGA1 YIR014W MUC1 FLO10 ATR1 YOR179C TF PHD1 (5 / 74 13.16%) transcription factor YCR064C MGA1 FLO10 ATR1 RGS2 TF SKN7 (5 / 83 13.16%) transcription factor with similarity to Hsf1p YFR017C MGA1 MUC1 FKS3 TPO4 TF ABF1 (5 / 251 13.16%) ARS-binding factor UBR2 SLA1 GPR1 IDP2 NCE103 TF CIN5 (4 / 129 10.53%) transcriptional activator ECM13 YDR042C MGA1 ATR1 TF SWI4 (4 / 116 10.53%) transcription factor YCR064C YFR017C TSL1 FKS3 TF MBP1 (3 / 99 7.89%) "transcription factor, subunit of the MBF factor" YCR064C YFR017C TSL1 TF SWI5 (3 / 84 7.89%) transcription factor GPR1 YFR017C TSL1 TF ACE2 (3 / 64 7.89%) metallothionein expression activator YFR017C YJR149W TSL1 TF CUP9 (3 / 16 7.89%) involved in copper homeostasis repression of protein import ECM13 YDL246C YDR042C TF MCM1 (2 / 73 5.26%) transcription factor of the MADS box family YDR042C MCM6 TF MET31 (2 / 28 5.26%) transcriptional regulator of sulfur amino acid metabolism YDR042C YHR156C TF GCN4 (2 / 72 5.26%) transcriptional activator of amino acid biosynthetic genes PCL5 ODC2 TF STE12 (2 / 40 5.26%) transcriptional activator SST2 PRM1 TF HIR1 (2 / 27 5.26%) histone transcription regulator TPO4 VTC3 TF SMP1 (2 / 55 5.26%) MADS-box transcription factor YIR014W FLO10 TF BAS1 (2 / 37 5.26%) transcription factor GCV1 VTC3 TF NDD1 (2 / 82 5.26%) protein required for nuclear division YFR017C TSL1 TF ROX1 (2 / 23 5.26%) heme-dependent transcriptional repressor of hypoxic genes YDL246C YDR042C + 0.000484 - 0.905523 MCM6 involved in replication + 0.000000 - 0.317093 MGA1 similarity to heat shock transcription factors + 0.131393 - 0.000000 SST2 [1621] involved in desensitization to alpha-factor pheromone + 0.085979 - 0.000000 HSP12 [343 1621] heat shock protein + 0.081406 - 0.000185 YGL088W questionable ORF + 0.055432 - 0.000342 YHR156C weak similarity to mouse kinesin KIF3B + 0.053318 - 0.000308 SLA1 cytoskeleton assembly control protein + 0.000130 - 0.052620 YDL246C strong similarity to Sor1p + 0.048318 - 0.000400 SIP4 interacts with SNF1 protein kinase + 0.029093 - 0.000345 MUC1 [343 1621] "extracellular alpha-1,4-glucan glucosidase" + 0.028429 - 0.000147 YJR149W similarity to 2-nitropropane dioxygenase + 0.026369 - 0.000573 YIR014W hypothetical protein + 0.024321 - 0.000353 RGS2 negative regulator of glucose-induced cAMP signaling pathway + 0.023320 - 0.000000 PRM1 similarity to S. pombe coiled-coil protein of unknown function + 0.022931 - 0.000218 YLR063W hypothetical protein + 0.022745 - 0.000000 GCV1 "glycine decarboxylase, subunit T" + 0.022299 - 0.000258 IDP2 "isocitrate dehydrogenase, cytosolic" + 0.000121 - 0.022195 HSP30 [1621] heat shock protein + 0.022113 - 0.000989 YDR042C hypothetical protein + 0.000001 - 0.022043 VTC3 "strong similarity to YFL004w, similarity to YJL012c" + 0.020181 - 0.000331 ECM13 involved in cell wall structure of biosynthesis + 0.019407 - 0.000352 FKS3 "similarity to 1,3-beta-glucan synthases" + 0.000000 - 0.018678 YNL144C similarity to YHR131c + 0.000037 - 0.018534 YFR017C hypothetical protein + 0.018470 - 0.000416 YCR064C questionable ORF + 0.018268 - 0.000462 NCE103 involved in non-classical protein export pathway + 0.017659 - 0.000537 GPR1 [1621] G-protein coupled receptor + 0.017604 - 0.000649 FLO10 [343] similarity to Flo1p + 0.017175 - 0.000359 UBR2 similarity to ubiquitin--protein ligase Ubr1p + 0.017117 - 0.000864 ATR1 [1621] aminotriazole and 4-nitroquinoline resistance protein + 0.017000 - 0.000834 PCL5 cyclin like protein interacting with Pho85p + 0.016989 - 0.000341 YOR179C similarity to BRR5 protein + 0.016803 - 0.000184 NRD1 involved in regulation of nuclear pre-mRNA abundance + 0.016624 - 0.000220 CSR2 similarity to YBL101c + 0.016228 - 0.000285 ODC2 similarity to ADP/ATP carrier proteins + 0.000413 - 0.015996 TPO4 [1621] polyamine transporter + 0.015922 - 0.001102 TSL1 "alpha,alpha-trehalose-phosphate synthase, 123 KD subunit" + 0.015613 - 0.000000 ZRT1 [1621] high-affinity zinc transport protein Cluster 8: 18 genes GO term [2190]: sulfate assimilation 8.50e-004 categ GO cluster 2 15 microarray 6 1908 GO term [2202]: sulfur utilization 8.50e-004 categ GO cluster 2 15 microarray 6 1908 TF CIN5 (4 / 129 22.22%) transcriptional activator YRO2 YHL041W ATR1 YML131W TF SWI4 (3 / 116 16.67%) transcription factor CWP1 YLR255C TSL1 TF MBP1 (2 / 99 11.11%) "transcription factor, subunit of the MBF factor" RPS22B TSL1 TF PHD1 (2 / 74 11.11%) transcription factor ATR1 YML131W TF CBF1 (2 / 38 11.11%) kinetochore protein YBR224W MET3 TF RLM1 (2 / 32 11.11%) transcription factor of the MADS box family YHL041W CWP1 TF SWI5 (2 / 84 11.11%) transcription factor TSL1 YML131W TF YAP1 (2 / 40 11.11%) transcriptional activator involved in oxidative stress response YLR460C ATR1 TF BAS1 (2 / 37 11.11%) transcription factor GCV1 VTC3 TF NDD1 (2 / 82 11.11%) protein required for nuclear division RPS22B TSL1 + 0.000000 - 0.733276 SEO1 suppressor of sulfoxyde ethionine resistance + 0.000000 - 0.651502 YBL044W hypothetical protein + 0.000000 - 0.084257 ZRT1 high-affinity zinc transport protein + 0.059611 - 0.000000 YHL041W weak similarity to Drosophila hypothetical protein 6 + 0.000000 - 0.045886 YBR224W questionable ORF + 0.000000 - 0.045554 YGR273C similarity to hypothetical protein YMR295c + 0.027442 - 0.000000 ATR1 aminotriazole and 4-nitroquinoline resistance protein + 0.000000 - 0.025747 MET14 [2190 2202] ATP adenosine-5'-phosphosulfate 3'-phosphotransferase + 0.000000 - 0.025573 CWP1 cell wall mannoprotein + 0.000000 - 0.020670 RPS22B ribosomal protein S15a.e.c12 + 0.000000 - 0.020613 TSL1 "alpha,alpha-trehalose-phosphate synthase, 123 KD subunit" + 0.000000 - 0.019869 MET3 [2190 2202] sulfate adenylyltransferase + 0.018843 - 0.000000 YML131W similarity to human leukotriene b4 12-hydroxydehydrogenase + 0.000000 - 0.018620 YRO2 strong similarity to HSP30 heat shock protein Yro1p + 0.018105 - 0.000000 GCV1 "glycine decarboxylase, subunit T" + 0.016232 - 0.000000 YLR460C similarity to C.carbonum toxD protein + 0.000000 - 0.015985 VTC3 "strong similarity to YFL004w, similarity to YJL012c" + 0.000000 - 0.015817 YLR255C hypothetical protein Cluster 10: 9 genes GO term [876]: heat shock protein activity 8.73e-004 categ GO cluster 2 9 microarray 10 1908 TF GCN4 (2 / 72 22.22%) transcriptional activator of amino acid biosynthetic genes HIS4 ARG1 + 0.945547 - 0.000000 YAL064W hypothetical protein + 0.274073 - 0.000000 HSP12 [876] heat shock protein + 0.139138 - 0.000000 RPL7B 60S large subunit ribosomal protein + 0.000000 - 0.022921 ARG1 argininosuccinate synthetase + 0.000000 - 0.020381 IES6 similarity to SPAC222.04c hypothetical protein S. pombe + 0.017835 - 0.000000 HSP42 [876] heat shock protein + 0.000000 - 0.017751 HIS4 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase + 0.016224 - 0.000000 RGS2 negative regulator of glucose-induced cAMP signaling pathway + 0.015744 - 0.000000 INH1 inhibitor of mitochondrial ATPase Cluster 12: 16 genes GO term [1622]: plasma membrane fusion 9.86e-007 categ GO cluster 3 13 microarray 4 1908 GO term [1957]: response to pheromone 5.37e-005 categ GO cluster 4 13 microarray 34 1908 GO term [510]: cytogamy 1.28e-004 categ GO cluster 2 13 microarray 3 1908 GO term [467]: conjugation 1.81e-004 categ GO cluster 4 13 microarray 46 1908 GO term [468]: conjugation with cellular fusion 1.81e-004 categ GO cluster 4 13 microarray 46 1908 GO term [2078]: sexual reproduction 1.81e-004 categ GO cluster 4 13 microarray 46 1908 GO term [1949]: response to external stimulus 2.85e-004 categ GO cluster 5 13 microarray 97 1908 GO term [1942]: response to chemical substance 3.16e-004 categ GO cluster 4 13 microarray 53 1908 GO term [1958]: response to pheromone during conjugation with cellular fusion 4.05e-004 categ GO cluster 3 13 microarray 23 1908 GO term [380]: cellular morphogenesis during conjugation with cellular fusion 4.24e-004 categ GO cluster 2 13 microarray 5 1908 GO term [1145]: membrane fusion 5.87e-004 categ GO cluster 3 13 microarray 26 1908 GO term [543]: development 6.15e-004 categ GO cluster 6 13 microarray 179 1908 GO term [379]: cellular morphogenesis during conjugation 6.33e-004 categ GO cluster 2 13 microarray 6 1908 TF STE12 (4 / 40 25.00%) transcriptional activator SST2 FIG2 ??? PRM1 TF PDR1 (2 / 53 12.50%) transcription factor YBL113C FIG1 TF MCM1 (2 / 73 12.50%) transcription factor of the MADS box family YDR042C AGA1 TF GCN4 (2 / 72 12.50%) transcriptional activator of amino acid biosynthetic genes TRL1 RIM9 TF SUM1 (2 / 48 12.50%) suppressor of SIR mutations YDR042C YJR078W TF HAP4 (2 / 57 12.50%) CCAAT-binding factor subunit YJR078W YML089C TF ARG81 (2 / 21 12.50%) transcription factor involved in arginine metabolism YDR042C FYV11 + 0.387341 - 0.000397 YDR042C hypothetical protein + 0.000250 - 0.387334 FYV11 [543] similarity to repeat structures in a Plasmodium falciparum protein (MESA) that binds human erythrocyte protein 4.1. + 0.387259 - 0.000000 YML089C questionable ORF + 0.000000 - 0.387192 TRL1 [1949] tRNA ligase + 0.000253 - 0.387183 YBL113C similarity to Y' ORFs + 0.362685 - 0.000100 YLR364W weak similarity to GRX2 Homo sapiens glutaredoxin 2 + 0.000000 - 0.260378 SST2 [467 468 543 1942 1949 1957 2078] involved in desensitization to alpha-factor pheromone + 0.184047 - 0.000000 YDR010C hypothetical protein + 0.095170 - 0.000000 FIG1 [379 380 467 468 510 543 1145 1622 1942 1949 1957 1958 2078] required for efficient mating + 0.029844 - 0.000205 PRM1 [1145 1622] similarity to S. pombe coiled-coil protein of unknown function + 0.027743 - 0.000087 ??? ??? + 0.024649 - 0.000000 BOP2 hypothetical protein + 0.022399 - 0.000071 FIG2 [379 380 467 468 510 543 1145 1622 1942 1949 1957 1958 2078] required for efficient mating + 0.020613 - 0.000587 AGA1 [467 468 543 1942 1949 1957 1958 2078] a-agglutinin anchor subunit + 0.020535 - 0.000121 RIM9 [543] regulator for sporulation and invasive growth + 0.015630 - 0.000000 YJR078W "similarity to mammalian indoleamine 2,3-dioxygenase" Cluster 13: 14 genes GO term [388]: cellular_component unknown 6.16e-004 categ GO cluster 6 11 microarray 220 1908 TF CBF1 (2 / 38 14.29%) kinetochore protein YLL056C IDP2 TF NRG1 (2 / 68 14.29%) transcriptional repressor for glucose repression of STA1 gene expression STL1 YLR012C TF ABF1 (2 / 251 14.29%) ARS-binding factor YIL032C IDP2 + 0.000000 - 0.304051 YLR012C [388] hypothetical protein + 0.304006 - 0.000000 YMR040W strong similarity to Yet1p + 0.000000 - 0.303970 YIL032C hypothetical protein + 0.000116 - 0.303906 SPS18 [388] sporulation-specific zinc-finger protein + 0.303900 - 0.000098 YAL037W [388] strong similarity to GTP-binding proteins + 0.000000 - 0.303883 YLL056C [388] "weak similarity to Y.pseudotuberculosis CDP-3,6-dideoxy-D-glycero-L-glycero-4-hexulose-5-epimerase" + 0.302777 - 0.000237 STL1 member of the sugar permease family + 0.300470 - 0.000127 YKR105C [388] strong similarity to Sge1p and hypothetical protein YCL069w + 0.000000 - 0.298218 DAN1 only expressed under anaerobic conditions + 0.000081 - 0.296141 YMR306C-A questionable ORF + 0.000093 - 0.288705 YBL044W [388] hypothetical protein + 0.039596 - 0.000290 IDP2 "isocitrate dehydrogenase, cytosolic" + 0.026062 - 0.000000 BRN1 functional homologue of human BRRN1 + 0.022693 - 0.000000 SEO1 suppressor of sulfoxyde ethionine resistance Cluster 14: 137 genes GO term [388]: cellular_component unknown 1.30e-012 categ GO cluster 45 131 microarray 220 1908 GO term [254]: biological_process unknown 2.85e-007 categ GO cluster 53 131 microarray 411 1908 GO term [897]: hexose transport 6.22e-007 categ GO cluster 7 131 microarray 10 1908 GO term [1251]: monosaccharide transport 6.22e-007 categ GO cluster 7 131 microarray 10 1908 GO term [750]: fructose transporter activity 6.64e-006 categ GO cluster 6 131 microarray 9 1908 GO term [1117]: mannose transporter activity 6.64e-006 categ GO cluster 6 131 microarray 9 1908 GO term [302]: carbohydrate transport 7.45e-006 categ GO cluster 7 131 microarray 13 1908 GO term [788]: glucose transporter activity 1.57e-005 categ GO cluster 6 131 microarray 10 1908 GO term [898]: hexose transporter activity 1.57e-005 categ GO cluster 6 131 microarray 10 1908 GO term [1252]: monosaccharide transporter activity 1.57e-005 categ GO cluster 6 131 microarray 10 1908 GO term [303]: carbohydrate transporter activity 6.14e-005 categ GO cluster 6 131 microarray 12 1908 GO term [1243]: molecular_function unknown 8.23e-004 categ GO cluster 58 131 microarray 597 1908 TF CIN5 (22 / 129 16.06%) transcriptional activator YAP6 AQY2 FLO9 ECM13 HXT6 YER028C ACA1 YGR035C RNR4 YHL041W YHR049W HXT12 HXT12 YIL172C HXT9 FSP2 YJR011C YML131W ISF1 HXT11 YOR049C YPL062W * TF NRG1 (22 / 68 16.06%) transcriptional repressor for glucose repression of STA1 gene expression NRG1 YAP6 HXT15 HXT13 ACA1 YHL041W YHR156C REC104 HXT12 HXT12 YIL172C YIR014W YJL216C HXT9 FSP2 HXT16 SOR1 FLO10 YLR012C HXT11 YOR049C YPR013C * TF YAP6 (19 / 75 13.87%) "transcription factor, of a fungal-specific family of bzip proteins" YAP6 AQY2 FLO9 HXT15 ACA1 HXT12 HXT12 YIL172C YIR014W MUC1 YJL216C HXT9 FSP2 HXT16 SOR1 FLO10 HXT11 YOR049C YPR013C TF PHD1 (18 / 74 13.14%) transcription factor MSN4 FLO9 RRN10 GIT1 YCR100C HXT15 HXT6 HXT13 ACA1 YJL105W YJL218W HXT9 FSP2 HXT16 SOR1 FLO10 YML131W YPR013C * TF SMP1 (8 / 55 5.84%) MADS-box transcription factor SMP1 YGR283C YIR014W CWP1 FLO10 YKR105C EXG1 CST9 TF SKN7 (7 / 83 5.11%) transcription factor with similarity to Hsf1p NRG1 NRG2 YHL012W MUC1 YJR078W DDR48 YPR009W TF SWI4 (7 / 116 5.11%) transcription factor TOS3 TOS10 YJL185C CWP1 EXG1 SKM1 YPR009W TF MET31 (6 / 28 4.38%) transcriptional regulator of sulfur amino acid metabolism SPS2 YEL072W YHR156C REC104 PEX2 MET16 TF ARO80 (6 / 28 4.38%) positive transcription regulator of ARO9 and ARO10 ARO10 SPS100 YHR140W YHR156C REC104 SPC98 TF FHL1 (6 / 166 4.38%) transcriptional activator of the forkhead/hnf3 family RPS24A UGO1 RTA1 YLR030W TEM1 YOR292C TF SWI6 (5 / 84 3.65%) transcription factor TOS3 YGR110W YJL185C YOL160W SKM1 TF RLM1 (5 / 32 3.65%) transcription factor of the MADS box family HXT15 YHL041W HXT16 CWP1 EXG1 TF DAL81 (5 / 37 3.65%) transcriptional activator for allantoin and GABA catabolic genes BUD3 SEC35 PEX2 YKL118W YLR031W TF SOK2 (5 / 11 3.65%) regulatory protein in the PKA signal transduction pathway YAP6 HXT15 YJL216C HXT16 SOR1 TF MBP1 (4 / 99 2.92%) "transcription factor, subunit of the MBF factor" YGR110W YHL012W EXG1 YNL274C TF PDR1 (4 / 53 2.92%) transcription factor RPS24A FIG1 UGO1 HSH49 TF YJL206C (4 / 20 2.92%) similarity to YIL130p and Put3p YNR071C YPL277C YPL278C YPR013C TF REB1 (4 / 128 2.92%) transcription factor MF(ALPHA)2 YGR243W TUF1 HSH49 TF SUM1 (4 / 48 2.92%) suppressor of SIR mutations DTR1 DIT2 SPS2 YJR078W TF MET4 (4 / 28 2.92%) transcriptional activator of sulfur metabolism YAP5 YFR035C PEX2 CRR1 TF CUP9 (4 / 16 2.92%) involved in copper homeostasis repression of protein import YAP6 ECM13 HXT16 SOR1 TF ROX1 (4 / 23 2.92%) heme-dependent transcriptional repressor of hypoxic genes YAP6 HXT15 HXT16 SOR1 TF IXR1 (3 / 33 2.19%) intrastrand crosslink recognition protein and transcription factor PET130 YKR075C SDH2 TF RFX1 (3 / 28 2.19%) repressor of DNA damage-inducible genes RNR4 RNR3 YMR279C TF MCM1 (3 / 73 2.19%) transcription factor of the MADS box family YMR253C YPL277C YPL278C TF GCN4 (3 / 72 2.19%) transcriptional activator of amino acid biosynthetic genes NPR2 RIM9 KAR5 TF RCS1 (3 / 27 2.19%) iron-regulated transcriptional repressor FIG1 YDR541C YHL012W TF HAP4 (3 / 57 2.19%) CCAAT-binding factor subunit YBL044W YJR078W RPM2 TF ABF1 (3 / 251 2.19%) ARS-binding factor MRP20 LAS21 EBP2 TF BAS1 (3 / 37 2.19%) transcription factor CEM1 JEN1 IDP3 TF FKH2 (3 / 92 2.19%) homology to D.melanogaster forkhead protein YHL023C EXG1 TEM1 TF MAC1 (2 / 30 1.46%) metal binding activator CRR1 DBF20 TF PHO4 (2 / 54 1.46%) transcription factor DAN1 YOL160W TF CBF1 (2 / 38 1.46%) kinetochore protein YLL055W YLL056C TF HAL9 (2 / 16 1.46%) transcriptional activator of ENA1 MSN4 PHM7 TF AZF1 (2 / 7 1.46%) asparagine-rich zinc finger protein NPR2 YHL041W TF GAL4 (2 / 31 1.46%) transcription factor GAL3 HSH49 TF SWI5 (2 / 84 1.46%) transcription factor YLR012C YML131W TF HSF1 (2 / 48 1.46%) heat shock transcription factor TDH3 TAD2 * TF MSN4 (2 / 22 1.46%) transcriptional activator YIL176C YML131W * TF LEU3 (2 / 20 1.46%) transcription factor SPS2 YKL118W TF MOT3 (2 / 17 1.46%) high-copy suppressor of MOT1-SPT3 synthetic lethality SPS2 SOR1 + 0.098724 - 0.000105 MRP20 "ribosomal protein of the large subunit, mitochondrial" + 0.000000 - 0.098706 EBP2 [1243] required for pre-rRNA processing and ribosomal subunit assembly + 0.000026 - 0.098660 SEC35 required for ER to golgi vesicle docking + 0.000000 - 0.098641 REC104 [1243] meiosis-specific protein + 0.098627 - 0.000000 YLR428C questionable ORF + 0.000000 - 0.098619 LEU3 transcription factor + 0.098618 - 0.000000 CST9 "protein required for synapsis, meiotic recombination, sporulation, proper chromosome segregation, and synaptonemal complex formation" + 0.098614 - 0.000000 YHR156C [254] weak similarity to mouse kinesin KIF3B + 0.098611 - 0.000000 SPH1 required for bipolar bud site selection + 0.098609 - 0.000000 TFB4 component of RNA polymerase transcription initiation TFIIH factor + 0.000000 - 0.098603 MSS18 [1243] splicing protein + 0.000000 - 0.098595 ORC1 "origin recognition complex, 104 KD subunit" + 0.000000 - 0.098594 NPR2 [388] nitrogen permease regulator + 0.098589 - 0.000000 YAE1 [254 1243] similarity to S. pombe SPAC2C4.12c putative phosphotransferase + 0.098580 - 0.000000 RIM9 [388 1243] regulator for sporulation and invasive growth + 0.098575 - 0.000000 YGR283C [254 1243] similarity to hypothetical protein YMR310c + 0.000022 - 0.098560 SPS2 [1243] sporulation-specific protein + 0.098543 - 0.000029 BUD3 [1243] budding protein + 0.000107 - 0.098517 PEX2 peroxisomal assembly protein - peroxin + 0.098507 - 0.000000 CRR1 [254 388 1243] similarity to Crh1p cell wall protein + 0.000000 - 0.098500 TUF1 "translation elongation factor TU, mitochondrial" + 0.098496 - 0.000000 MET16 3'-phosphoadenylylsulfate reductase + 0.000051 - 0.098495 YEL072W [254 388 1243] hypothetical protein + 0.098485 - 0.000000 YHL023C [254 388 1243] weak similarity to TRCDSEMBL:SPBC543_4 hypothetical protein S.pombe + 0.000160 - 0.098484 LAS21 required for addition of a side chain to the glycosylphospatidylinositol (GPI) core structure + 0.000000 - 0.098482 KAR5 [1243] nuclear fusion protein + 0.098479 - 0.000000 TAD2 tRNA-specific adenosine deaminase 2 + 0.000016 - 0.098443 DTR1 dityrosine transporter + 0.000000 - 0.098428 YGR110W [254 388 1243] weak similarity to YLR099c and YDR125c + 0.098399 - 0.000000 YJR078W "similarity to mammalian indoleamine 2,3-dioxygenase" + 0.000000 - 0.098399 ARO10 "similarity to Pdc6p, Thi3p and to pyruvate decarboxylases" + 0.000000 - 0.098396 HSH49 essential yeast splicing factor + 0.000002 - 0.098380 YKL118W questionable ORF + 0.000000 - 0.098369 YLR030W [254 388 1243] hypothetical protein + 0.000000 - 0.098368 RRN10 RNA polymerase I-specific transcription initiation factor + 0.000000 - 0.098354 YJL185C [254 388 1243] hypothetical protein + 0.098354 - 0.000000 YFR035C [254 388 1243] hypothetical protein + 0.000000 - 0.098353 YHL012W [254 388 1243] similarity to UDP Glucose pyrophosphorylase + 0.098349 - 0.000000 PUT1 proline oxidase + 0.098346 - 0.000000 YCR100C [254 388 1243] "strong similarity to Pep1p, VTH1p and VTH22p" + 0.098328 - 0.000000 PET130 [254 388 1243] "protein synthesis protein, mitochondrial" + 0.098309 - 0.000000 YDR541C [254 388] similarity to dihydroflavonol-4-reductases + 0.000000 - 0.098303 YAP5 involved in transcription activation + 0.098272 - 0.000000 YNR068C [254 388 1243] similarity to Bul1p + 0.098261 - 0.000000 CEM1 "beta-keto-acyl-ACP synthase, mitochondrial" + 0.098247 - 0.000000 SKM1 [388] Ste20/PAK-like protein kinase + 0.098216 - 0.000000 YGR035C [254 388 1243] hypothetical protein + 0.000000 - 0.098202 MF(ALPHA)2 mating pheromone alpha-2 factor + 0.000000 - 0.098199 YJR011C [254 388 1243] hypothetical protein + 0.000000 - 0.098164 YPL062W hypothetical protein + 0.000000 - 0.098102 YOR292C [254 1243] similarity to human and mouse glomerulosclerosis protein Mpv17 + 0.000000 - 0.098100 UGO1 similarity to chromosome segregation protein Cse1p + 0.098020 - 0.000000 TOS10 [254 388 1243] hypothetical protein + 0.098011 - 0.000067 GAL3 galactokinase + 0.098000 - 0.000000 FIG1 [1243] required for efficient mating + 0.097988 - 0.000000 UBP11 [254 388] ubiquitin C-terminal hydrolase + 0.097968 - 0.000000 YIR014W [254 1243] hypothetical protein + 0.097958 - 0.000000 SDH2 succinate dehydrogenase iron-sulfur protein subunit + 0.097767 - 0.000000 AQY2 strong similarity to AQY1 + 0.097742 - 0.000000 YOL160W hypothetical protein + 0.097733 - 0.000000 YJL105W [254 388 1243] similarity to hypothetical protein YKR029c + 0.097623 - 0.000000 YHR140W [254 1243] hypothetical protein + 0.097540 - 0.000000 EXG1 "exo-beta-1,3-glucanase (I/II), major isoform" + 0.097516 - 0.000000 YPR009W similarity to sterol uptake protein Sut1p + 0.097509 - 0.000000 USV1 [254 388 1243] "similarity to Rgm1p, weak similarity to transcription factors" + 0.097110 - 0.000000 YNL274C similarity to glycerate- and formate-dehydrogenases + 0.096873 - 0.000000 GIT1 glycerophosphoinositol transporter + 0.096709 - 0.000000 ACA1 ATF/CREB activator + 0.096573 - 0.000000 SPO73 [388 1243] hypothetical protein + 0.096543 - 0.000000 SMP1 MADS-box transcription factor + 0.096345 - 0.000000 RTA1 [254 1243] involved in 7-aminocholesterol resistance + 0.096265 - 0.000000 YHL041W weak similarity to Drosophila hypothetical protein 6 + 0.000000 - 0.096192 TEM1 GTP-binding protein of the RAS superfamily + 0.096162 - 0.000000 SOR1 [388] sorbitol dehydrogenase + 0.096012 - 0.000026 YLR031W [254 388 1243] similarity to hypothetical protein YMR124w + 0.000000 - 0.095380 YBL044W [254 388 1243] hypothetical protein + 0.094717 - 0.000000 MSN4 transcriptional activator + 0.094299 - 0.000000 NRG1 transcriptional repressor for glucose repression of STA1 gene expression + 0.094254 - 0.000000 ECM13 [388 1243] involved in cell wall structure of biosynthesis + 0.094079 - 0.000000 RNR3 "ribonucleotide reductase, repair inducible large subunit" + 0.093614 - 0.000000 YIR041W [254 388 1243] similarity to members of the Srp1p/Tip1p family + 0.093596 - 0.000000 RNR4 ribonucleotide reductase small subunit + 0.093302 - 0.000000 YAP6 "transcription factor, of a fungal-specific family of bzip proteins" + 0.092764 - 0.000000 PHM7 [254 1243] similarity to A.thaliana hyp1 protein + 0.092716 - 0.000000 ISF1 [388 1243] involved in suppression of mitochondrial splicing defect + 0.091438 - 0.000000 YGR243W strong similarity to hypothetical protein YHR162w + 0.091204 - 0.000000 FLO9 strong similarity to Flo1p + 0.090373 - 0.000000 YLR012C [254 388 1243] hypothetical protein + 0.089866 - 0.000000 YMR325W [254 388 1243] strong similarity to members of the Srp1p/Tip1p family + 0.087721 - 0.000005 DIT2 [388] cytochrome P450 56 + 0.087398 - 0.000000 YJL216C [254 388] strong similarity to Mal62p + 0.087161 - 0.000000 DAN1 [1243] only expressed under anaerobic conditions + 0.085364 - 0.000000 YKR105C [254 388 1243] strong similarity to Sge1p and hypothetical protein YCL069w + 0.084370 - 0.000000 YMR253C [254 1243] strong similarity to YPL264c + 0.084121 - 0.000000 FSP2 [254 388] strong similarity to alpha-D-glucosidase + 0.083186 - 0.000000 MUC1 [1243] "extracellular alpha-1,4-glucan glucosidase" + 0.082715 - 0.000000 YLL055W [254] similarity to Dal5p + 0.080990 - 0.000000 YIL172C [254] identical to Fsp2p and similarity to other alpha-glucosidases + 0.080551 - 0.000000 HXT15 [302 303 750 788 897 898 1117 1251 1252] strong similarity to Hxt17p and Hxt7p + 0.076688 - 0.000000 MTH1 [302 388 897 1243 1251] repressor of hexose transport genes + 0.074078 - 0.000000 HSP12 heat shock protein + 0.072030 - 0.000000 HXT13 [302 303 750 788 897 898 1117 1251 1252] high-affinity hexose transporter + 0.070775 - 0.000000 YML131W [254 1243] similarity to human leukotriene b4 12-hydroxydehydrogenase + 0.070040 - 0.000000 YNR071C [254 388 1243] strong similarity to UDP-glucose 4-epimerase Gal10p + 0.065948 - 0.000000 SPS100 [1243] sporulation-specific wall maturation protein + 0.065311 - 0.000034 IDP3 "isocitrate dehydrogenase, NADP-dependent" + 0.059441 - 0.000000 HXT16 [302 303 750 788 897 898 1117 1251 1252] member of the hexose transporter family of the major facilitator superfamily [MFS] + 0.055540 - 0.000000 YJL218W [254 388] strong similarity to E.coli galactoside O-acetyltransferase + 0.055155 - 0.000000 TDH3 glyceraldehyde-3-phosphate dehydrogenase 3 + 0.054089 - 0.000000 YPR013C [254 388 1243] similarity to transcription factors + 0.054078 - 0.000000 HXT11 [302 303 750 788 897 898 1117 1251 1252] low affinity glucose transport protein + 0.000000 - 0.052254 RPS24A 40s small subunit ribosomal protein S24.e + 0.048443 - 0.000000 YPL277C [254 1243] strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.048227 - 0.000000 HXT9 [302 303 750 788 897 898 1117 1251 1252] hexose transport protein + 0.047678 - 0.000000 FLO10 similarity to Flo1p + 0.047403 - 0.000000 DDR48 heat shock protein + 0.045866 - 0.000000 YHR049W [254] similarity to S.pombe dihydrofolate reductase and YOR280c + 0.036694 - 0.000000 NRG2 weak similarity to A.niger carbon catabolite repressor protein + 0.035866 - 0.000000 PRM7 [1243] hypothetical protein + 0.034697 - 0.000000 RPM2 "ribonuclease P precursor, mitochondrial" + 0.033342 - 0.000000 YKR075C [254 1243] weak similarity to negative regulator Reg1p + 0.032264 - 0.000000 YPL278C [254 388 1243] strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.000000 - 0.027967 DBF20 cell cycle protein kinase related to Dbf2p + 0.027683 - 0.000000 HXT12 [254 388 1243] strong similarity to sugar transport proteins + 0.026488 - 0.000000 YOR338W [254 388 1243] similarity to YAL034c + 0.024646 - 0.000000 HXT6 [302 303 750 788 897 898 1117 1251 1252] high-affinity hexose transporter + 0.023565 - 0.000000 YLL056C [254 388 1243] "weak similarity to Y.pseudotuberculosis CDP-3,6-dideoxy-D-glycero-L-glycero-4-hexulose-5-epimerase" + 0.023537 - 0.000000 YIL176C [254 388 1243] strong similarity to members of the Srp1p/Tip1p family + 0.000000 - 0.022053 SPC98 spindle pole body component + 0.021611 - 0.000008 JEN1 carboxylic acid transporter protein + 0.020626 - 0.000000 YER028C similarity to Mig1p + 0.019799 - 0.000000 YOR049C "similarity to YER185w, Rta1p" + 0.019629 - 0.000000 TOS3 [254] "strong similarity to Pak1p, Elm1p and Kin82p" + 0.019325 - 0.000001 YMR279C [254 388 1243] strong similarity to aminotriazole resistance protein + 0.018007 - 0.000000 HXT12 [254 388 1243] strong similarity to sugar transport proteins + 0.016918 - 0.000000 CWP1 cell wall mannoprotein + 0.016342 - 0.000000 YGL157W [254] similarity to V.vinifera dihydroflavonol 4-reductase Cluster 23: 17 genes GO term [172]: arginine biosynthesis 3.21e-005 categ GO cluster 3 15 microarray 9 1908 GO term [175]: arginine metabolism 1.07e-004 categ GO cluster 3 15 microarray 13 1908 GO term [2372]: urea cycle intermediate metabolism 1.07e-004 categ GO cluster 3 15 microarray 13 1908 GO term [803]: glutamine family amino acid biosynthesis 4.14e-004 categ GO cluster 3 15 microarray 20 1908 GO term [142]: amino acid metabolism 4.78e-004 categ GO cluster 5 15 microarray 92 1908 GO term [1343]: nitrogen metabolism 5.54e-004 categ GO cluster 3 15 microarray 22 1908 GO term [134]: amino acid and derivative metabolism 5.84e-004 categ GO cluster 5 15 microarray 96 1908 GO term [129]: amine metabolism 7.40e-004 categ GO cluster 5 15 microarray 101 1908 GO term [805]: glutamine family amino acid metabolism 8.16e-004 categ GO cluster 3 15 microarray 25 1908 GO term [1054]: ligase activity, forming carbon-nitrogen bonds 8.16e-004 categ GO cluster 3 15 microarray 25 1908 GO term [136]: amino acid biosynthesis 8.73e-004 categ GO cluster 4 15 microarray 59 1908 TF GCN4 (7 / 72 41.18%) transcriptional activator of amino acid biosynthetic genes HIS4 YHM1 ARG4 PCL5 CPA2 YJR111C ARG1 TF YAP1 (3 / 40 17.65%) transcriptional activator involved in oxidative stress response CPA2 ATR1 YOL119C TF CAD1 (2 / 33 11.76%) transcriptional activator ATR1 YOL119C TF PHO4 (2 / 54 11.76%) transcription factor YGR273C BOP2 TF SWI5 (2 / 84 11.76%) transcription factor YJL160C YLR012C + 0.703136 - 0.000000 YGR273C similarity to hypothetical protein YMR295c + 0.697538 - 0.000000 YLR012C hypothetical protein + 0.057438 - 0.000000 CDC23 [1054] subunit of anaphase-promoting complex (cyclosome) + 0.031312 - 0.000000 SIP4 interacts with SNF1 protein kinase + 0.028048 - 0.000000 CPA2 [129 134 136 142 172 175 803 805 1054 1343 2372] "arginine-specific carbamoylphosphate synthase, large chain" + 0.020837 - 0.000000 ARG4 [129 134 136 142 172 175 803 805 1343 2372] arginosuccinate lyase + 0.019761 - 0.000000 YHM1 member of the mitochondrial carrier family (MCF) + 0.019431 - 0.000000 MET16 [129 134 142] 3'-phosphoadenylylsulfate reductase + 0.019390 - 0.000000 ATR1 aminotriazole and 4-nitroquinoline resistance protein + 0.019216 - 0.000000 YOL119C similarity to monocarboxylate transporter proteins + 0.017775 - 0.000000 PCL5 cyclin like protein interacting with Pho85p + 0.017707 - 0.000053 BOP2 hypothetical protein + 0.000000 - 0.016787 YCR001W weak similarity to chloride channel proteins + 0.015946 - 0.000000 ARG1 [129 134 136 142 172 175 803 805 1054 1343 2372] argininosuccinate synthetase + 0.015811 - 0.000000 HIS4 [129 134 136 142] phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase + 0.015730 - 0.000164 YJL160C strong similarity to Pir1p/Hsp150p/Pir3p family + 0.015717 - 0.000000 YJR111C weak similarity to E.coli colanic acid biosynthesis positive regulator RcsB Cluster 24: 7 genes GO term [2386]: vacuole fusion, non-autophagic 1.72e-004 categ GO cluster 2 6 microarray 7 1908 + 0.926356 - 0.000000 YNL028W questionable ORF + 0.000069 - 0.367338 YCL047C similarity to hypothetical protein SPAC694.03 S. pombe + 0.030534 - 0.000486 VTC3 [2386] "strong similarity to YFL004w, similarity to YJL012c" + 0.026107 - 0.000000 DAN1 only expressed under anaerobic conditions + 0.000000 - 0.019475 UBP11 ubiquitin C-terminal hydrolase + 0.016470 - 0.000861 VTC1 [2386] Negative Regulator of Cdc Fourty two (Cdc42) + 0.016029 - 0.000000 YIL176C strong similarity to members of the Srp1p/Tip1p family Cluster 25: 9 genes GO term [467]: conjugation 7.66e-007 categ GO cluster 5 9 microarray 46 1908 GO term [468]: conjugation with cellular fusion 7.66e-007 categ GO cluster 5 9 microarray 46 1908 GO term [2078]: sexual reproduction 7.66e-007 categ GO cluster 5 9 microarray 46 1908 GO term [1931]: reproduction 8.00e-006 categ GO cluster 5 9 microarray 73 1908 GO term [1957]: response to pheromone 9.96e-006 categ GO cluster 4 9 microarray 34 1908 GO term [543]: development 4.16e-005 categ GO cluster 6 9 microarray 179 1908 GO term [2081]: shmoo tip 5.72e-005 categ GO cluster 3 9 microarray 18 1908 GO term [1942]: response to chemical substance 6.04e-005 categ GO cluster 4 9 microarray 53 1908 GO term [1958]: response to pheromone during conjugation with cellular fusion 1.23e-004 categ GO cluster 3 9 microarray 23 1908 GO term [346]: cell communication 1.93e-004 categ GO cluster 4 9 microarray 71 1908 GO term [1938]: response to abiotic stimulus 3.39e-004 categ GO cluster 4 9 microarray 82 1908 GO term [1949]: response to external stimulus 6.50e-004 categ GO cluster 4 9 microarray 97 1908 GO term [1621]: plasma membrane 8.50e-004 categ GO cluster 4 9 microarray 104 1908 TF STE12 (4 / 40 44.44%) transcriptional activator SST2 TEC1 FUS1 GPA1 TF MCM1 (2 / 73 22.22%) transcription factor of the MADS box family STE6 AGA1 + 0.992633 - 0.000000 RPS26A 40S small subunit ribosomal protein S26e.c7 + 0.000283 - 0.043989 AGA1 [346 467 468 543 1931 1938 1942 1949 1957 1958 2078] a-agglutinin anchor subunit + 0.002185 - 0.043883 FUS1 [467 468 543 1621 1931 2078 2081] cell fusion protein + 0.000006 - 0.033324 SST2 [346 467 468 543 1621 1931 1938 1942 1949 1957 2078] involved in desensitization to alpha-factor pheromone + 0.000004 - 0.024052 STE6 [1621 2081] ATP-binding cassette transporter protein + 0.000021 - 0.020450 GPA1 [346 467 468 543 1621 1931 1938 1942 1949 1957 1958 2078] GTP-binding protein alpha subunit of the pheromone pathway + 0.000003 - 0.020313 TEC1 [543] Ty transcription activator + 0.000032 - 0.019788 FUS3 [346 467 468 543 1931 1938 1942 1949 1957 1958 2078 2081] mitogen-activated protein kinase (MAP kinase) + 0.018316 - 0.000078 YDR031W weak similarity to squalene synthase; Artemisia annua Cluster 27: 141 genes GO term [388]: cellular_component unknown 0.00e+000 categ GO cluster 46 134 microarray 220 1908 GO term [254]: biological_process unknown 9.12e-008 categ GO cluster 55 134 microarray 411 1908 GO term [897]: hexose transport 7.28e-007 categ GO cluster 7 134 microarray 10 1908 GO term [1251]: monosaccharide transport 7.28e-007 categ GO cluster 7 134 microarray 10 1908 GO term [750]: fructose transporter activity 7.59e-006 categ GO cluster 6 134 microarray 9 1908 GO term [1117]: mannose transporter activity 7.59e-006 categ GO cluster 6 134 microarray 9 1908 GO term [302]: carbohydrate transport 8.69e-006 categ GO cluster 7 134 microarray 13 1908 GO term [788]: glucose transporter activity 1.79e-005 categ GO cluster 6 134 microarray 10 1908 GO term [898]: hexose transporter activity 1.79e-005 categ GO cluster 6 134 microarray 10 1908 GO term [1252]: monosaccharide transporter activity 1.79e-005 categ GO cluster 6 134 microarray 10 1908 GO term [303]: carbohydrate transporter activity 6.99e-005 categ GO cluster 6 134 microarray 12 1908 GO term [1243]: molecular_function unknown 4.63e-004 categ GO cluster 60 134 microarray 597 1908 TF CIN5 (24 / 129 17.02%) transcriptional activator YAP6 AQY2 FLO9 ECM13 HXT6 YER028C ACA1 YGR035C RNR4 YHL041W YHR049W HXT12 HXT12 YIL172C HXT9 FSP2 YJR011C YML131W ISF1 GRE2 HXT11 YOL157C YOR049C YPL062W * TF NRG1 (23 / 68 16.31%) transcriptional repressor for glucose repression of STA1 gene expression NRG1 YAP6 HXT15 HXT13 ACA1 YHL041W YHR156C REC104 HXT12 HXT12 YIL172C YIR014W YJL216C HXT9 FSP2 HXT16 SOR1 FLO10 YLR012C HXT11 YOL157C YOR049C YPR013C * TF YAP6 (21 / 75 14.89%) "transcription factor, of a fungal-specific family of bzip proteins" YAP6 AQY2 FLO9 HXT15 ACA1 HXT12 HXT12 YIL172C YIR014W MUC1 YJL216C YJL217W HXT9 FSP2 HXT16 SOR1 FLO10 HXT11 YOL157C YOR049C YPR013C TF PHD1 (19 / 74 13.48%) transcription factor MSN4 FLO9 RRN10 GIT1 YCR100C HXT15 HXT6 HXT13 ACA1 YJL105W YJL217W YJL218W HXT9 FSP2 HXT16 SOR1 FLO10 YML131W YPR013C TF SKN7 (8 / 83 5.67%) transcription factor with similarity to Hsf1p NRG1 NRG2 YHL012W MUC1 YJR078W YKR040C DDR48 YPR009W TF SWI4 (8 / 116 5.67%) transcription factor TOS3 TOS10 YJL185C CWP1 YKR040C EXG1 SKM1 YPR009W * TF SMP1 (8 / 55 5.67%) MADS-box transcription factor SMP1 YGR283C YIR014W CWP1 FLO10 YKR105C EXG1 CST9 TF MET31 (6 / 28 4.26%) transcriptional regulator of sulfur amino acid metabolism SPS2 YEL072W YHR156C REC104 PEX2 MET16 TF ARO80 (6 / 28 4.26%) positive transcription regulator of ARO9 and ARO10 ARO10 SPS100 YHR140W YHR156C REC104 SPC98 TF DAL81 (6 / 37 4.26%) transcriptional activator for allantoin and GABA catabolic genes BUD3 SEC35 PEX2 YKL118W YKR040C YLR031W TF FHL1 (6 / 166 4.26%) transcriptional activator of the forkhead/hnf3 family RPS24A UGO1 RTA1 YLR030W TEM1 YOR292C TF SWI6 (5 / 84 3.55%) transcription factor TOS3 YGR110W YJL185C YOL160W SKM1 TF RLM1 (5 / 32 3.55%) transcription factor of the MADS box family HXT15 YHL041W HXT16 CWP1 EXG1 TF SOK2 (5 / 11 3.55%) regulatory protein in the PKA signal transduction pathway YAP6 HXT15 YJL216C HXT16 SOR1 TF MBP1 (4 / 99 2.84%) "transcription factor, subunit of the MBF factor" YGR110W YHL012W EXG1 YNL274C TF PDR1 (4 / 53 2.84%) transcription factor RPS24A FIG1 UGO1 HSH49 TF YJL206C (4 / 20 2.84%) similarity to YIL130p and Put3p YNR071C YPL277C YPL278C YPR013C TF MCM1 (4 / 73 2.84%) transcription factor of the MADS box family YKR040C YMR253C YPL277C YPL278C TF REB1 (4 / 128 2.84%) transcription factor MF(ALPHA)2 YGR243W TUF1 HSH49 TF SUM1 (4 / 48 2.84%) suppressor of SIR mutations DTR1 DIT2 SPS2 YJR078W TF FKH2 (4 / 92 2.84%) homology to D.melanogaster forkhead protein YHL023C YKR040C EXG1 TEM1 TF MET4 (4 / 28 2.84%) transcriptional activator of sulfur metabolism YAP5 YFR035C PEX2 CRR1 TF CUP9 (4 / 16 2.84%) involved in copper homeostasis repression of protein import YAP6 ECM13 HXT16 SOR1 TF ROX1 (4 / 23 2.84%) heme-dependent transcriptional repressor of hypoxic genes YAP6 HXT15 HXT16 SOR1 TF MAC1 (3 / 30 2.13%) metal binding activator YJL217W CRR1 DBF20 TF IXR1 (3 / 33 2.13%) intrastrand crosslink recognition protein and transcription factor PET130 YKR075C SDH2 TF RFX1 (3 / 28 2.13%) repressor of DNA damage-inducible genes RNR4 RNR3 YMR279C TF GCN4 (3 / 72 2.13%) transcriptional activator of amino acid biosynthetic genes NPR2 RIM9 KAR5 TF RCS1 (3 / 27 2.13%) iron-regulated transcriptional repressor FIG1 YDR541C YHL012W TF HAP4 (3 / 57 2.13%) CCAAT-binding factor subunit YBL044W YJR078W RPM2 TF ABF1 (3 / 251 2.13%) ARS-binding factor MRP20 LAS21 EBP2 TF BAS1 (3 / 37 2.13%) transcription factor CEM1 JEN1 IDP3 TF PHO4 (2 / 54 1.42%) transcription factor DAN1 YOL160W TF CBF1 (2 / 38 1.42%) kinetochore protein YLL055W YLL056C TF HAL9 (2 / 16 1.42%) transcriptional activator of ENA1 MSN4 PHM7 TF AZF1 (2 / 7 1.42%) asparagine-rich zinc finger protein NPR2 YHL041W TF GAL4 (2 / 31 1.42%) transcription factor GAL3 HSH49 TF SWI5 (2 / 84 1.42%) transcription factor YLR012C YML131W TF HSF1 (2 / 48 1.42%) heat shock transcription factor TDH3 TAD2 * TF MSN4 (2 / 22 1.42%) transcriptional activator YIL176C YML131W * TF LEU3 (2 / 20 1.42%) transcription factor SPS2 YKL118W TF MOT3 (2 / 17 1.42%) high-copy suppressor of MOT1-SPT3 synthetic lethality SPS2 SOR1 + 0.000687 - 0.098904 YJR011C [254 388 1243] hypothetical protein + 0.098889 - 0.000712 YGR035C [254 388 1243] hypothetical protein + 0.000760 - 0.098846 YPL062W hypothetical protein + 0.098734 - 0.001095 YIR014W [254 1243] hypothetical protein + 0.000939 - 0.098726 REC104 [1243] meiosis-specific protein + 0.098696 - 0.001027 AQY2 strong similarity to AQY1 + 0.098666 - 0.000938 YHR156C [254] weak similarity to mouse kinesin KIF3B + 0.000274 - 0.098578 YHL012W [254 388 1243] similarity to UDP Glucose pyrophosphorylase + 0.000392 - 0.098427 YJL185C [254 388 1243] hypothetical protein + 0.098403 - 0.000457 YJR078W "similarity to mammalian indoleamine 2,3-dioxygenase" + 0.098395 - 0.000354 SKM1 [388] Ste20/PAK-like protein kinase + 0.000386 - 0.098364 HSH49 essential yeast splicing factor + 0.098338 - 0.001500 ACA1 ATF/CREB activator + 0.000000 - 0.098328 YGR110W [254 388 1243] weak similarity to YLR099c and YDR125c + 0.098283 - 0.000846 EXG1 "exo-beta-1,3-glucanase (I/II), major isoform" + 0.000000 - 0.098283 YLR030W [254 388 1243] hypothetical protein + 0.000375 - 0.098225 UGO1 similarity to chromosome segregation protein Cse1p + 0.000607 - 0.098214 RRN10 RNA polymerase I-specific transcription initiation factor + 0.098182 - 0.000606 YCR100C [254 388 1243] "strong similarity to Pep1p, VTH1p and VTH22p" + 0.098056 - 0.000208 CST9 "protein required for synapsis, meiotic recombination, sporulation, proper chromosome segregation, and synaptonemal complex formation" + 0.098036 - 0.000143 YHL023C [254 388 1243] weak similarity to TRCDSEMBL:SPBC543_4 hypothetical protein S.pombe + 0.000273 - 0.098034 YOR292C [254 1243] similarity to human and mouse glomerulosclerosis protein Mpv17 + 0.000312 - 0.098028 SPS2 [1243] sporulation-specific protein + 0.098018 - 0.000292 YGR283C [254 1243] similarity to hypothetical protein YMR310c + 0.000179 - 0.097968 TUF1 "translation elongation factor TU, mitochondrial" + 0.000164 - 0.097948 SEC35 required for ER to golgi vesicle docking + 0.000429 - 0.097931 PEX2 peroxisomal assembly protein - peroxin + 0.097929 - 0.000286 TOS10 [254 388 1243] hypothetical protein + 0.000162 - 0.097929 NPR2 [388] nitrogen permease regulator + 0.000074 - 0.097926 KAR5 [1243] nuclear fusion protein + 0.097901 - 0.000000 TAD2 tRNA-specific adenosine deaminase 2 + 0.097897 - 0.000115 CRR1 [254 388 1243] similarity to Crh1p cell wall protein + 0.097868 - 0.000144 RIM9 [388 1243] regulator for sporulation and invasive growth + 0.097846 - 0.000178 BUD3 [1243] budding protein + 0.097823 - 0.000525 YPR009W similarity to sterol uptake protein Sut1p + 0.097819 - 0.000000 MRP20 "ribosomal protein of the large subunit, mitochondrial" + 0.000000 - 0.097818 EBP2 [1243] required for pre-rRNA processing and ribosomal subunit assembly + 0.000000 - 0.097795 ORC1 "origin recognition complex, 104 KD subunit" + 0.000000 - 0.097790 MSS18 [1243] splicing protein + 0.000000 - 0.097774 LEU3 transcription factor + 0.097767 - 0.000000 TFB4 component of RNA polymerase transcription initiation TFIIH factor + 0.097763 - 0.000000 SPH1 required for bipolar bud site selection + 0.097759 - 0.000000 YLR428C questionable ORF + 0.000167 - 0.097751 YEL072W [254 388 1243] hypothetical protein + 0.097729 - 0.000000 YAE1 [254 1243] similarity to S. pombe SPAC2C4.12c putative phosphotransferase + 0.097675 - 0.000108 PET130 [254 388 1243] "protein synthesis protein, mitochondrial" + 0.000143 - 0.097644 MF(ALPHA)2 mating pheromone alpha-2 factor + 0.000118 - 0.097644 YKL118W questionable ORF + 0.000083 - 0.097634 DTR1 dityrosine transporter + 0.000000 - 0.097624 ARO10 "similarity to Pdc6p, Thi3p and to pyruvate decarboxylases" + 0.097587 - 0.000606 YJL105W [254 388 1243] similarity to hypothetical protein YKR029c + 0.097557 - 0.000151 YFR035C [254 388 1243] hypothetical protein + 0.097511 - 0.000131 MET16 3'-phosphoadenylylsulfate reductase + 0.000000 - 0.097506 LAS21 required for addition of a side chain to the glycosylphospatidylinositol (GPI) core structure + 0.097503 - 0.000000 YDR541C [254 388] similarity to dihydroflavonol-4-reductases + 0.097502 - 0.000000 PUT1 proline oxidase + 0.000005 - 0.097462 YAP5 involved in transcription activation + 0.097461 - 0.000000 CEM1 "beta-keto-acyl-ACP synthase, mitochondrial" + 0.097443 - 0.000000 FIG1 [1243] required for efficient mating + 0.097417 - 0.001263 YHL041W weak similarity to Drosophila hypothetical protein 6 + 0.097394 - 0.000028 YNR068C [254 388 1243] similarity to Bul1p + 0.097385 - 0.000215 YOL160W hypothetical protein + 0.097305 - 0.000000 GAL3 galactokinase + 0.097216 - 0.000077 SDH2 succinate dehydrogenase iron-sulfur protein subunit + 0.097146 - 0.000000 UBP11 [254 388] ubiquitin C-terminal hydrolase + 0.097131 - 0.001242 SOR1 [388] sorbitol dehydrogenase + 0.096875 - 0.000000 YHR140W [254 1243] hypothetical protein + 0.000421 - 0.096863 TEM1 GTP-binding protein of the RAS superfamily + 0.096832 - 0.000187 YNL274C similarity to glycerate- and formate-dehydrogenases + 0.096718 - 0.000586 GIT1 glycerophosphoinositol transporter + 0.096648 - 0.000000 USV1 [254 388 1243] "similarity to Rgm1p, weak similarity to transcription factors" + 0.096246 - 0.000276 RTA1 [254 1243] involved in 7-aminocholesterol resistance + 0.096040 - 0.000276 SMP1 MADS-box transcription factor + 0.095734 - 0.000000 SPO73 [388 1243] hypothetical protein + 0.095137 - 0.000187 YLR031W [254 388 1243] similarity to hypothetical protein YMR124w + 0.094940 - 0.000779 ECM13 [388 1243] involved in cell wall structure of biosynthesis + 0.094713 - 0.001302 YAP6 "transcription factor, of a fungal-specific family of bzip proteins" + 0.094649 - 0.000937 NRG1 transcriptional repressor for glucose repression of STA1 gene expression + 0.094534 - 0.000666 MSN4 transcriptional activator + 0.094373 - 0.000817 RNR4 ribonucleotide reductase small subunit + 0.000000 - 0.094155 YBL044W [254 388 1243] hypothetical protein + 0.093247 - 0.000740 ISF1 [388 1243] involved in suppression of mitochondrial splicing defect + 0.093209 - 0.000076 RNR3 "ribonucleotide reductase, repair inducible large subunit" + 0.092819 - 0.000000 YIR041W [254 388 1243] similarity to members of the Srp1p/Tip1p family + 0.092599 - 0.001314 FLO9 strong similarity to Flo1p + 0.091871 - 0.000062 PHM7 [254 1243] similarity to A.thaliana hyp1 protein + 0.091049 - 0.000130 YGR243W strong similarity to hypothetical protein YHR162w + 0.090498 - 0.000000 YLR012C [254 388 1243] hypothetical protein + 0.089059 - 0.000000 YMR325W [254 388 1243] strong similarity to members of the Srp1p/Tip1p family + 0.087983 - 0.000854 YJL216C [254 388] strong similarity to Mal62p + 0.086955 - 0.000150 DIT2 [388] cytochrome P450 56 + 0.086443 - 0.000000 DAN1 [1243] only expressed under anaerobic conditions + 0.085905 - 0.001485 FSP2 [254 388] strong similarity to alpha-D-glucosidase + 0.084747 - 0.000283 YKR105C [254 388 1243] strong similarity to Sge1p and hypothetical protein YCL069w + 0.083933 - 0.000083 YMR253C [254 1243] strong similarity to YPL264c + 0.083912 - 0.000880 MUC1 [1243] "extracellular alpha-1,4-glucan glucosidase" + 0.082440 - 0.001223 YIL172C [254] identical to Fsp2p and similarity to other alpha-glucosidases + 0.082006 - 0.000000 YLL055W [254] similarity to Dal5p + 0.081774 - 0.001228 HXT15 [302 303 750 788 897 898 1117 1251 1252] strong similarity to Hxt17p and Hxt7p + 0.076102 - 0.000000 MTH1 [302 388 897 1243 1251] repressor of hexose transport genes + 0.072759 - 0.001039 HXT13 [302 303 750 788 897 898 1117 1251 1252] high-affinity hexose transporter + 0.072573 - 0.001285 YML131W [254 1243] similarity to human leukotriene b4 12-hydroxydehydrogenase + 0.071365 - 0.000000 HSP12 heat shock protein + 0.070089 - 0.000029 YNR071C [254 388 1243] strong similarity to UDP-glucose 4-epimerase Gal10p + 0.065584 - 0.000182 SPS100 [1243] sporulation-specific wall maturation protein + 0.064828 - 0.000015 IDP3 "isocitrate dehydrogenase, NADP-dependent" + 0.060813 - 0.001265 HXT16 [302 303 750 788 897 898 1117 1251 1252] member of the hexose transporter family of the major facilitator superfamily [MFS] + 0.055793 - 0.001233 HXT11 [302 303 750 788 897 898 1117 1251 1252] low affinity glucose transport protein + 0.055779 - 0.000609 YJL218W [254 388] strong similarity to E.coli galactoside O-acetyltransferase + 0.055434 - 0.001242 YPR013C [254 388 1243] similarity to transcription factors + 0.054983 - 0.000000 TDH3 glyceraldehyde-3-phosphate dehydrogenase 3 + 0.000386 - 0.052808 RPS24A 40s small subunit ribosomal protein S24.e + 0.050344 - 0.001511 HXT9 [302 303 750 788 897 898 1117 1251 1252] hexose transport protein + 0.049228 - 0.001406 FLO10 similarity to Flo1p + 0.048368 - 0.000105 YPL277C [254 1243] strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.047520 - 0.000131 DDR48 heat shock protein + 0.047044 - 0.000751 YHR049W [254] similarity to S.pombe dihydrofolate reductase and YOR280c + 0.036878 - 0.000251 NRG2 weak similarity to A.niger carbon catabolite repressor protein + 0.035690 - 0.000000 PRM7 [1243] hypothetical protein + 0.034547 - 0.000091 RPM2 "ribonuclease P precursor, mitochondrial" + 0.033281 - 0.000030 YKR075C [254 1243] weak similarity to negative regulator Reg1p + 0.032353 - 0.000112 YPL278C [254 388 1243] strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.029699 - 0.001237 HXT12 [254 388 1243] strong similarity to sugar transport proteins + 0.000000 - 0.027854 DBF20 cell cycle protein kinase related to Dbf2p + 0.026411 - 0.001169 HXT6 [302 303 750 788 897 898 1117 1251 1252] high-affinity hexose transporter + 0.026090 - 0.000000 YOR338W [254 388 1243] similarity to YAL034c + 0.025760 - 0.001219 YOL157C [254 388 1243] strong similarity to alpha-glucosidases + 0.023472 - 0.000000 YLL056C [254 388 1243] "weak similarity to Y.pseudotuberculosis CDP-3,6-dideoxy-D-glycero-L-glycero-4-hexulose-5-epimerase" + 0.023404 - 0.000032 YIL176C [254 388 1243] strong similarity to members of the Srp1p/Tip1p family + 0.022142 - 0.000728 YER028C similarity to Mig1p + 0.000122 - 0.022023 SPC98 spindle pole body component + 0.021736 - 0.001259 YOR049C "similarity to YER185w, Rta1p" + 0.021523 - 0.000031 JEN1 carboxylic acid transporter protein + 0.020436 - 0.000359 TOS3 [254] "strong similarity to Pak1p, Elm1p and Kin82p" + 0.020066 - 0.001244 HXT12 [254 388 1243] strong similarity to sugar transport proteins + 0.019265 - 0.000088 YMR279C [254 388 1243] strong similarity to aminotriazole resistance protein + 0.018612 - 0.000000 CWP1 cell wall mannoprotein + 0.016408 - 0.001021 YJL217W [254 1243] similarity to conserved hypothetical protein VCA0345 Vibrio cholerae + 0.016367 - 0.000000 YGL157W [254] similarity to V.vinifera dihydroflavonol 4-reductase + 0.016293 - 0.000914 YKR040C questionable ORF + 0.016211 - 0.000755 GRE2 similarity to plant dihydroflavonol-4-reductases Cluster 32: 10 genes GO term [467]: conjugation 1.12e-008 categ GO cluster 6 9 microarray 46 1908 GO term [468]: conjugation with cellular fusion 1.12e-008 categ GO cluster 6 9 microarray 46 1908 GO term [2078]: sexual reproduction 1.12e-008 categ GO cluster 6 9 microarray 46 1908 GO term [1957]: response to pheromone 1.59e-007 categ GO cluster 5 9 microarray 34 1908 GO term [1931]: reproduction 1.96e-007 categ GO cluster 6 9 microarray 73 1908 GO term [2081]: shmoo tip 6.80e-007 categ GO cluster 4 9 microarray 18 1908 GO term [1942]: response to chemical substance 1.58e-006 categ GO cluster 5 9 microarray 53 1908 GO term [543]: development 1.75e-006 categ GO cluster 7 9 microarray 179 1908 GO term [1958]: response to pheromone during conjugation with cellular fusion 1.95e-006 categ GO cluster 4 9 microarray 23 1908 GO term [346]: cell communication 6.96e-006 categ GO cluster 5 9 microarray 71 1908 GO term [1938]: response to abiotic stimulus 1.43e-005 categ GO cluster 5 9 microarray 82 1908 GO term [2093]: signal transduction during conjugation with cellular fusion 1.57e-005 categ GO cluster 3 9 microarray 12 1908 GO term [859]: G-protein coupled receptor protein signaling pathway 3.21e-005 categ GO cluster 3 9 microarray 15 1908 GO term [1949]: response to external stimulus 3.29e-005 categ GO cluster 5 9 microarray 97 1908 GO term [1963]: response to stimulus 3.30e-005 categ GO cluster 6 9 microarray 172 1908 GO term [1621]: plasma membrane 4.63e-005 categ GO cluster 5 9 microarray 104 1908 GO term [367]: cell surface receptor linked signal transduction 5.72e-005 categ GO cluster 3 9 microarray 18 1908 GO term [2101]: site of polarized growth 7.53e-005 categ GO cluster 4 9 microarray 56 1908 GO term [2102]: site of polarized growth (sensu Fungi) 7.53e-005 categ GO cluster 4 9 microarray 56 1908 GO term [2103]: site of polarized growth (sensu Saccharomyces) 7.53e-005 categ GO cluster 4 9 microarray 56 1908 GO term [2092]: signal transduction 8.66e-005 categ GO cluster 4 9 microarray 58 1908 GO term [1862]: receptor signaling protein activity 2.94e-004 categ GO cluster 2 9 microarray 6 1908 TF STE12 (4 / 40 40.00%) transcriptional activator SST2 TEC1 FUS1 GPA1 TF MCM1 (2 / 73 20.00%) transcription factor of the MADS box family STE6 AGA1 TF SWI4 (2 / 116 20.00%) transcription factor YGR050C AGA1 + 0.946743 - 0.000492 YGR050C questionable ORF + 0.000199 - 0.300805 STE5 [346 367 467 468 543 859 1621 1862 1931 1938 1942 1949 1957 1958 1963 2078 2081 2092 2093 2101 2102 2103] pheromone signal transduction pathway protein + 0.000580 - 0.053553 AGA1 [346 467 468 543 1931 1938 1942 1949 1957 1958 1963 2078] a-agglutinin anchor subunit + 0.000000 - 0.028551 TEC1 [543] Ty transcription activator + 0.000000 - 0.026573 SST2 [346 467 468 543 1621 1931 1938 1942 1949 1957 1963 2078 2092] involved in desensitization to alpha-factor pheromone + 0.000000 - 0.025150 FUS1 [467 468 543 1621 1931 2078 2081 2101 2102 2103] cell fusion protein + 0.024050 - 0.000000 RAD18 [1963] DNA repair protein + 0.000000 - 0.018746 FUS3 [346 367 467 468 543 859 1862 1931 1938 1942 1949 1957 1958 1963 2078 2081 2092 2093 2101 2102 2103] mitogen-activated protein kinase (MAP kinase) + 0.000000 - 0.016773 GPA1 [346 367 467 468 543 859 1621 1931 1938 1942 1949 1957 1958 1963 2078 2092 2093] GTP-binding protein alpha subunit of the pheromone pathway + 0.000000 - 0.016190 STE6 [1621 2081 2101 2102 2103] ATP-binding cassette transporter protein Cluster 33: 24 genes GO term [595]: DNA-directed DNA polymerase activity 2.80e-004 categ GO cluster 2 19 microarray 3 1908 TF ABF1 (4 / 251 16.67%) ARS-binding factor TOM6 SEC18 UBP1 RPB10 TF SWI4 (3 / 116 12.50%) transcription factor SOK2 TOS6 TOS11 TF HSF1 (3 / 48 12.50%) heat shock transcription factor YGR198W BUD7 YOR300W TF PDR1 (2 / 53 8.33%) transcription factor YBL112C YDR543C TF SKN7 (2 / 83 8.33%) transcription factor with similarity to Hsf1p SOK2 KNS1 TF RGM1 (2 / 21 8.33%) transcriptional repressor protein YBL112C YDR543C TF GAL4 (2 / 31 8.33%) transcription factor YBL112C YDR543C TF CIN5 (2 / 129 8.33%) transcriptional activator YMR244C-A SMT3 TF SWI5 (2 / 84 8.33%) transcription factor YDR543C YLR346C TF YAP5 (2 / 81 8.33%) involved in transcription activation YBL112C YDR543C TF HAP4 (2 / 57 8.33%) CCAAT-binding factor subunit YDR543C COX12 + 0.000326 - 0.222370 TOS11 hypothetical protein + 0.000000 - 0.222334 SOK2 regulatory protein in the PKA signal transduction pathway + 0.000000 - 0.222261 TOM6 "mitochondrial outer membrane import receptor subunit, 6 kD" + 0.000000 - 0.222259 SEC18 "vesicular-fusion protein, functional homolog of NSF" + 0.000193 - 0.222132 SMT3 ubiquitin-like protein + 0.000000 - 0.222128 YMR244C-A questionable ORF + 0.000000 - 0.222095 KNS1 ser/thr protein kinase + 0.000000 - 0.222064 YLR346C weak similarity to YGR035c + 0.000000 - 0.222046 YBL112C strong similarity to subtelomeric encoded proteins + 0.222029 - 0.000100 YDL068W questionable ORF + 0.000000 - 0.222016 CUP1-2 metallothionein + 0.000000 - 0.222006 TDH2 glyceraldehyde-3-phosphate dehydrogenase 2 + 0.000000 - 0.221976 DPB11 [595] involved in DNA replication and S-phase checkpoint + 0.000309 - 0.213840 RPB10 "DNA-directed polymerase I, II, III 8.3 subunit" + 0.213797 - 0.000242 YGR198W weak similarity to PIR:T38996 hypothetical protein SPAC637.04 S. pombe + 0.213605 - 0.000059 YNL043C questionable ORF + 0.213594 - 0.000311 TOS6 similarity to Mid2p + 0.000230 - 0.212319 YOR300W questionable ORF + 0.205780 - 0.000244 BUD7 involved in bud-site selection + 0.205646 - 0.000094 COX12 "cytochrome-c oxidase, subunit VIB" + 0.205621 - 0.000084 TRF4 [595] topoisomerase I-related protein + 0.000000 - 0.045805 YDR543C strong similarity to subtelomeric encoded proteins + 0.000337 - 0.025493 UBP1 ubiquitin-specific protease + 0.018281 - 0.000000 MLH2 "similarity to human mutL protein homolog, mouse PMS2, Mlh1p and Pms1p" Cluster 40: 482 genes GO term [255]: biosynthesis 2.20e-013 categ GO cluster 144 453 microarray 371 1908 GO term [136]: amino acid biosynthesis 4.14e-013 categ GO cluster 40 453 microarray 59 1908 GO term [127]: amine biosynthesis 1.03e-012 categ GO cluster 42 453 microarray 62 1908 GO term [134]: amino acid and derivative metabolism 3.56e-012 categ GO cluster 54 453 microarray 96 1908 GO term [142]: amino acid metabolism 5.20e-012 categ GO cluster 52 453 microarray 92 1908 GO term [129]: amine metabolism 7.01e-012 categ GO cluster 55 453 microarray 101 1908 GO term [315]: carboxylic acid metabolism 6.88e-010 categ GO cluster 58 453 microarray 119 1908 GO term [1454]: organic acid metabolism 6.88e-010 categ GO cluster 58 453 microarray 119 1908 GO term [368]: cell wall 3.75e-007 categ GO cluster 28 453 microarray 49 1908 GO term [369]: cell wall (sensu Fungi) 3.75e-007 categ GO cluster 28 453 microarray 49 1908 GO term [703]: external encapsulating structure 3.75e-007 categ GO cluster 28 453 microarray 49 1908 GO term [528]: cytosolic ribosome (sensu Eukarya) 4.04e-007 categ GO cluster 52 453 microarray 118 1908 GO term [1479]: oxidoreductase activity 1.24e-006 categ GO cluster 47 453 microarray 106 1908 GO term [172]: arginine biosynthesis 2.26e-006 categ GO cluster 9 453 microarray 9 1908 GO term [2182]: structural constituent of ribosome 5.53e-006 categ GO cluster 54 453 microarray 133 1908 GO term [175]: arginine metabolism 5.94e-006 categ GO cluster 11 453 microarray 13 1908 GO term [2372]: urea cycle intermediate metabolism 5.94e-006 categ GO cluster 11 453 microarray 13 1908 GO term [1098]: macromolecule biosynthesis 2.08e-005 categ GO cluster 100 453 microarray 299 1908 GO term [1002]: ion transporter activity 2.88e-005 categ GO cluster 27 453 microarray 55 1908 GO term [2000]: ribosome 3.28e-005 categ GO cluster 57 453 microarray 150 1908 GO term [205]: aspartate family amino acid metabolism 3.28e-005 categ GO cluster 14 453 microarray 21 1908 GO term [2183]: structural molecule activity 4.14e-005 categ GO cluster 62 453 microarray 168 1908 GO term [529]: cytosolic small ribosomal subunit (sensu Eukarya) 5.93e-005 categ GO cluster 25 453 microarray 51 1908 GO term [690]: eukaryotic 43S preinitiation complex 5.93e-005 categ GO cluster 25 453 microarray 51 1908 GO term [691]: eukaryotic 48S initiation complex 5.93e-005 categ GO cluster 25 453 microarray 51 1908 GO term [671]: ergosterol biosynthesis 6.86e-005 categ GO cluster 8 453 microarray 9 1908 GO term [672]: ergosterol metabolism 6.86e-005 categ GO cluster 8 453 microarray 9 1908 GO term [526]: cytosol 7.17e-005 categ GO cluster 71 453 microarray 202 1908 GO term [331]: cation transporter activity 7.98e-005 categ GO cluster 23 453 microarray 46 1908 GO term [1351]: nonprotein amino acid metabolism 1.75e-004 categ GO cluster 6 453 microarray 6 1908 GO term [2190]: sulfate assimilation 1.75e-004 categ GO cluster 6 453 microarray 6 1908 GO term [2202]: sulfur utilization 1.75e-004 categ GO cluster 6 453 microarray 6 1908 GO term [2201]: sulfur metabolism 1.90e-004 categ GO cluster 15 453 microarray 26 1908 GO term [2173]: sterol biosynthesis 2.45e-004 categ GO cluster 9 453 microarray 12 1908 GO term [1085]: lyase activity 2.68e-004 categ GO cluster 14 453 microarray 24 1908 GO term [527]: cytosolic large ribosomal subunit (sensu Eukarya) 2.71e-004 categ GO cluster 27 453 microarray 61 1908 GO term [2109]: small ribosomal subunit 2.74e-004 categ GO cluster 26 453 microarray 58 1908 GO term [1343]: nitrogen metabolism 3.77e-004 categ GO cluster 13 453 microarray 22 1908 GO term [805]: glutamine family amino acid metabolism 4.79e-004 categ GO cluster 14 453 microarray 25 1908 GO term [803]: glutamine family amino acid biosynthesis 5.28e-004 categ GO cluster 12 453 microarray 20 1908 GO term [1456]: organic acid transporter activity 5.28e-004 categ GO cluster 12 453 microarray 20 1908 GO term [706]: extracellular 6.29e-004 categ GO cluster 9 453 microarray 13 1908 GO term [2170]: steroid biosynthesis 6.29e-004 categ GO cluster 9 453 microarray 13 1908 GO term [2174]: sterol metabolism 6.29e-004 categ GO cluster 9 453 microarray 13 1908 GO term [2198]: sulfur amino acid metabolism 7.35e-004 categ GO cluster 11 453 microarray 18 1908 GO term [955]: hydro-lyase activity 7.42e-004 categ GO cluster 5 453 microarray 5 1908 GO term [1466]: ornithine metabolism 7.42e-004 categ GO cluster 5 453 microarray 5 1908 GO term [267]: branched chain family amino acid metabolism 7.90e-004 categ GO cluster 8 453 microarray 11 1908 GO term [186]: aromatic amino acid family metabolism 9.34e-004 categ GO cluster 7 453 microarray 9 1908 GO term [265]: branched chain family amino acid biosynthesis 9.34e-004 categ GO cluster 7 453 microarray 9 1908 TF FHL1 (58 / 166 12.03%) transcriptional activator of the forkhead/hnf3 family GCN4 RPL12A RPL20A RPS8A RPL23A TPS1 RPL21A RPS29B YDL133W RPL35B RPL35A RPS13 RPL37B RPL23B YER130C RPS26B RPL30 RPL24A RPS2 RPL9A RPS25A RPL26B RPL11B RPS20 RPL16A RPL40A RPS22A RPS5 RPS4A RPL14A RPS27A RPS21A RPS0B RPL22A RPS31 TOS4 RPS28B RPL38 RPP0 RPL26A RPS22B RPS29A RPS1A RPS1B RPL9B RPS3 RPL25 RPS15 RKI1 RPS10A RPL20B RPS12 RPL21B RPS6A RPL5 RPL11A RPS18B RPL6A * TF SWI4 (50 / 116 10.37%) transcription factor SWI4 CLB2 CLB6 ERG3 FKS1 MNN1 RNR1 YBR071W ECM33 HCM1 HO HTA1 GIC2 YHP1 RPL37B GIN4 YER079W YFR017C TOS3 BUD9 TOS10 CRH1 SIM1 CIS3 SWE1 CDC6 ELO1 BAT2 CWP1 LAP4 TOS5 PRY2 PTR2 RAX2 HAP1 MID2 YOX1 TSL1 YMR144W CLN1 SCW10 RPS3 AGA1 PLB3 SRL1 TOS11 YOR315W HHO1 SVS1 YPL267W * TF GCN4 (44 / 72 9.13%) transcriptional activator of amino acid biosynthetic genes UGA3 MET4 ALD5 "ARG5,6" HIS1 YBR043C LYS2 ARO4 HIS4 GLT1 LYS20 YHM1 ARO3 ARO1 YDR341C HOM3 TRP2 ARG4 PCL5 YHR162W ARG2 ARG3 YJL200C BNA1 ??? ??? ??? CPA2 YJR111C ATP7 YLR356W ICY1 LEU4 ARG1 MET22 YOR108W ORT1 MCT1 ODC2 YOR302W CPA1 TEA1 CAR1 ASN1 TF CIN5 (36 / 129 7.47%) transcriptional activator ALD5 ERG28 YMR244C-A ECM13 YRO2 YBR071W AGP1 YCL047C SED1 HXT6 YEL045C ACA1 HXK2 YGR035C KEL2 AAP1' FUR1 RPI1 ICS3 YJL171C RPS4A LAP4 FAS1 GAP1 YPS3 MID2 ATR1 RPS3 GRE2 YOR049C WTM1 YOR302W CPA1 YOR306C YOR315W ALD6 TF MBP1 (34 / 99 7.05%) "transcription factor, subunit of the MBF factor" SWI4 CLB6 VTC1 RNR1 RFA1 SEN34 YBR071W ECM33 HCM1 MCD1 ERP3 YHP1 RPL37B GIN4 HLR1 YER079W YFR017C YGR110W SPO16 ESC4 SWE1 CDC6 ELO1 MRP8 RPS22B YOX1 TSL1 YMR144W CLN1 YMR215W YNR009W AGA1 SRL1 TOS11 TF ABF1 (34 / 251 7.05%) ARS-binding factor RIM101 ERG3 SOD1 YHL029C AUR1 YAL053W PMT2 CDS1 ECM33 NGR1 SSH1 GPR1 QRI2 YDL193W MSS4 LYS4 QCR9 YHR162W YHR199C YIL135C ECM17 ATP7 RPS28B GSP1 YLR400W YMR093W ROT1 NCE103 IDH1 YNL057W MDM20 PTP2 NOP58 YPL159C TF FKH2 (32 / 92 6.64%) homology to D.melanogaster forkhead protein SWI5 ZMS1 CLB2 RNR1 PMA1 YBL032W RIB1 BRN1 CHS2 ECM33 ERP3 YHP1 RPL37B YER079W YER124C YGL114W YHR143W YIL158W YJL051W CIS3 BUD4 CPA2 RAX2 YLR400W RPS1B YMR144W CLN1 YMR215W SRL1 TOS11 YOR315W NCE102 * TF SWI5 (29 / 84 6.02%) transcription factor ASH1 CST13 GPR1 YDL173W DLD1 YDL223C YER079W YFR017C BUD9 YGR086C CRH1 YHB1 YRF1-3 YHR138C FAA3 PRY3 SCP160 HSP150 YJL160C PIR3 YLR049C YLR194C YLR346C TSL1 CHS1 ZWF1 EGT2 YOR264W YPL158C TF NDD1 (28 / 82 5.81%) protein required for nuclear division SWI5 ZMS1 CLB2 YHL029C PMA1 CHS2 ECM33 YHP1 YER079W YFR017C YGL114W YIL158W YJL051W PRY1 CIS3 BUD4 RAX2 RPS22B TSL1 YMR144W CLN1 MFA2 ZWF1 YOR024W SRL1 TOS11 YOR315W NCE102 TF SWI6 (26 / 84 5.39%) transcription factor SWI4 RNR1 ECM33 ERP3 HO MKC7 GIC2 GIN4 HLR1 YER079W TOS3 BUD9 YGR110W SPO16 ESC4 SIM1 SWE1 (MLP1) TOS5 PRY2 MID2 YOX1 CLN1 HHO1 SVS1 YPL267W TF ACE2 (23 / 64 4.77%) metallothionein expression activator YAP1 ERG6 PMA1 CST13 HOM2 YER079W SER3 YER124C YFR017C SCW11 BUD9 YHB1 YHR143W PRY3 SCP160 HSP150 RPS4A YJR149W MCR1 YKL151C TSL1 ZWF1 EGT2 TF MCM1 (22 / 73 4.56%) transcription factor of the MADS box family SWI4 SWI5 CLB2 YHP1 GIN4 HLR1 YEL045C YGL114W SIM1 YIL158W YJL051W YJL160C CDC6 ELO1 BUD4 PIR3 RAX2 MFA2 AGA1 YOR315W PDE2 YPL278C TF SKN7 (21 / 83 4.36%) transcription factor with similarity to Hsf1p YAP1 NRG1 ERG6 STB4 HOM2 GIC2 TIR1 YER079W YFR017C CLB1 YGR210C CIS3 MIR1 BAT2 MRP8 PTR2 CCW12 DDR48 SCW10 MFA2 YOR315W * TF PHD1 (19 / 74 3.94%) transcription factor ZMS1 ERG5 STB4 YHL029C CST13 HCM1 YCR100C GIC2 HXT6 CYC7 ACA1 YHR213W VTH1 YJL217W AYT1 ATR1 ICY1 RPS3 DIP5 TF HSF1 (19 / 48 3.94%) heat shock transcription factor REB1 EFB1 YBL032W RIB1 APA1 RPN4 SNQ2 HOM2 HSP42 BTN2 YGR146C TDH3 SNG1 YGR210C YKL051W GPM1 HSP104 TSL1 YNL134C TF YAP6 (17 / 75 3.53%) "transcription factor, of a fungal-specific family of bzip proteins" SED1 YEL045C ACA1 KEL2 AAP1' RPI1 YJL217W RPS4A YPS3 YLR294C ATR1 RPS3 YNR067C ENB1 YOR049C YOR315W NCE102 * TF REB1 (16 / 128 3.32%) transcription factor CLB2 YMR040W HOM2 YER156C PRP43 YGR243W YIL023C YIL108W RPL40A CIS3 TEF4 SDH1 GCV2 CYB5 YNL115C PSD1 TF HAP4 (16 / 57 3.32%) CCAAT-binding factor subunit RIP1 ATP1 ATP3 HMLALPHA2 IDP1 COX9 INH1 ERG26 COX13 QCR9 YRF1-3 MIR1 ATP7 YLR294C YRF1-6 ATP15 * TF NRG1 (15 / 68 3.11%) transcriptional repressor for glucose repression of STA1 gene expression NRG1 MNN1 SED1 YDR133C YDR134C TIR1 ACA1 YFR017C YHR033W YHR138C RPI1 CYB5 YOR049C YOR315W YPL251W TF YAP5 (15 / 81 3.11%) involved in transcription activation HMLALPHA2 COS4 ERG1 COS6 YRF1-3 COS8 RPL16A BUD19 RPS22A COS5 COS3 COS1 YRF1-6 RPS6A RPL6A TF RLM1 (14 / 32 2.90%) transcription factor of the MADS box family ASE1 FKS1 MNN1 SED1 YPS5 CRH1 CIS3 HSP150 CWP1 SRL3 CCW12 MID2 LYS9 YOR315W * TF BAS1 (14 / 37 2.90%) transcription factor CEM1 GCV3 HIS4 GCV1 ADE8 YGL186C ADE3 SHM2 RPL22A GCV2 YMR191W ZRC1 VTC3 YPL251W TF PHO4 (13 / 54 2.70%) transcription factor GRX1 YER079W ILV1 KRE35 YHR130C OM45 YJL051W YJL200C YLR152C YLR266C BOP2 TEA1 YPL251W TF FKH1 (13 / 57 2.70%) "forkhead protein, involved in transcriptional silencing, cell morphology and cell cycle" CDS1 YCL063W CHA1 ERS1 SUB2 YHR143W YIL158W BUD4 TSL1 YMR184W YMR215W MKK2 ALG5 * TF YAP1 (13 / 40 2.70%) transcriptional activator involved in oxidative stress response ERG28 RPN4 SNQ2 YEL045C YER079W YFL057C YGL114W YHB1 CPA2 DRE2 ATR1 YNL134C YOL119C TF SMP1 (13 / 55 2.70%) MADS-box transcription factor ASH1 MNN1 RPL23A PCA1 TCM10 TIR1 YPS5 BGL2 SLT2 CWP1 YNL115C YRF1-6 SGE1 * TF MET4 (13 / 28 2.70%) transcriptional activator of sulfur metabolism CYS3 RAD59 MET10 ERG25 ADE3 MET28 PRY3 OPT1 MET14 SUL2 YLR179C SAM1 HHF2 TF DAL81 (12 / 37 2.49%) transcriptional activator for allantoin and GABA catabolic genes BAP2 TAT1 AGP1 LYS20 YEL045C OPT1 PTR2 BUD28 YLR112W RNY1 DIP5 ASN1 TF MET31 (11 / 28 2.28%) transcriptional regulator of sulfur amino acid metabolism CYS3 RPL37B STR3 ADE3 YJL060W OPT1 ECM17 YLR179C SAM1 LYS9 MET16 TF CAD1 (10 / 33 2.07%) transcriptional activator YEL045C YGL157W ARN1 LAP4 RSM22 DRE2 ATR1 YNL134C YOL119C YOR173W TF SUM1 (10 / 48 2.07%) suppressor of SIR mutations PMT2 YCL049C DAL1 YJL038C BNA1 ??? ??? ??? MIR1 YLR343W TF LEU3 (10 / 20 2.07%) transcription factor MET4 BAT1 BAP2 LEU1 YHR209W OAC1 ILV2 LEU4 YOR108W YOR271C TF PDR1 (9 / 53 1.87%) transcription factor RPL12A RPL23A YFR017C YRF1-3 RPL16A BUD19 COS3 YRF1-6 YPL251W TF STE12 (9 / 40 1.87%) transcriptional activator FUS1 PYC1 CRH1 SIM1 CWP1 SRL3 CLN1 MFA2 SGE1 TF STB1 (8 / 22 1.66%) Sin3p binding protein FKS1 HCM1 RPL37B CSI2 SRL1 TOS11 BBP1 CLN2 TF PHO2 (8 / 27 1.66%) homeodomain protein CUP5 HIS4 RAD59 TDH3 SIM1 YJL161W YLR152C YNL057W TF CBF1 (7 / 38 1.45%) kinetochore protein REB1 FAT2 ARO4 MET10 ADE3 ARO9 MET3 TF IXR1 (7 / 33 1.45%) intrastrand crosslink recognition protein and transcription factor RPL23A HXT5 RPI1 SDH2 RPS31 YOR024W YOR315W TF INO4 (7 / 15 1.45%) basic helix-loop-helix transcription factor SWI5 SOD1 CDS1 CHO1 CHO2 EPT1 FAS1 TF HIR1 (7 / 27 1.45%) histone transcription regulator HHF1 HTA1 YKL202W RPL22A HHF2 VTC3 YPL251W TF ARG81 (7 / 21 1.45%) transcription factor involved in arginine metabolism "ARG5,6" ARG3 ARG8 ARG1 YOR302W CPA1 DIP5 TF ARG80 (6 / 15 1.24%) transcription factor involved in arginine metabolism "ARG5,6" ARG3 ARG8 YOR302W CPA1 DIP5 TF HIR2 (6 / 19 1.24%) histone transcription regulator ERG28 HHF1 HTA1 YJL160C HHF2 LPE10 TF SFP1 (6 / 26 1.24%) zinc finger protein ENA2 RPL23B YFR017C YGR250C RPS31 ZWF1 TF RGM1 (6 / 21 1.24%) transcriptional repressor protein COS4 COS8 COS5 COS3 COS1 YRF1-6 TF ARO80 (6 / 28 1.24%) positive transcription regulator of ARO9 and ARO10 HMLALPHA2 ARO10 ARO9 YHR138C ESBP6 YPL251W TF IME4 (6 / 33 1.24%) positive transcription factor for IME2 YER083C YFR017C YHR138C YLR346C ZWF1 YPL251W TF HAP2 (5 / 16 1.04%) CCAAT-binding factor subunit GPX2 QCR9 YHB1 ISA1 VTC3 TF IKI1 (5 / 16 1.04%) confers sensitivity to killer toxin GPX2 QCR9 YHB1 ISA1 VTC3 TF GAL4 (5 / 31 1.04%) transcription factor HMLALPHA2 YCR106W COS3 COS1 YRF1-6 TF PUT3 (5 / 8 1.04%) positive activator of the proline utilisation pathway RPL16A YOL155C YOR302W CPA1 YOR306C TF CUP9 (5 / 16 1.04%) involved in copper homeostasis repression of protein import ECM13 SED1 ERG26 RPI1 PTR2 TF ROX1 (5 / 23 1.04%) heme-dependent transcriptional repressor of hypoxic genes SED1 MSS4 RPI1 YOR315W IMD4 * TF GLN3 (4 / 14 0.83%) transcription factor for positive nitrogen regulation GCN4 UGA3 GLT1 ASN1 * TF MAC1 (4 / 30 0.83%) metal binding activator TGL2 MSS4 FTR1 YJL217W TF INO2 (4 / 7 0.83%) basic helix-loop-helix (BHLH) transcription factor SWI5 KEL2 ARG4 FAS1 * TF RFX1 (4 / 28 0.83%) repressor of DNA damage-inducible genes SPO16 ESC4 RNR2 POS5 TF DAL82 (4 / 11 0.83%) transcriptional activator for allantoin catabolic genes PRM7 MET10 DAL1 CAR2 TF HAL9 (4 / 16 0.83%) transcriptional activator of ENA1 MNN1 RPS13 ERG26 YNL134C TF RCS1 (4 / 27 0.83%) iron-regulated transcriptional repressor RPL22A ZWF1 VTC3 YPL251W TF MSN4 (4 / 22 0.83%) transcriptional activator SSA4 YRF1-3 YIL176C HSP104 TF RTG1 (3 / 9 0.62%) basic helix-loop-helix transcription factor that regulates CIT2 gene expression BAS1 BRN1 YJL038C TF YFL044C (3 / 22 0.62%) weak similarity to human dystrophin VAC8 YBR012C HSP30 * TF RME1 (3 / 16 0.62%) zinc-finger transcription factor MKC7 YER079W RPS22B TF GCR2 (3 / 24 0.62%) glycolytic genes transcriptional activator TDH3 TDH2 YPL251W TF ZAP1 (3 / 19 0.62%) metalloregulatory protein involved in zinc-responsive transcriptional regulation ZRT1 YRF1-3 ZRT2 TF HAP3 (2 / 19 0.41%) CCAAT-binding factor subunit ATP3 ISA1 * TF MTH1 (2 / 11 0.41%) repressor of hexose transport genes PRM7 YDL124W TF DOT6 (2 / 9 0.41%) involved in derepression of telomeric silencing RFA1 SEN34 TF FZF1 (2 / 14 0.41%) sulfite resistance protein DFG5 RNY1 TF YJL206C (2 / 20 0.41%) similarity to YIL130p and Put3p YEL045C YPL278C TF GCR1 (2 / 9 0.41%) transcriptional activator CDC19 TDH3 TF ADR1 (2 / 5 0.41%) zinc-finger transcription factor ZWF1 YPL251W TF STP1 (2 / 14 0.41%) "pre-tRNA splicing protein, transcription factor" AGP1 DIP5 TF CRZ1 (2 / 12 0.41%) calcineurin responsive zinc-finger YCR106W TRP3 + 0.004550 - 0.414160 YDL133W hypothetical protein + 0.252738 - 0.018532 HSP12 heat shock protein + 0.231678 - 0.003089 ARO9 [129 134 142 186 315 1454] aromatic amino acid aminotransferase II + 0.007195 - 0.174100 YHR130C weak similarity to T.brucei H+-transporting ATP synthase + 0.159131 - 0.005387 NCE103 involved in non-classical protein export pathway + 0.020605 - 0.135844 ZRT1 [331 1002] high-affinity zinc transport protein + 0.118313 - 0.015876 CPA2 [127 129 134 136 142 172 175 255 315 526 803 805 1343 1454 2372] "arginine-specific carbamoylphosphate synthase, large chain" + 0.006817 - 0.105752 BRN1 functional homologue of human BRRN1 + 0.101177 - 0.015525 BNA1 [255 1098 1479] 3-hydroxyanthranilic acid dioxygenase + 0.095825 - 0.014708 ARG4 [127 129 134 136 142 172 175 255 315 526 803 805 1085 1343 1454 2372] arginosuccinate lyase + 0.094534 - 0.005079 YLR194C [368 369 703] hypothetical protein + 0.092533 - 0.020454 "ARG5,6" [127 129 134 136 142 172 175 255 315 803 805 1343 1351 1454 1466 1479 2372] acetylglutamate kinase and acetylglutamyl-phosphate reductase + 0.084342 - 0.009826 PCL5 cyclin like protein interacting with Pho85p + 0.083116 - 0.000000 YOR338W similarity to YAL034c + 0.043972 - 0.082924 CWP1 [368 369 703 2183] cell wall mannoprotein + 0.078970 - 0.005627 BOP2 hypothetical protein + 0.078967 - 0.022128 HIS4 [127 129 134 136 142 255 315 1454 1479] phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase + 0.078107 - 0.002455 YHR209W similarity to hypothetical protein YER175c + 0.076763 - 0.014712 MET16 [129 134 142 205 315 1454 1479 2190 2198 2201 2202] 3'-phosphoadenylylsulfate reductase + 0.069431 - 0.005574 YOL119C [1002 1456] similarity to monocarboxylate transporter proteins + 0.068466 - 0.008550 ATR1 aminotriazole and 4-nitroquinoline resistance protein + 0.066670 - 0.003223 YPS3 GPI-anchored aspartyl protease 3 (yapsin 3) + 0.004619 - 0.062253 YCL047C similarity to hypothetical protein SPAC694.03 S. pombe + 0.061215 - 0.019596 MET10 [1479 2190 2201 2202] sulfite reductase flavin-binding subunit + 0.060854 - 0.006898 SIP4 [255 1098] interacts with SNF1 protein kinase + 0.059669 - 0.000000 YGR110W weak similarity to YLR099c and YDR125c + 0.059331 - 0.003000 SRL3 similarity to YOR083w + 0.059257 - 0.020225 ARG1 [127 129 134 136 142 172 175 255 315 526 803 805 1343 1351 1454 2372] argininosuccinate synthetase + 0.059053 - 0.004300 GCV1 [129 134 142 315 1454 1479] "glycine decarboxylase, subunit T" + 0.058591 - 0.001712 YLR343W strong similarity to Gas1p and C.albicans pH responsive protein + 0.058374 - 0.013586 YHM1 member of the mitochondrial carrier family (MCF) + 0.058083 - 0.009492 MET22 [127 129 134 136 142 205 255 315 1454 2190 2198 2201 2202] protein ser/thr phosphatase + 0.056602 - 0.002916 YHR138C hypothetical protein + 0.054944 - 0.008261 LEU4 [127 129 134 136 142 255 265 267 315 1454] 2-isopropylmalalate synthase + 0.010570 - 0.053944 CHA1 [129 134 142 205 315 1085 1454] L-serine/L-threonine deaminase + 0.002179 - 0.051818 MNN1 [255 1098] "alpha-1,3-mannosyltransferase" + 0.051488 - 0.002324 YOR306C [1002 1456] similarity to human X-linked PEST-containing transporter + 0.002606 - 0.049470 CLB6 "cyclin, B-type" + 0.049380 - 0.002204 (MLP1) strong similarity to ser/thr-specific protein kinase Slt2p + 0.047829 - 0.009393 LYS20 [127 129 134 136 142 205 255 315 1454] homocitrate synthase + 0.047723 - 0.017576 ERG5 [255 671 672 1098 2170 2173 2174] C-22 sterol desaturase + 0.047589 - 0.008026 ORT1 [127 129 134 136 142 172 175 255 315 803 805 1343 1454 1456 2372] "ornithine transport protein of mitochondria involved in arginine metabolism, member of the mitochondrial carrier family (MCF)" + 0.044069 - 0.047224 ERG3 [255 671 672 1098 1479 2170 2173 2174] C-5 sterol desaturase + 0.003710 - 0.046976 CLB1 "cyclin, G2/M-specific" + 0.046861 - 0.023027 ARG3 [127 129 134 136 142 172 175 255 315 526 803 805 1343 1351 1454 1466 2372] ornithine carbamoyltransferase + 0.046679 - 0.010957 SUL2 [1002] sulfate transporter + 0.045965 - 0.016828 ENB1 [331 1002] a gene of the major facilitator superfamily encodes a transporter for enterobactin + 0.045767 - 0.008071 ILV2 [127 129 134 136 142 255 265 267 315 1454] acetolactate synthase + 0.045743 - 0.003141 GSC2 [255 1098] "1,3-beta-D-glucan synthase subunit" + 0.045124 - 0.010682 ARN1 [331 1002] ferrichrome-type siderophore transporter + 0.044600 - 0.007885 HOM2 [127 129 134 136 142 205 255 315 1454 1479 2198 2201] aspartate-semialdehyde dehydrogenase + 0.044184 - 0.008459 HOM3 [127 129 134 136 142 205 255 315 1454 2198 2201] L-aspartate 4-P-transferase + 0.043654 - 0.000000 STR3 [127 129 134 136 142 205 255 315 1085 1454 2198 2201] strong similarity to Emericella nidulans and similarity to other cystathionine beta-lyase and Cys3p + 0.043317 - 0.007769 YHR162W strong similarity to hypothetical protein YGR243w + 0.002772 - 0.043208 ALD6 [255 315 1454 1479] "aldehyde dehydrogenase, cytosolic" + 0.043111 - 0.004890 ARO4 [127 129 134 136 142 186 255 315 1454] "2-dehydro-3-deoxyphosphoheptonate aldolase, tyrosine-inhibited" + 0.042873 - 0.006103 SER3 [127 129 134 136 142 255 315 1454 1479] 3-phosphoglycerate dehydrogenase + 0.042453 - 0.008170 CPA1 [127 129 134 136 142 172 175 255 315 526 803 805 1343 1454 2372] "arginine-specific carbamoylphosphate synthase, small chain" + 0.042316 - 0.004605 ARO1 [127 129 134 136 142 186 255 315 955 1085 1454 1479] arom pentafunctional enzyme + 0.002331 - 0.041827 YMR215W [368 369 703] similarity to GAS1 protein + 0.041516 - 0.002649 YJL161W hypothetical protein + 0.041304 - 0.011434 SED1 [368 369 703 2000 2183] abundant cell surface glycoprotein + 0.001605 - 0.040986 OPT1 [2201] oligopeptide transporter specific for tetra- and pentapeptides + 0.040877 - 0.007131 ARO3 [127 129 134 136 142 186 255 315 1454] "2-dehydro-3-deoxyphosphoheptonate aldolase, phenylalanine-inhibited" + 0.004821 - 0.040815 CLB2 "cyclin, G2/M-specific" + 0.040731 - 0.001630 SLT2 ser/thr protein kinase of MAP kinase family + 0.040578 - 0.009083 HSP150 [368 369 703 2183] member of the Pir1p/Hsp150p/Pir3p family + 0.039894 - 0.002525 MCR1 [255 671 672 1098 1479 2170 2173 2174] cytochrome-b5 reductase + 0.039804 - 0.004243 TEA1 TY1 enhancer activator + 0.039398 - 0.007698 AGP1 [1456] asparagine and glutamine permease + 0.039329 - 0.007111 ??? ??? + 0.038769 - 0.006380 YJR111C weak similarity to E.coli colanic acid biosynthesis positive regulator RcsB + 0.005302 - 0.038518 TEF4 [255 1098 2000] "translation elongation factor eEF1, gamma chain" + 0.022157 - 0.038444 LEU1 [127 129 134 136 142 255 265 267 315 526 955 1085 1454] 3-isopropylmalate dehydratase + 0.037930 - 0.005667 UGA3 [1343] transcriptional activator for GABA catabolic genes + 0.002352 - 0.037917 ZRT2 [331 1002] low affininty zinc transporter + 0.002714 - 0.037868 TOS4 similarity to YDR501w + 0.037820 - 0.005585 PIR3 [368 369 703 2183] member of the Pir1p/Pir2p/Pir3p family + 0.037701 - 0.008242 IDP1 [127 129 134 136 142 255 315 803 805 1454 1479] "isocitrate dehydrogenase (NADP+), mitochondrial" + 0.037010 - 0.007523 ASN1 [127 129 134 136 142 205 255 315 1454] asparagine synthetase + 0.037000 - 0.015730 TSL1 [255 1098] "alpha,alpha-trehalose-phosphate synthase, 123 KD subunit" + 0.015012 - 0.036936 TOS11 hypothetical protein + 0.036703 - 0.005562 DDR48 heat shock protein + 0.036547 - 0.000000 SEO1 suppressor of sulfoxyde ethionine resistance + 0.000000 - 0.036282 RPI1 [255] negative regulator of ras-cAMP pathway + 0.036240 - 0.002501 YKL151C similarity to C.elegans hypothetical protein R107.2 + 0.002215 - 0.035906 YBL032W weak similarity to hnRNP complex protein homolog YBR233w + 0.035641 - 0.002689 ERG1 [255 671 672 1098 1479 2170 2173 2174] squalene monooxygenase + 0.035637 - 0.014669 ECM17 [127 129 134 136 142 255 315 1454 1479 2190 2201 2202] involved in cell wall biogenesis and architecture + 0.034303 - 0.005629 PYC1 [255 526 1098] pyruvate carboxylase 1 + 0.034053 - 0.010778 ??? ??? + 0.008282 - 0.033909 ECM33 involved in cell wall biogenesis and architecture + 0.033833 - 0.005505 ??? ??? + 0.007595 - 0.033612 RNR1 [1479] "ribonucleoside-diphosphate reductase, large subunit" + 0.013471 - 0.033510 YER124C weak similarity to Dictyostelium WD40 repeat protein 2 + 0.010740 - 0.033461 YHR143W [368 369 703 706] weak similarity to a-agglutinin core protein AGA1 + 0.005769 - 0.033450 YER083C hypothetical protein + 0.033422 - 0.004624 GCV2 [1479] glycine decarboxylase P subunit + 0.033161 - 0.003903 ??? ??? + 0.033073 - 0.010158 CRH1 [368 369 703] family of putative glycosidases might exert a common role in cell wall organization + 0.033018 - 0.010798 ??? ??? + 0.032987 - 0.002801 POS5 [255 1098] similarity to Utr1p and YEL041w + 0.032782 - 0.022171 MET14 [129 134 142 205 315 1454 2190 2198 2201 2202] ATP adenosine-5'-phosphosulfate 3'-phosphotransferase + 0.032613 - 0.002235 GCV3 [1479] "glycine decarboxylase, subunit H" + 0.032374 - 0.008624 BAT2 [127 129 134 136 142 255 265 267 315 1454] "branched chain amino acid aminotransferase, cytosolic" + 0.032216 - 0.004719 YBR043C similarity to benomyl/methotrexate resistance protein + 0.032211 - 0.010886 LYS2 [127 129 134 136 142 205 255 315 1454 1479] "L-aminoadipate-semialdehyde dehydrogenase, large subunit" + 0.002382 - 0.032084 YPL267W weak similarity to C.elegans transcription factor unc-86 + 0.016543 - 0.032055 FTR1 [331 1002] iron permease that mediates high-affinity iron uptake + 0.032001 - 0.009767 IDH1 [127 129 134 136 142 255 315 803 805 1454 1479] "isocitrate dehydrogenase (NAD+) subunit 1, mitochondrial" + 0.031770 - 0.001271 YMR191W hypothetical protein + 0.031701 - 0.004140 YLR152C similarity to YOR3165w and YNL095c + 0.005967 - 0.031581 YHB1 flavohemoglobin + 0.031421 - 0.021264 ALD5 [1479] "aldehyde dehydrogenase (NAD+), mitochondrial" + 0.031394 - 0.002162 RIB1 [255] GTP cyclohydrolase II + 0.031364 - 0.002541 ECM13 involved in cell wall structure of biosynthesis + 0.005914 - 0.031343 CLN1 "cyclin, G1/S-specific" + 0.031072 - 0.000000 ARO10 [129 134 142 186 267 315 1085 1454] "similarity to Pdc6p, Thi3p and to pyruvate decarboxylases" + 0.030980 - 0.012485 ERG28 [255 671 672 1098 2170 2173 2174] involved in synthesis of ergosterol + 0.030967 - 0.003029 YAL053W "strong similarity to hypothetical proteins YOR365c,YGL139w,YPL221w" + 0.030904 - 0.002156 ISA1 mitochondrial protein required for normal iron metabolism + 0.011391 - 0.030823 SCW11 [368 369 703] similarity to glucanase + 0.001804 - 0.030727 YNR009W hypothetical protein + 0.030562 - 0.004576 TRP3 [127 129 134 136 142 186 255 315 1085 1454] anthranilate synthase component II + 0.030068 - 0.012304 PRY2 [706] similarity to the plant PR-1 class of pathogen related proteins + 0.003027 - 0.029961 CHO1 [255 1098] CDP-diacylglycerol serine O-phosphatidyltransferase + 0.029664 - 0.007675 YLR346C weak similarity to YGR035c + 0.011904 - 0.029628 SRL1 [368 369 703] similarity to vanadate sensitive suppressor Svs1p + 0.029512 - 0.002703 PTP2 protein-tyrosine-phosphatase + 0.029472 - 0.007139 WTM1 transcriptional modulator + 0.029396 - 0.002499 YPL159C weak similarity to YPR151c + 0.029324 - 0.002220 RIM101 meiotic regulatory protein + 0.012917 - 0.029230 VTC3 "strong similarity to YFL004w, similarity to YJL012c" + 0.006875 - 0.029106 CSI2 involved in chitin synthesis + 0.028911 - 0.002622 YOR173W strong similarity to YLR270w + 0.028849 - 0.001351 ESBP6 [1002 1456] similarity to YKL221w and human X-linked PEST-containing transporter + 0.002789 - 0.028741 MCD1 Mitotic Chromosome Determinant + 0.028712 - 0.005636 YER079W hypothetical protein + 0.028580 - 0.004743 YBR012C hypothetical protein + 0.028455 - 0.005795 LYS9 [127 129 134 136 142 205 255 315 1454 1479] "saccharopine dehydrogenase (NADP+, L-glutamate forming)" + 0.028451 - 0.006724 ERG25 [255 671 672 1098 1479 2170 2173 2174] C-4 sterol methyl oxidase + 0.002134 - 0.028364 RKI1 D-ribose-5-phosphate ketol-isomerase + 0.028284 - 0.007728 YJL200C [955 1085] strong similarity to aconitate hydratase + 0.009776 - 0.028256 RPP0 [255 526 527 528 1098 2000 2182 2183] acidic ribosomal protein L10.e + 0.028134 - 0.003219 YLR356W similarity to SCM4 protein + 0.028103 - 0.003170 ACA1 ATF/CREB activator + 0.028063 - 0.000000 YOR024W hypothetical protein + 0.005036 - 0.028025 ELO1 [255 315 1098 1454] fatty acid elongation protein + 0.007797 - 0.027965 YDR133C questionable ORF + 0.002043 - 0.027877 RPS22A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S15a.e.c10 + 0.027783 - 0.004469 BAP2 [1456] "leucine permease, high-affinity (S1)" + 0.027727 - 0.002104 YDL223C weak similarity to mucin + 0.027535 - 0.020556 SVS1 [368 369 703] vanadate sensitive suppressor + 0.027357 - 0.000573 YCL049C similarity to 'unknown protein'; S. pastorianus + 0.027236 - 0.002071 RSM22 [255 1098 2000 2109 2182 2183] similarity to S. pombe SPAC1420.04c putative cytochrome c oxidase assembly protein + 0.001846 - 0.027169 RAS1 GTP-binding protein + 0.027059 - 0.008265 ARG8 [127 129 134 136 142 172 175 255 315 803 805 1343 1351 1454 1466 2372] acetylornithine aminotransferase + 0.027042 - 0.004904 TIR1 [368 369 703 2183] "cold-shock induced protein of the Tir1p,Tip1p family" + 0.026900 - 0.003846 VTH1 "strong similarity to Vth2p and Pep1p, potential membrane glycoprotein" + 0.026750 - 0.001252 PCA1 [331 1002] P-type Cu2+-transporting ATPase + 0.002005 - 0.026743 TAT1 [1456] amino acid permease + 0.017367 - 0.026727 CLN2 "cyclin, G1/S-specific" + 0.026556 - 0.002742 YPS5 similarity to hypothetical aspartyl proteinase YIR039C + 0.026533 - 0.023780 MET3 [129 134 142 205 315 1454 2190 2198 2201 2202] sulfate adenylyltransferase + 0.006606 - 0.026296 YOR315W hypothetical protein + 0.001989 - 0.026207 CUP5 [331 1002] "H+-ATPase V0 domain 17 KD subunit, vacuolar" + 0.026135 - 0.001910 BAS1 [127 129 134 136 142 255 315 1098 1454] transcription factor + 0.026066 - 0.002843 MRP8 [255 1098 2000 2182 2183] "ribosomal protein, mitochondrial" + 0.025954 - 0.002406 YER130C similarity to Msn2p and weak similarity to Msn4p + 0.025919 - 0.000882 YDR186C hypothetical protein + 0.006167 - 0.025910 EGT2 [368 369 703] cell-cycle regulation protein + 0.025882 - 0.000000 HIS1 [127 129 134 136 142 255 315 1454] ATP phosphoribosyltransferase + 0.003787 - 0.025723 HTA1 histone H2A + 0.025617 - 0.003608 YNL115C weak similarity to S.pombe hypothetical protein SPAC23C11 + 0.003728 - 0.025590 RPS22B [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S15a.e.c12 + 0.014215 - 0.025529 SIM1 [368 369 703] involved in cell cycle regulation and aging + 0.002280 - 0.025409 YIL158W similarity to hypothetical protein YKR100c + 0.025243 - 0.004382 MET28 [127 129 134 136 142 255 315 1454 2198 2201] transcriptional activator of sulfur amino acid metabolism + 0.025171 - 0.015624 BAT1 [127 129 134 136 142 255 265 267 315 1454] "branched chain amino acid aminotransferase, mitochondrial" + 0.002127 - 0.025160 SWI5 transcription factor + 0.025113 - 0.009297 PRY1 [706] strong similarity to the plant PR-1 class of pathogen related proteins + 0.025071 - 0.003062 OM45 protein of the outer mitochondrial membrane + 0.024894 - 0.006224 TRP2 [127 129 134 136 142 186 255 315 1085 1454] anthranilate synthase component I + 0.024879 - 0.006574 PRM7 hypothetical protein + 0.024649 - 0.000974 STP2 involved in pre-tRNA splicing + 0.006579 - 0.024407 YNR067C [368 369 703 706] similarity to beta-glucan-elicitor receptor - Glycine max + 0.011499 - 0.024345 HO homothallic switching endonuclease + 0.002621 - 0.024313 CHO2 [255 1098] phosphatidylethanolamine N-methyltransferase + 0.024288 - 0.002828 YIL108W similarity to hypothetical S. pombe protein + 0.024160 - 0.002411 HAP1 transcription factor + 0.024108 - 0.003459 CYC7 cytochrome-c isoform 2 + 0.006052 - 0.024056 YHP1 strong similarity to Yox1p + 0.005891 - 0.024013 CHS2 chitin synthase II + 0.002803 - 0.023962 RPL22A [255 526 527 528 1098 2000 2182 2183] ribosomal protein + 0.023961 - 0.006817 YOR049C [331 1002] "similarity to YER185w, Rta1p" + 0.003433 - 0.023876 ESC4 Establishes Silent Chromatin + 0.023843 - 0.010402 PTR2 peptide transporter + 0.004025 - 0.023741 FUR1 uracil phosphoribosyltransferase + 0.015087 - 0.023672 AGA1 [368 369 703] a-agglutinin anchor subunit + 0.007351 - 0.023658 PMT2 [255 1098] mannosyltransferase + 0.003292 - 0.023565 RPS28B [255 526 528 529 690 691 1098 2000 2109 2182 2183] 40S small subunit ribosomal protein S28.e.c12 + 0.002633 - 0.023544 RPL26B [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.001891 - 0.023416 MKC7 [368 369 703] aspartyl protease of the periplasmic space + 0.002159 - 0.023387 RPL9A [255 526 527 528 1098 2000 2182 2183] ribosomal protein L9.e + 0.007903 - 0.023375 SOD1 [526 1479] copper-zinc superoxide dismutase + 0.023374 - 0.007951 BTN2 [526] Gene/protein whose expression is elevated in a btn1 minus/Btn1p lacking yeast strain + 0.023370 - 0.004139 ATP7 [255 331 1002 1098 2183] "F1F0-ATPase complex, FO D subunit" + 0.003477 - 0.023278 CDS1 [255 1098] CDP-diacylglycerol synthase + 0.023166 - 0.005153 DRE2 weak similarity to C.elegans hypothetical protein + 0.004415 - 0.023025 HHF2 histone H4 + 0.023016 - 0.005771 GAP1 [1456] general amino acid permease + 0.004647 - 0.023015 SCP160 required for maintenance of exact ploidy + 0.022949 - 0.018410 CIS3 [368 369 703 706 2183] strong similarity to Pir1p/Hsp150p/Pir3p family + 0.022889 - 0.006386 RNY1 [706] similarity to ribonucleases + 0.022778 - 0.009618 CYB5 [255 1098 2170 2173 2174] cytochrome b5 + 0.022762 - 0.002884 YKL202W questionable ORF + 0.016552 - 0.022691 YHL029C hypothetical protein + 0.022680 - 0.003209 GLN3 [526 1343] transcription factor for positive nitrogen regulation + 0.022584 - 0.002297 YMR184W hypothetical protein + 0.022577 - 0.000000 YBR262C questionable ORF + 0.022573 - 0.006621 RFX1 repressor of DNA damage-inducible genes + 0.001865 - 0.022534 YLR049C hypothetical protein + 0.022501 - 0.003463 PDE2 "high affinity 3',5'-cyclic-nucleotide phosphodiesterase" + 0.022407 - 0.006650 SDH1 [1479] succinate dehydrogenase flavoprotein precursor + 0.022274 - 0.001710 YMC1 mitochondrial carrier protein (MCF) + 0.022200 - 0.019470 OAC1 [331 1002 1456] similarity to mitochondrial uncoupling proteins (MCF) + 0.002623 - 0.022151 ASE1 microtubule-associated protein (nonmotor) + 0.010578 - 0.022042 YDR134C [368 369 703] "strong similarity to Flo1p, Flo5p, Flo9p and YLR110c" + 0.000000 - 0.022018 RPS21A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S21.e + 0.022000 - 0.001804 LPE10 [331 1002] strong similarity to Mrs2p + 0.007865 - 0.021965 NCE102 involved in non-classical protein export pathway + 0.021916 - 0.003851 NRG1 transcriptional repressor for glucose repression of STA1 gene expression + 0.021910 - 0.007060 ICY1 similarity to ICY2 + 0.021898 - 0.000000 HXT5 member of the hexose transporter family + 0.021873 - 0.001520 MAC1 metal binding activator + 0.021821 - 0.004357 NGR1 glucose-repressible RNA-binding protein + 0.021812 - 0.002843 YHR213W "strong similarity to Flo5p, Flo1p, Flo9p - putative pseudogene" + 0.021743 - 0.003480 CAR1 [129 134 142 175 315 526 805 1343 1351 1454 1466 2372] arginase + 0.021626 - 0.003409 YMR040W strong similarity to Yet1p + 0.021599 - 0.001307 YFL057C [1479] strong similarity to aryl-alcohol dehydrogenases + 0.008726 - 0.021573 FKS1 [255 1098] "1,3-beta-D-glucan synthase, catalytic subunit" + 0.021567 - 0.002972 GRX1 [1479] glutaredoxin + 0.021562 - 0.002603 HSP42 heat shock protein + 0.000000 - 0.021552 RAX2 [368 369 703] weak similarity to Pst1p + 0.005481 - 0.021531 HHO1 histone H1 protein + 0.021522 - 0.001339 RPN4 [526] 26S proteasome subunit + 0.021513 - 0.009258 INH1 [255 1098] inhibitor of mitochondrial ATPase + 0.008572 - 0.021496 CST13 weak similarity to TRCDSEMBL:AF176518_1 F-box protein FBL2; human + 0.021412 - 0.009601 ADE3 [255 315 1098 1454 1479] "C1-tetrahydrofolate synthase (trifunctional enzyme),cytoplasmic" + 0.021409 - 0.003599 ERG26 [255 671 672 1098 1479 2170 2173 2174] C-3 sterol dehydrogenase (C-4 decarboxylase) + 0.021367 - 0.003186 AAP1' [255 331 1002 1098] alanine/arginine aminopeptidase + 0.003661 - 0.021360 YOR264W hypothetical protein + 0.003034 - 0.021260 AUR1 aureobasidin-resistance protein + 0.003014 - 0.021245 PRY3 [368 369 703] strong similarity to the plant PR-1 class of pathogen related proteins + 0.021238 - 0.003844 PLB3 [706] phospholipase B (lysophospholipase) + 0.021230 - 0.007533 GPR1 G-protein coupled receptor + 0.021230 - 0.006819 HSP104 heat shock protein + 0.021181 - 0.004966 RIP1 [331 1002 1479] ubiquinol--cytochrome-c reductase iron-sulfur protein precursor + 0.001866 - 0.021127 BUD28 questionable ORF + 0.021103 - 0.009383 HSP30 heat shock protein + 0.001637 - 0.021083 FAA3 [255 1098] acyl CoA synthase + 0.000796 - 0.021059 ALG5 [255 1098] dolichol-P-glucose synthetase + 0.002182 - 0.021037 RPL30 [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein L30.e + 0.021026 - 0.003509 YIL023C similarity to mouse MHC H-2K/t-w5-linked ORF precursor + 0.004070 - 0.021010 PMA1 [331 1002] "H+-transporting P-type ATPase, major isoform, plasma membrane" + 0.020967 - 0.008286 YDL124W similarity to aldose reductases + 0.020648 - 0.008072 LYS4 [127 129 134 136 142 205 255 315 955 1085 1454] homoaconitase + 0.020547 - 0.003455 SGE1 drug resistance protein + 0.001096 - 0.020497 BBP1 [2183] cell division control protein + 0.020465 - 0.001567 YJR149W similarity to 2-nitropropane dioxygenase + 0.020418 - 0.000000 TGL2 triacylglycerol lipase + 0.020393 - 0.006650 YFR017C hypothetical protein + 0.020384 - 0.004503 YLR266C weak similarity to transcription factors + 0.002189 - 0.020372 SEN34 tRNA splicing endonuclease gamma subunit + 0.003911 - 0.020366 RPS3 [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S3.e + 0.020327 - 0.001733 DLD1 [1479] D-lactate ferricytochrome C oxidoreductase (D-LCR) + 0.002434 - 0.020314 RPS31 [255 526 528 529 690 691 1098 2000 2109 2182 2183] ubiquitin/40S small subunit ribosomal protein + 0.020277 - 0.006367 YGR243W strong similarity to hypothetical protein YHR162w + 0.001886 - 0.020261 YLR112W hypothetical protein + 0.020194 - 0.002407 YGR250C weak similarity to human cleavage stimulation factor 64K chain + 0.003577 - 0.020170 ASH1 negative regulator of HO transcription + 0.002334 - 0.020100 RPL25 [255 526 527 528 1098 2000 2182 2183] ribosomal protein L23a.e + 0.002816 - 0.020094 RPS10A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S10.e + 0.020075 - 0.008536 COS8 strong similarity to subtelomeric encoded proteins + 0.004981 - 0.019939 HCM1 transcription factor + 0.010478 - 0.019868 VTC1 Negative Regulator of Cdc Fourty two (Cdc42) + 0.019844 - 0.003094 YJL038C strong similarity to hypothetical protein YJL037w + 0.019764 - 0.003727 MIR1 "phosphate transport protein, mitochondrial (MCF)" + 0.019751 - 0.006476 LAP4 "aminopeptidase yscI precursor, vacuolar" + 0.004222 - 0.019730 IMD4 [1479] strong similarity to IMP dehydrogenases + 0.019701 - 0.004519 SNQ2 multidrug resistance protein + 0.019690 - 0.003704 RTG3 bHLH/zip transcription factor that regulates CIT2 gene expression + 0.003501 - 0.019684 EFB1 [255 1098 2000] translation elongation factor eEF1beta + 0.002437 - 0.019675 RPS13 [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein + 0.008953 - 0.019663 YOX1 homoeodomain protein + 0.019653 - 0.000000 FUS1 cell fusion protein + 0.019643 - 0.007501 YJL217W similarity to conserved hypothetical protein VCA0345 Vibrio cholerae + 0.019628 - 0.004541 GLT1 [127 129 134 136 142 255 315 803 805 1454 1479] glutamate synthase (NAPDPH) (GOGAT) + 0.007938 - 0.019566 ZMS1 transcription factor with similarity to regulatory protein Ard1p + 0.019548 - 0.003530 YCR106W similarity to transcription factor + 0.003580 - 0.019539 CDC6 cell division control protein + 0.004396 - 0.019526 TOS3 "strong similarity to Pak1p, Elm1p and Kin82p" + 0.019523 - 0.001779 PFK27 "6-phosphofructose-2-kinase, isoenzyme 2" + 0.019513 - 0.005086 TPS1 "alpha,alpha-trehalose-phosphate synthase, 56 KD subunit" + 0.014371 - 0.019505 FUS3 mitogen-activated protein kinase (MAP kinase) + 0.019484 - 0.004346 SDH2 [1479] succinate dehydrogenase iron-sulfur protein subunit + 0.019436 - 0.006854 ILV1 [127 129 134 136 142 255 265 267 315 1085 1454] anabolic serine and threonine dehydratase precursor + 0.000498 - 0.019425 ZRC1 [331 1002 2201] zinc- and cadmium resistance protein + 0.003846 - 0.019330 SWI4 transcription factor + 0.019309 - 0.008674 ERG6 [255 671 672 1098 2170 2173 2174] S-adenosyl-methionine delta-24-sterol-c-methyltransferase + 0.019241 - 0.001561 ENA2 [331 1002] P-type ATPase involved in Na+ efflux + 0.005670 - 0.019222 CEM1 [255] "beta-keto-acyl-ACP synthase, mitochondrial" + 0.003974 - 0.019144 YOR271C strong similarity to Rattus tricarboxylate carrier + 0.002436 - 0.019025 RPS12 [255 526 528 529 690 691 1098 2000 2109 2182 2183] 40S small subunit acidic ribosomal protein S12 + 0.001631 - 0.019017 REB1 transcription factor + 0.001904 - 0.018994 RPS29A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S29.e.A + 0.016952 - 0.018958 YLR179C similarity to Tfs1p + 0.002269 - 0.018892 PSD1 [255 1085 1098] phosphatidylserine decarboxylase 1 + 0.018829 - 0.005581 STB4 "weak similarity to YIL130w, Put3p and other transcription factors" + 0.002082 - 0.018817 RPL9B [255 526 527 528 1098 2000 2182 2183] ribosomal protein L9.e.c14 + 0.003601 - 0.018816 RPS1B [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S3a.e + 0.006405 - 0.018811 RPS15 [255 526 528 529 690 691 1098 2000 2109 2182 2183] 40S small subunit ribosomal protein + 0.018804 - 0.002226 ATP15 [255 331 1002 1098] "F1F0-ATPase complex, F1 epsilon subunit" + 0.002669 - 0.018795 RPS5 [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S5.e + 0.002833 - 0.018793 RPL14A [255 526 527 528 1098 2000 2182 2183] ribosomal protein + 0.018706 - 0.000000 YMR244C-A questionable ORF + 0.004091 - 0.018698 PHD1 transcription factor + 0.002883 - 0.018697 RPL38 [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.018680 - 0.001257 COX9 [331 1002 1479] cytochrome-c oxidase chain VIIA + 0.018672 - 0.002390 ICS3 hypothetical protein + 0.002488 - 0.018668 RPS26B [255 526 528 529 690 691 1098 2000 2109 2182 2183] 40S small subunit ribosomal protein S26e-c5 + 0.004154 - 0.018664 HXK2 [526] hexokinase II + 0.003387 - 0.018652 ERP3 weak similarity to Dep1p + 0.018604 - 0.001636 COX13 [331 1002 1479] cytochrome-c oxidase chain VIa + 0.018557 - 0.003965 QCR9 [331 1002 1479] ubiquinol--cytochrome-c reductase subunit 9 + 0.018526 - 0.004702 CAR2 [129 134 142 175 315 805 1343 1454 2372] ornithine aminotransferase + 0.018510 - 0.001843 USV1 "similarity to Rgm1p, weak similarity to transcription factors" + 0.002182 - 0.018492 RPL20A [255 526 527 528 1098 2000 2182 2183] 60s large subunit ribosomal protein + 0.004073 - 0.018438 YMR144W weak similarity to Mlp1p + 0.018407 - 0.006627 YGR146C hypothetical protein + 0.003637 - 0.018383 YGR086C strong similarity to hypothetical protein YPL004c + 0.018330 - 0.011570 YBR071W hypothetical protein + 0.003399 - 0.018306 YDL193W similarity to N.crassa hypothetical 32 kDa protein + 0.002437 - 0.018283 RPL24A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein L24.e.A + 0.003476 - 0.018240 GIN4 ser/thr protein kinase + 0.002026 - 0.018218 RPL26A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.018192 - 0.003344 BGL2 [368 369 703] "endo-beta-1,3-glucanase of the cell wall" + 0.003007 - 0.018191 HLR1 similarity to Lre1p + 0.005012 - 0.018161 RPL37B [255 526 527 528 1098 2000 2182 2183] ribosomal protein L.37.e + 0.003095 - 0.018109 YJL051W hypothetical protein + 0.018081 - 0.011025 GRE2 [1479] similarity to plant dihydroflavonol-4-reductases + 0.018025 - 0.002584 YJL171C [368 369 703] similarity to YBR162c + 0.018005 - 0.005864 ZWF1 [1479] glucose-6-phosphate dehydrogenase + 0.002632 - 0.017965 RPS6A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S6.e + 0.002122 - 0.017945 RPL35A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.017930 - 0.007489 SHM2 "serine hydroxymethyltransferase, cytoplasmic" + 0.017900 - 0.003114 YGL114W weak similarity to H.influenzae permease + 0.017863 - 0.003698 MID2 mating process protein + 0.017828 - 0.010899 COS4 strong similarity to subtelomeric encoded proteins + 0.017798 - 0.010089 YOR108W [127 129 134 136 142 255 265 267 315 1454] strong similarity to Leu4p + 0.017762 - 0.002330 YHR033W strong similarity to glutamate 5-kinase + 0.017761 - 0.004440 DFG5 [255] "required for filamentous growth, cell polarity, and cellular elongation" + 0.002738 - 0.017756 RPL21B [255 526 527 528 1098 2000 2182 2183] ribosomal protein L21 + 0.017728 - 0.017361 YRO2 strong similarity to HSP30 heat shock protein Yro1p + 0.002015 - 0.017706 RPL35B [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.008702 - 0.017674 GSP1 GTP-binding protein of the ras superfamily + 0.017648 - 0.014533 YGR035C hypothetical protein + 0.017631 - 0.004386 ADE8 [255 1098] phosphoribosylglycinamide formyltransferase (GART) + 0.017606 - 0.003596 MSS4 phosphatidylinositol-4-phosphate 5-kinase + 0.017580 - 0.009623 COS5 strong similarity to subtelomeric encoded proteins + 0.003785 - 0.017569 RPS1A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S3a.e + 0.003110 - 0.017508 RPS0B [255 526 528 529 690 691 1098 2000 2109 2182 2183] 40S ribosomal protein p40 homolog B + 0.017489 - 0.011528 YEL045C weak similarity to cytochrome c oxidase III of T.brucei kinetoplast + 0.004013 - 0.017469 RPL12A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein L12.e + 0.017464 - 0.003572 ARG2 [127 129 134 136 142 172 175 255 315 803 805 1343 1351 1454 1466 2372] acetylglutamate synthase + 0.015874 - 0.017456 GIC2 Cdc42 GTPase-binding protein + 0.017442 - 0.008418 GCN4 [127 129 134 136 142 255 315 1454] transcriptional activator of amino acid biosynthetic genes + 0.017416 - 0.011184 COS6 strong similarity to subtelomeric encoded proteins + 0.017394 - 0.016450 CYS3 [129 134 142 315 1085 1454 2198 2201] cystathionine gamma-lyase + 0.002475 - 0.017380 GPM1 [255 526 1098] phosphoglycerate mutase + 0.002583 - 0.017377 RPS27A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S27.e + 0.017350 - 0.004217 YHR199C strong similarity to hypothetical protein YHR198c + 0.016234 - 0.017337 SCW10 [368 369 703] similarity to B.japonicum putative beta-(-6)glucan transferase + 0.017321 - 0.000950 TCM10 hypothetical protein + 0.005376 - 0.017276 YPL278C strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.002563 - 0.017257 SPO16 sporulation protein + 0.004918 - 0.017251 PRP43 involved in spliceosome disassembly + 0.017236 - 0.003112 ATP1 [255 331 1002 1098] "F1F0-ATPase complex, F1 alpha subunit" + 0.017230 - 0.002800 ATP3 [255 331 1002 1098] "F1F0-ATPase complex, F1 gamma subunit" + 0.007116 - 0.017183 BUD9 budding protein + 0.003097 - 0.017163 KEL2 involved in cell fusion and morphogenesis + 0.017139 - 0.002233 MNN4 [255 1098] regulates the mannosylphosphorylation + 0.017098 - 0.002040 RPH1 similarity to human retinoblastoma binding protein 2 + 0.017026 - 0.001855 YIL176C strong similarity to members of the Srp1p/Tip1p family + 0.002301 - 0.016993 RFA1 "DNA replication factor A, 69 KD subunit" + 0.005232 - 0.016975 BUD4 budding protein + 0.002892 - 0.016944 RPS8A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S8.e + 0.003272 - 0.016941 MDM20 necessary for mitochondrial inheritance and organisation of the actin cytoskeleton + 0.002732 - 0.016913 RPS2 [255 526 528 529 690 691 1098 2000 2109 2182 2183] 40S small subunit ribosomal protein + 0.016912 - 0.005278 ODC2 [1456] similarity to ADP/ATP carrier proteins + 0.016910 - 0.010987 COS1 strong similarity to subtelomeric encoded proteins + 0.001396 - 0.016896 SUB2 probably involved in pre-mRNA splicing + 0.001620 - 0.016889 VAC8 required for vacuole inheritance and protein targeting from the cytoplasm to vacuole + 0.016880 - 0.004319 YGL186C similarity to hypothetical protein Fcy21p and weak similarity to FCY2 protein + 0.016865 - 0.010321 COS3 strong similarity to subtelomeric encoded proteins + 0.016814 - 0.004654 RAD59 recombination and DNA repair protein + 0.016811 - 0.010383 RME1 zinc-finger transcription factor + 0.016753 - 0.003290 ROT1 mutant suppresses tor2 mutation + 0.002330 - 0.016716 RPS18B [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S18.e.c13 + 0.016671 - 0.000000 DAL1 [129] allantoinase + 0.007588 - 0.016635 CDC19 [315 526 1454] pyruvate kinase + 0.016608 - 0.012038 YOL155C [368 369 703 706] "similarity to glucan 1,4-alpha-glucosidase Sta1p and YAR066w" + 0.002088 - 0.016546 RPS20 [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein + 0.016521 - 0.005748 MCT1 [315 1454] malonyl-CoA:ACP transferase + 0.016519 - 0.006042 YCR100C "strong similarity to Pep1p, VTH1p and VTH22p" + 0.016505 - 0.008334 YPL251W questionable ORF + 0.005303 - 0.016479 YER156C similarity to hypothetical C. elegans protein C27H6.5 + 0.002747 - 0.016446 RPL21A [255 526 527 528 1098 2000 2182 2183] ribosomal protein L21.e + 0.016443 - 0.007463 HXT6 high-affinity hexose transporter + 0.016419 - 0.001127 YIR041W similarity to members of the Srp1p/Tip1p family + 0.002377 - 0.016394 RPL23B [255 526 527 528 1098 2000 2182 2183] ribosomal protein L23.e + 0.004521 - 0.016368 SAM1 [129 134 142 205 315 1454 2198 2201] S-adenosylmethionine synthetase 1 + 0.002300 - 0.016351 BUD19 questionable ORF + 0.016306 - 0.002334 YDL173W hypothetical protein + 0.002257 - 0.016303 QRI2 weak similarity to proteins of unknown function + 0.005503 - 0.016285 YLR400W hypothetical protein + 0.016278 - 0.003250 MET4 [129 134 142 315 1454 2198 2201] transcriptional activator of sulfur metabolism + 0.002582 - 0.016211 KRE35 similarity to putative human GTP-binding protein MMR1 + 0.016190 - 0.004327 YJL060W [255 1098] similarity to kynurenine aminotransferase and glutamine-phenylpyruvate transaminase + 0.002789 - 0.016184 RPS25A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S25.e.c7 + 0.016177 - 0.002849 MKK2 protein kinase of the map kinase kinase (MEK) family + 0.016168 - 0.003740 MTH1 repressor of hexose transport genes + 0.016140 - 0.004823 CHS1 chitin synthase I + 0.015621 - 0.016137 MFA2 [706] mating pheromone a-factor 2 + 0.001248 - 0.016074 EPT1 [127 129 134 255 1098] "sn-1,2-diacylglycerol ethanolamine- and cholinephosphotransferase" + 0.003525 - 0.016038 RPL40A [255 526 527 528 1098 2000 2182 2183] ubiquitin + 0.003187 - 0.016037 YCL063W weak similarity to yeast translation regulator Gcd6p + 0.015982 - 0.007055 YDR341C [255 1098] "arginyl-tRNA synthetase, cytosolic" + 0.002664 - 0.015965 GPX2 [1479] glutathione peroxidases + 0.003027 - 0.015941 YPL158C weak similarity to human nucleolin + 0.015941 - 0.007747 YNL057W questionable ORF + 0.003054 - 0.015924 RPL16A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.001603 - 0.015903 APA1 ATP adenylyltransferase I + 0.005782 - 0.015897 DIP5 [1456] dicarboxylic amino acid permease + 0.002703 - 0.015887 TDH3 [255 368 369 526 703 1098 1479] glyceraldehyde-3-phosphate dehydrogenase 3 + 0.004713 - 0.015875 RPS4A [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S4.e.c10 + 0.015872 - 0.006648 TOS5 hypothetical protein + 0.015858 - 0.001788 SNG1 involved in nitroguanidine resistance + 0.003439 - 0.015814 YIL135C similarity to Ymk1p + 0.008832 - 0.015803 YAP1 transcriptional activator involved in oxidative stress response + 0.015798 - 0.005571 YOR302W [255 526 1098] CPA1 leader peptide + 0.015794 - 0.006479 YRF1-3 strong similarity to YPL283c; YNL339c and other Y' encoded proteins + 0.015782 - 0.005931 YRF1-6 nearly identical to other subtelomerically encoded putative helicases + 0.015775 - 0.005030 SSA4 "heat shock protein of HSP70 family, cytosolic" + 0.015735 - 0.003458 RNR2 [1479] "ribonucleoside-diphosphate reductase, small subunit" + 0.015731 - 0.001989 YKL051W [127 129 134 255 1098] weak similarity to hypothetical protein S. pombe + 0.015704 - 0.003391 YLR294C questionable ORF + 0.015693 - 0.006693 COX5B [331 1002 1479] cytochrome-c oxidase chain Vb + 0.003553 - 0.015671 HHF1 histone H4 + 0.004303 - 0.015668 SWE1 ser/tyr dual-specifity protein kinase + 0.003012 - 0.015660 RPL23A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein L23.e + 0.004496 - 0.015625 TDH2 [255 368 369 526 703 1098 1479] glyceraldehyde-3-phosphate dehydrogenase 2 + 0.014465 - 0.015610 CCW12 [368 369 703] strong similarity to Flo1p + 0.015602 - 0.004288 YJL160C strong similarity to Pir1p/Hsp150p/Pir3p family + 0.001898 - 0.015586 ERS1 [1456] intracellular protein transport protein + 0.002960 - 0.015576 SSH1 involved in co-translational pathway of protein transport + 0.002166 - 0.015551 RPS29B [255 526 528 529 690 691 1098 2000 2109 2182 2183] ribosomal protein S29.e.B + 0.002743 - 0.015548 RPL20B [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.002680 - 0.015545 RPL6A [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein + 0.003026 - 0.015537 YMR093W weak similarity to Pwp2p + 0.004555 - 0.015529 FAS1 [255 315 526 955 1085 1098 1454 1479] "fatty-acyl-CoA synthase, beta chain" + 0.015513 - 0.006552 HMLALPHA2 "mating type regulatory protein, silenced copy at HML" + 0.015500 - 0.000000 FAT2 "AMP-binding protein, peroxisomal" + 0.015496 - 0.003629 TOS10 hypothetical protein + 0.003891 - 0.015491 RPL5 [255 526 527 528 1098 2000 2182 2183] 60S large subunit ribosomal protein L5.e + 0.015480 - 0.005864 YGL157W [1479] similarity to V.vinifera dihydroflavonol 4-reductase + 0.002262 - 0.015477 RPL11A [255 526 527 528 1098 2000 2182 2183] ribosomal protein L11.e + 0.006195 - 0.015471 YGR210C similarity to M.jannaschii GTP-binding protein and to M.capricolum hypothetical protein SGC3 + 0.015470 - 0.011566 YNL134C [1479] similarity to C.carbonum toxD gene + 0.004052 - 0.015462 NOP58 required for pre-18S rRNA processing + 0.001937 - 0.015460 RPL11B [255 526 527 528 1098 2000 2182 2183] ribosomal protein + 0.015451 - 0.004235 AYT1 strong similarity to Gibberella zeae trichothecene 3-O-acetyltransferase Cluster 47: 18 genes GO term [467]: conjugation 0.00e+000 categ GO cluster 10 16 microarray 46 1908 GO term [468]: conjugation with cellular fusion 0.00e+000 categ GO cluster 10 16 microarray 46 1908 GO term [2078]: sexual reproduction 0.00e+000 categ GO cluster 10 16 microarray 46 1908 GO term [1931]: reproduction 2.30e-011 categ GO cluster 10 16 microarray 73 1908 GO term [1957]: response to pheromone 4.96e-011 categ GO cluster 8 16 microarray 34 1908 GO term [1942]: response to chemical substance 2.24e-009 categ GO cluster 8 16 microarray 53 1908 GO term [1938]: response to abiotic stimulus 2.89e-009 categ GO cluster 9 16 microarray 82 1908 GO term [543]: development 1.07e-008 categ GO cluster 11 16 microarray 179 1908 GO term [1958]: response to pheromone during conjugation with cellular fusion 1.13e-008 categ GO cluster 6 16 microarray 23 1908 GO term [1949]: response to external stimulus 1.34e-008 categ GO cluster 9 16 microarray 97 1908 GO term [346]: cell communication 2.51e-008 categ GO cluster 8 16 microarray 71 1908 GO term [2093]: signal transduction during conjugation with cellular fusion 1.57e-006 categ GO cluster 4 16 microarray 12 1908 GO term [1963]: response to stimulus 2.11e-006 categ GO cluster 9 16 microarray 172 1908 GO term [2092]: signal transduction 3.85e-006 categ GO cluster 6 16 microarray 58 1908 GO term [859]: G-protein coupled receptor protein signaling pathway 4.27e-006 categ GO cluster 4 16 microarray 15 1908 GO term [367]: cell surface receptor linked signal transduction 9.42e-006 categ GO cluster 4 16 microarray 18 1908 GO term [2081]: shmoo tip 9.42e-006 categ GO cluster 4 16 microarray 18 1908 GO term [2091]: signal transducer activity 4.42e-005 categ GO cluster 4 16 microarray 26 1908 GO term [1560]: pheromone activity 1.97e-004 categ GO cluster 2 16 microarray 3 1908 GO term [1860]: receptor binding 1.97e-004 categ GO cluster 2 16 microarray 3 1908 GO term [383]: cellular process 3.05e-004 categ GO cluster 14 16 microarray 821 1908 GO term [1863]: receptor signaling protein serine/threonine kinase activity 3.92e-004 categ GO cluster 2 16 microarray 4 1908 GO term [2101]: site of polarized growth 9.32e-004 categ GO cluster 4 16 microarray 56 1908 GO term [2102]: site of polarized growth (sensu Fungi) 9.32e-004 categ GO cluster 4 16 microarray 56 1908 GO term [2103]: site of polarized growth (sensu Saccharomyces) 9.32e-004 categ GO cluster 4 16 microarray 56 1908 GO term [1862]: receptor signaling protein activity 9.70e-004 categ GO cluster 2 16 microarray 6 1908 * TF STE12 (7 / 40 38.89%) transcriptional activator STE12 SST2 TEC1 FUS1 KAR4 GPA1 MFA2 TF MCM1 (4 / 73 22.22%) transcription factor of the MADS box family MFA1 STE6 MFA2 AGA1 TF PHD1 (2 / 74 11.11%) transcription factor PRR2 GPA1 + 0.000000 - 0.970648 PRR2 [346 383 1862 1863 2091 2092] strong similarity to putative protein kinase NPR1 + 0.000000 - 0.146131 YDL133W hypothetical protein + 0.000000 - 0.132290 FUS1 [383 467 468 543 1931 2078 2081 2101 2102 2103] cell fusion protein + 0.064781 - 0.000229 PRY3 strong similarity to the plant PR-1 class of pathogen related proteins + 0.000000 - 0.056725 FIG1 [383 467 468 543 1931 1938 1942 1949 1957 1958 1963 2078 2081 2101 2102 2103] required for efficient mating + 0.000000 - 0.040888 AGA1 [346 383 467 468 543 1931 1938 1942 1949 1957 1958 1963 2078] a-agglutinin anchor subunit + 0.029486 - 0.000000 HSP12 [346 383 1938 1949 1963] heat shock protein + 0.000000 - 0.027441 MFA2 [346 367 383 467 468 543 859 1560 1860 1931 1938 1942 1949 1957 1958 1963 2078 2091 2092 2093] mating pheromone a-factor 2 + 0.000000 - 0.023362 GPA1 [346 367 383 467 468 543 859 1931 1938 1942 1949 1957 1958 1963 2078 2092 2093] GTP-binding protein alpha subunit of the pheromone pathway + 0.000000 - 0.022420 ??? ??? + 0.000062 - 0.022318 STE6 [383 2081 2101 2102 2103] ATP-binding cassette transporter protein + 0.000000 - 0.020931 STE12 [383 467 468 543 1931 1938 1942 1949 1957 1963 2078] transcriptional activator + 0.000000 - 0.020907 FUS3 [346 367 383 467 468 543 859 1862 1863 1931 1938 1942 1949 1957 1958 1963 2078 2081 2091 2092 2093 2101 2102 2103] mitogen-activated protein kinase (MAP kinase) + 0.000000 - 0.020485 MFA1 [346 367 383 467 468 543 859 1560 1860 1931 1938 1942 1949 1957 1958 1963 2078 2091 2092 2093] mating pheromone a-factor 1 + 0.000000 - 0.020241 SST2 [346 383 467 468 543 1931 1938 1942 1949 1957 1963 2078 2092] involved in desensitization to alpha-factor pheromone + 0.000000 - 0.020059 YLR343W strong similarity to Gas1p and C.albicans pH responsive protein + 0.000000 - 0.019342 TEC1 [383 543] Ty transcription activator + 0.000103 - 0.018020 KAR4 [383 467 468 543 1931 2078] regulatory protein required for pheromone induction of karyogamy genes Cluster 48: 15 genes GO term [388]: cellular_component unknown 1.37e-004 categ GO cluster 6 9 microarray 220 1908 TF SWI6 (2 / 84 13.33%) transcription factor YGL239C YMR306C-A TF CIN5 (2 / 129 13.33%) transcriptional activator YHL041W ISF1 TF SWI4 (2 / 116 13.33%) transcription factor YLR255C YMR306C-A TF SWI5 (2 / 84 13.33%) transcription factor YDR543C YNL269W TF NRG1 (2 / 68 13.33%) transcriptional repressor for glucose repression of STA1 gene expression SNO3 YHL041W TF IME4 (2 / 33 13.33%) positive transcription factor for IME2 SNO3 YNL269W + 0.385095 - 0.000379 SNO3 [388] strong similarity to SNO1 and SNO2 + 0.384827 - 0.000364 YNL269W [388] hypothetical protein + 0.384633 - 0.000131 YMR306C-A questionable ORF + 0.384568 - 0.000160 YPL150W [388] similarity to ser/thr protein kinases + 0.384556 - 0.000257 ISF1 [388] involved in suppression of mitochondrial splicing defect + 0.384390 - 0.000150 YLR031W [388] similarity to hypothetical protein YMR124w + 0.241818 - 0.000379 YHL041W weak similarity to Drosophila hypothetical protein 6 + 0.177806 - 0.000063 YLR415C [388] questionable ORF + 0.000072 - 0.118143 HST3 silencing protein + 0.039688 - 0.000181 YDR543C strong similarity to subtelomeric encoded proteins + 0.000000 - 0.038647 UGA3 transcriptional activator for GABA catabolic genes + 0.000000 - 0.031301 BRN1 functional homologue of human BRRN1 + 0.031168 - 0.000182 YLR255C hypothetical protein + 0.019864 - 0.000000 YOR029W hypothetical protein + 0.016026 - 0.000000 YGL239C questionable ORF Cluster 49: 144 genes GO term [388]: cellular_component unknown 0.00e+000 categ GO cluster 48 138 microarray 220 1908 GO term [302]: carbohydrate transport 1.06e-005 categ GO cluster 7 138 microarray 13 1908 GO term [254]: biological_process unknown 1.21e-005 categ GO cluster 51 138 microarray 411 1908 GO term [788]: glucose transporter activity 2.12e-005 categ GO cluster 6 138 microarray 10 1908 GO term [897]: hexose transport 2.12e-005 categ GO cluster 6 138 microarray 10 1908 GO term [898]: hexose transporter activity 2.12e-005 categ GO cluster 6 138 microarray 10 1908 GO term [1251]: monosaccharide transport 2.12e-005 categ GO cluster 6 138 microarray 10 1908 GO term [1252]: monosaccharide transporter activity 2.12e-005 categ GO cluster 6 138 microarray 10 1908 GO term [303]: carbohydrate transporter activity 8.27e-005 categ GO cluster 6 138 microarray 12 1908 GO term [343]: cell adhesion 8.65e-005 categ GO cluster 5 138 microarray 8 1908 GO term [1621]: plasma membrane 9.35e-005 categ GO cluster 19 138 microarray 104 1908 GO term [750]: fructose transporter activity 1.83e-004 categ GO cluster 5 138 microarray 9 1908 GO term [1117]: mannose transporter activity 1.83e-004 categ GO cluster 5 138 microarray 9 1908 GO term [289]: calcium-dependent cell-cell adhesion 3.71e-004 categ GO cluster 3 138 microarray 3 1908 GO term [735]: flocculation 3.71e-004 categ GO cluster 3 138 microarray 3 1908 GO term [736]: flocculation (sensu Saccharomyces) 3.71e-004 categ GO cluster 3 138 microarray 3 1908 GO term [1115]: mannose binding 3.71e-004 categ GO cluster 3 138 microarray 3 1908 GO term [1247]: monosaccharide binding 3.71e-004 categ GO cluster 3 138 microarray 3 1908 GO term [2187]: sugar binding 3.71e-004 categ GO cluster 3 138 microarray 3 1908 GO term [377]: cell-cell adhesion 7.73e-004 categ GO cluster 4 138 microarray 7 1908 * TF CIN5 (25 / 129 17.36%) transcriptional activator YAP6 AQY2 FLO9 ECM13 HXT6 YER028C ACA1 YGR035C RNR4 YHL041W YHR049W YIL172C FSP2 YJR061W GAP1 GAL2 ATR1 YML131W ISF1 GRE2 HXT11 YOL157C YOR049C YPL062W CTR1 * TF PHD1 (24 / 74 16.67%) transcription factor MSN4 FLO9 RRN10 GIT1 YCR100C PRR2 HXT15 HXT6 CYC7 HXT13 ACA1 YHR213W YIL175W YJL105W YJL217W YJL218W FSP2 HXT16 SOR1 FLO10 ATR1 YML131W ICY1 YPR013C * TF NRG1 (23 / 68 15.97%) transcriptional repressor for glucose repression of STA1 gene expression NRG1 YAP6 HXT15 YDL246C STL1 HXT13 TIR1 ACA1 YHL041W YHR033W YIL172C GAT4 YIR014W YJL216C FSP2 HXT16 SOR1 FLO10 YLR012C HXT11 YOL157C YOR049C YPR013C * TF YAP6 (23 / 75 15.97%) "transcription factor, of a fungal-specific family of bzip proteins" CIN5 YAP6 AQY2 FLO9 HXT15 YDL246C ACA1 YIL172C GAT4 YIR014W MUC1 YJL216C YJL217W FSP2 HXT16 SOR1 FLO10 GAL2 ATR1 HXT11 YOL157C YOR049C YPR013C TF SKN7 (11 / 83 7.64%) transcription factor with similarity to Hsf1p NRG1 FLO1 NRG2 TIR1 MUC1 YJR078W DDR48 MDG1 YOL154W YPR009W HOR7 * TF SMP1 (11 / 55 7.64%) MADS-box transcription factor SMP1 YPC1 TIR1 YPS5 YIL175W GAT4 YIR014W FLO10 YKR105C EXG1 CTR1 TF YJL206C (7 / 20 4.86%) similarity to YIL130p and Put3p YNR071C FDH1 YPL275W YPL276W YPL277C YPL278C YPR013C TF MCM1 (6 / 73 4.17%) transcription factor of the MADS box family YMR253C FDH1 YPL275W YPL276W YPL277C YPL278C TF RLM1 (6 / 32 4.17%) transcription factor of the MADS box family HXT15 YDL246C YPS5 YHL041W HXT16 EXG1 TF GCN4 (5 / 72 3.47%) transcriptional activator of amino acid biosynthetic genes NPR2 FLO1 RIM9 KAR5 ICY1 TF SUM1 (5 / 48 3.47%) suppressor of SIR mutations DTR1 DIT2 DIT1 SPS2 YJR078W TF SOK2 (5 / 11 3.47%) regulatory protein in the PKA signal transduction pathway YAP6 HXT15 YJL216C HXT16 SOR1 TF CUP9 (5 / 16 3.47%) involved in copper homeostasis repression of protein import YAP6 ECM13 YDL246C HXT16 SOR1 TF ROX1 (5 / 23 3.47%) heme-dependent transcriptional repressor of hypoxic genes YAP6 HXT15 YDL246C HXT16 SOR1 TF FHL1 (5 / 166 3.47%) transcriptional activator of the forkhead/hnf3 family RPS24A UGO1 RTA1 DUR3 YOR292C TF HAL9 (4 / 16 2.78%) transcriptional activator of ENA1 MSN4 YCR102C YLR460C PHM7 TF MET31 (4 / 28 2.78%) transcriptional regulator of sulfur amino acid metabolism SPS2 YEL072W PEX2 MET16 TF SWI4 (4 / 116 2.78%) transcription factor TOS10 EXG1 SKM1 YPR009W TF MET4 (4 / 28 2.78%) transcriptional activator of sulfur metabolism YAP5 YFR035C PEX2 CRR1 TF MAC1 (3 / 30 2.08%) metal binding activator YJL217W CRR1 CTR1 TF PDR1 (3 / 53 2.08%) transcription factor RPS24A UGO1 YIL175W TF RFX1 (3 / 28 2.08%) repressor of DNA damage-inducible genes RNR4 RNR3 RNR2 TF GAL4 (3 / 31 2.08%) transcription factor GAL3 YIL175W GAL2 TF SWI5 (3 / 84 2.08%) transcription factor YLR012C YML131W HOR7 TF YAP1 (3 / 40 2.08%) transcriptional activator involved in oxidative stress response YAP6 YLR460C ATR1 TF ARO80 (3 / 28 2.08%) positive transcription regulator of ARO9 and ARO10 ARO10 SPS100 YHR140W TF DAL81 (3 / 37 2.08%) transcriptional activator for allantoin and GABA catabolic genes BUD3 PEX2 YLR031W TF ABF1 (3 / 251 2.08%) ARS-binding factor MRP20 LAS21 EBP2 TF FKH2 (3 / 92 2.08%) homology to D.melanogaster forkhead protein YHL023C EXG1 MDG1 TF MBP1 (2 / 99 1.39%) "transcription factor, subunit of the MBF factor" EXG1 YNL274C TF SWI6 (2 / 84 1.39%) transcription factor YOL160W SKM1 TF YFL044C (2 / 22 1.39%) weak similarity to human dystrophin HSP30 TFB4 TF PHO4 (2 / 54 1.39%) transcription factor DAN1 YOL160W TF RME1 (2 / 16 1.39%) zinc-finger transcription factor FLO1 YOL154W TF CBF1 (2 / 38 1.39%) kinetochore protein YLL055W GAL2 TF IXR1 (2 / 33 1.39%) intrastrand crosslink recognition protein and transcription factor PET130 SDH2 TF AZF1 (2 / 7 1.39%) asparagine-rich zinc finger protein NPR2 YHL041W TF REB1 (2 / 128 1.39%) transcription factor MF(ALPHA)2 YGR243W TF HSF1 (2 / 48 1.39%) heat shock transcription factor TAD2 HOR7 * TF MSN4 (2 / 22 1.39%) transcriptional activator YIL176C YML131W TF HAP4 (2 / 57 1.39%) CCAAT-binding factor subunit YBL044W YJR078W TF BAS1 (2 / 37 1.39%) transcription factor CEM1 JEN1 TF MOT3 (2 / 17 1.39%) high-copy suppressor of MOT1-SPT3 synthetic lethality SPS2 SOR1 + 0.497854 - 0.000000 DIT1 [388] spore wall maturation protein + 0.333990 - 0.000000 SPS100 sporulation-specific wall maturation protein + 0.291953 - 0.000000 FDH1 strong similarity to H.polymorpha formate dehydrogenase + 0.272579 - 0.000000 HXT13 [302 303 750 788 897 898 1117 1251 1252 1621] high-affinity hexose transporter + 0.252187 - 0.000224 YNR071C [254 388] strong similarity to UDP-glucose 4-epimerase Gal10p + 0.187455 - 0.000000 HXT15 [302 303 750 788 897 898 1117 1251 1252 1621] strong similarity to Hxt17p and Hxt7p + 0.182516 - 0.000000 YIL172C [254] identical to Fsp2p and similarity to other alpha-glucosidases + 0.170126 - 0.000000 YLL055W [254] similarity to Dal5p + 0.161721 - 0.000000 YOL157C [254 388] strong similarity to alpha-glucosidases + 0.160817 - 0.000000 HXT16 [302 303 750 788 897 898 1117 1251 1252 1621] member of the hexose transporter family of the major facilitator superfamily [MFS] + 0.151350 - 0.000000 FSP2 [254 388] strong similarity to alpha-D-glucosidase + 0.130953 - 0.000000 HSP12 [343 1621] heat shock protein + 0.127553 - 0.000000 DAN1 only expressed under anaerobic conditions + 0.122472 - 0.000000 YJL216C [254 388] strong similarity to Mal62p + 0.122333 - 0.000000 DIT2 [388] cytochrome P450 56 + 0.120260 - 0.000000 YKR105C [254 388] strong similarity to Sge1p and hypothetical protein YCL069w + 0.106471 - 0.000000 YML131W [254] similarity to human leukotriene b4 12-hydroxydehydrogenase + 0.096656 - 0.000000 PRR2 [388] strong similarity to putative protein kinase NPR1 + 0.083721 - 0.000000 YGR243W strong similarity to hypothetical protein YHR162w + 0.083178 - 0.000000 FLO9 [289 343 377 735 736 1115 1247 2187] strong similarity to Flo1p + 0.073919 - 0.000000 YHR213W [254 388] "strong similarity to Flo5p, Flo1p, Flo9p - putative pseudogene" + 0.068355 - 0.000000 FLO1 [289 343 377 735 736 1115 1247 2187] cell wall protein involved in flocculation + 0.064608 - 0.000291 YPL275W identical to a region of YOR388c + 0.064203 - 0.000000 YIR041W [254 388] similarity to members of the Srp1p/Tip1p family + 0.063190 - 0.000000 YMR325W [254 388] strong similarity to members of the Srp1p/Tip1p family + 0.060922 - 0.000000 DDR48 heat shock protein + 0.060854 - 0.000000 YAP6 "transcription factor, of a fungal-specific family of bzip proteins" + 0.060277 - 0.000000 RNR4 ribonucleotide reductase small subunit + 0.056879 - 0.000000 YIL176C [254 388] strong similarity to members of the Srp1p/Tip1p family + 0.055841 - 0.000000 NRG1 transcriptional repressor for glucose repression of STA1 gene expression + 0.054679 - 0.000000 YJL217W [254] similarity to conserved hypothetical protein VCA0345 Vibrio cholerae + 0.054452 - 0.000000 ECM13 [388] involved in cell wall structure of biosynthesis + 0.052729 - 0.000000 PHM7 [254] similarity to A.thaliana hyp1 protein + 0.052045 - 0.000000 MSN4 transcriptional activator + 0.051733 - 0.000000 YJL218W [254 388] strong similarity to E.coli galactoside O-acetyltransferase + 0.046668 - 0.000000 TIR1 "cold-shock induced protein of the Tir1p,Tip1p family" + 0.046138 - 0.000000 RNR3 "ribonucleotide reductase, repair inducible large subunit" + 0.045383 - 0.000000 YPL276W [388] identical to a region of YOR388c + 0.044033 - 0.000176 YPL277C [254] strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.043471 - 0.000000 ISF1 [388] involved in suppression of mitochondrial splicing defect + 0.043000 - 0.000000 HXT6 [302 303 750 788 897 898 1117 1251 1252 1621] high-affinity hexose transporter + 0.038905 - 0.000000 YHR049W [254] similarity to S.pombe dihydrofolate reductase and YOR280c + 0.037935 - 0.000000 YOR338W [254 388] similarity to YAL034c + 0.036672 - 0.000000 SOR1 [388] sorbitol dehydrogenase + 0.036025 - 0.000000 YLR012C [254 388] hypothetical protein + 0.035604 - 0.000000 RNR2 "ribonucleoside-diphosphate reductase, small subunit" + 0.035566 - 0.000000 SPO73 [388] hypothetical protein + 0.035481 - 0.000000 SMP1 MADS-box transcription factor + 0.035144 - 0.000000 RTA1 [254] involved in 7-aminocholesterol resistance + 0.033974 - 0.000000 GAP1 [1621] general amino acid permease + 0.033211 - 0.000000 JEN1 [1621] carboxylic acid transporter protein + 0.032116 - 0.000000 MTH1 [302 388 897 1251] repressor of hexose transport genes + 0.031995 - 0.000000 YPL278C [254 388] strong similarity to hypothetical protein YOR389w/putative pseudogene + 0.031985 - 0.000000 GIT1 [1621] glycerophosphoinositol transporter + 0.031651 - 0.000000 YLR460C [254 388] similarity to C.carbonum toxD protein + 0.029379 - 0.000000 ICY1 [254] similarity to ICY2 + 0.029266 - 0.000000 FLO10 [289 343 377 735 736 1115 1247 2187] similarity to Flo1p + 0.029151 - 0.000000 YHR033W [254] strong similarity to glutamate 5-kinase + 0.028829 - 0.000000 PRM7 hypothetical protein + 0.028410 - 0.000000 ACA1 ATF/CREB activator + 0.028148 - 0.000000 YNL274C similarity to glycerate- and formate-dehydrogenases + 0.027931 - 0.000000 GAT4 "strong similarity to GAT3, similarity to GAT2" + 0.026206 - 0.000000 DUR3 [1621] urea transport protein + 0.025838 - 0.000000 YMR253C [254] strong similarity to YPL264c + 0.025272 - 0.000000 YHR140W [254] hypothetical protein + 0.024076 - 0.000000 USV1 [254 388] "similarity to Rgm1p, weak similarity to transcription factors" + 0.023839 - 0.000000 HSP30 [1621] heat shock protein + 0.023561 - 0.000000 YJL105W [254 388] similarity to hypothetical protein YKR029c + 0.023238 - 0.000000 NRG2 weak similarity to A.niger carbon catabolite repressor protein + 0.023080 - 0.000000 YCR102C [254 388] similarity to C.carbonum toxD gene + 0.022872 - 0.000000 YPR009W similarity to sterol uptake protein Sut1p + 0.022683 - 0.000000 YOR049C [1621] "similarity to YER185w, Rta1p" + 0.022333 - 0.000000 STL1 member of the sugar permease family + 0.022291 - 0.000000 EXG1 "exo-beta-1,3-glucanase (I/II), major isoform" + 0.000000 - 0.022129 RPS24A 40s small subunit ribosomal protein S24.e + 0.022075 - 0.000000 YOL160W hypothetical protein + 0.022018 - 0.000000 YPS5 [254 388] similarity to hypothetical aspartyl proteinase YIR039C + 0.021844 - 0.000000 YJR061W [254 388] similarity to Mnn4p + 0.021687 - 0.000000 SDH2 succinate dehydrogenase iron-sulfur protein subunit + 0.021363 - 0.000000 UBP11 [254 388] ubiquitin C-terminal hydrolase + 0.020897 - 0.000000 YPC1 Alkaline Ceramidase + 0.020477 - 0.000000 GAL2 [302 303 788 898 1252 1621] galactose (and glucose) permease + 0.020157 - 0.000000 GAL3 galactokinase + 0.020148 - 0.000000 GRE2 similarity to plant dihydroflavonol-4-reductases + 0.019845 - 0.000000 AQY2 [1621] strong similarity to AQY1 + 0.019288 - 0.000000 HXT11 [302 303 750 788 897 898 1117 1251 1252 1621] low affinity glucose transport protein + 0.019121 - 0.000000 CTR1 [1621] copper transport protein + 0.019014 - 0.000000 CEM1 "beta-keto-acyl-ACP synthase, mitochondrial" + 0.000000 - 0.018947 MF(ALPHA)2 mating pheromone alpha-2 factor + 0.018899 - 0.000000 YNR068C [254 388] similarity to Bul1p + 0.018897 - 0.000000 CYC7 cytochrome-c isoform 2 + 0.018883 - 0.000000 YIR014W [254] hypothetical protein + 0.018743 - 0.000000 YDR541C [254 388] similarity to dihydroflavonol-4-reductases + 0.018449 - 0.000000 YFR035C [254 388] hypothetical protein + 0.018328 - 0.000000 TOS10 [254 388] hypothetical protein + 0.000000 - 0.018236 ARO10 "similarity to Pdc6p, Thi3p and to pyruvate decarboxylases" + 0.018232 - 0.000000 YOL154W [254] similarity to S.fumigata Asp FII + 0.018211 - 0.000000 PUT1 proline oxidase + 0.000000 - 0.018114 LAS21 [1621] required for addition of a side chain to the glycosylphospatidylinositol (GPI) core structure + 0.018114 - 0.000000 MUC1 [343 377 1621] "extracellular alpha-1,4-glucan glucosidase" + 0.018051 - 0.000000 YER028C similarity to Mig1p + 0.018007 - 0.000000 MDG1 [1621] GTP-binding protein of the pheromone-response pathway + 0.000000 - 0.017813 PEX2 peroxisomal assembly protein - peroxin + 0.000000 - 0.017803 YOR292C [254] similarity to human and mouse glomerulosclerosis protein Mpv17 + 0.017638 - 0.000000 PET130 [254 388] "protein synthesis protein, mitochondrial" + 0.000000 - 0.017624 DTR1 dityrosine transporter + 0.000000 - 0.017406 UGO1 similarity to chromosome segregation protein Cse1p + 0.000000 - 0.017371 RRN10 RNA polymerase I-specific transcription initiation factor + 0.017327 - 0.000000 YPR013C [254 388] similarity to transcription factors + 0.017234 - 0.000000 YCR100C [254 388] "strong similarity to Pep1p, VTH1p and VTH22p" + 0.017173 - 0.000000 CIN5 transcriptional activator + 0.017164 - 0.000000 HOR7 hyperosmolarity-responsive protein + 0.017122 - 0.000000 MET16 3'-phosphoadenylylsulfate reductase + 0.017006 - 0.000000 ATR1 [1621] aminotriazole and 4-nitroquinoline resistance protein + 0.000000 - 0.016844 YEL072W [254 388] hypothetical protein + 0.016843 - 0.000000 YNL144C [254 388] similarity to YHR131c + 0.016760 - 0.000000 YDL246C [388] strong similarity to Sor1p + 0.000000 - 0.016447 SPS2 sporulation-specific protein + 0.016241 - 0.000000 BUD3 budding protein + 0.016234 - 0.000000 CRR1 [254 388] similarity to Crh1p cell wall protein + 0.016100 - 0.000000 YIL175W [254 388] strong similarity to subtelomeric encoded proteins + 0.016078 - 0.000000 PHD1 transcription factor + 0.015912 - 0.000000 YAE1 [254] similarity to S. pombe SPAC2C4.12c putative phosphotransferase + 0.000000 - 0.015887 YPL062W hypothetical protein + 0.000000 - 0.015858 KAR5 nuclear fusion protein + 0.015779 - 0.000000 SKM1 [388] Ste20/PAK-like protein kinase + 0.000505 - 0.015675 YAP5 involved in transcription activation + 0.015662 - 0.000000 YJR078W "similarity to mammalian indoleamine 2,3-dioxygenase" + 0.015610 - 0.000723 SPH1 required for bipolar bud site selection + 0.015596 - 0.000000 YLR031W [254 388] similarity to hypothetical protein YMR124w + 0.000000 - 0.015592 NPR2 [388] nitrogen permease regulator + 0.015582 - 0.000000 TFB4 component of RNA polymerase transcription initiation TFIIH factor + 0.015582 - 0.000656 TAD2 tRNA-specific adenosine deaminase 2 + 0.015578 - 0.000000 YHL041W weak similarity to Drosophila hypothetical protein 6 + 0.015576 - 0.000000 YGR035C [254 388] hypothetical protein + 0.000308 - 0.015546 ORC1 "origin recognition complex, 104 KD subunit" + 0.000000 - 0.015545 MSS18 splicing protein + 0.000000 - 0.015543 YBL044W [254 388] hypothetical protein + 0.000390 - 0.015539 LEU3 transcription factor + 0.015510 - 0.000000 YHL023C [254 388] weak similarity to TRCDSEMBL:SPBC543_4 hypothetical protein S.pombe + 0.015510 - 0.001069 YLR428C questionable ORF + 0.015488 - 0.000282 MRP20 "ribosomal protein of the large subunit, mitochondrial" + 0.000953 - 0.015467 EBP2 required for pre-rRNA processing and ribosomal subunit assembly + 0.015462 - 0.000000 RIM9 [388] regulator for sporulation and invasive growth Cluster 4: 28 genes TF FHL1 (6 / 166 21.43%) transcriptional activator of the forkhead/hnf3 family RPL27B RPS26A RPL17B RPS21A TEF1 PRE2 TF ABF1 (5 / 251 17.86%) ARS-binding factor UBR2 FIN1 NUP57 GCN5 SCD6 TF SKN7 (3 / 83 10.71%) transcription factor with similarity to Hsf1p HOM2 FKS3 YMR304C-A TF REB1 (3 / 128 10.71%) transcription factor HOM2 NAT2 VPS13 TF PDR1 (2 / 53 7.14%) transcription factor FIG1 RPL27B TF SWI4 (2 / 116 7.14%) transcription factor FKS3 YMR304C-A TF SWI5 (2 / 84 7.14%) transcription factor YEL077C YLR012C TF NRG1 (2 / 68 7.14%) transcriptional repressor for glucose repression of STA1 gene expression YAL064W YLR012C + 0.281117 - 0.000000 FIN1 weak similarity to sea urchin myosin heavy chain + 0.280986 - 0.000000 TEF1 "translation elongation factor eEF1 alpha-A chain, cytosolic" + 0.280795 - 0.000000 FIG1 required for efficient mating + 0.280670 - 0.000106 VPS13 involved in regulating membrane traffic + 0.277828 - 0.000000 ALG7 UDP-N-acetylglucosamine-1-phosphate transferase + 0.263639 - 0.000412 GCN5 histone acetyltransferase + 0.263445 - 0.000000 RPL17B 60s large subunit ribosomal protein L17.e + 0.263286 - 0.000078 FKS3 "similarity to 1,3-beta-glucan synthases" + 0.263246 - 0.000106 YBL044W hypothetical protein + 0.263244 - 0.000000 VAM3 syntaxin (t-SNARE) + 0.263038 - 0.000418 UBR2 similarity to ubiquitin--protein ligase Ubr1p + 0.262627 - 0.000096 DCI1 "Enoyl-CoA Hydratase, peroxisomal" + 0.240923 - 0.000044 YLR012C hypothetical protein + 0.194477 - 0.000000 YAL064W hypothetical protein + 0.085702 - 0.000415 NUP57 nuclear pore protein + 0.078970 - 0.000000 YEL018W weak similarity to Rad50p + 0.055211 - 0.000000 ZRC1 zinc- and cadmium resistance protein + 0.042529 - 0.000000 RPS21A ribosomal protein S21.e + 0.000000 - 0.037395 YMR082C hypothetical protein + 0.035331 - 0.000000 SCD6 suppressor of clathrin deficiency + 0.027042 - 0.000000 YMR304C-A questionable ORF + 0.026243 - 0.000230 PRE2 20S proteasome subunit (beta5) + 0.021982 - 0.000000 YLR243W strong similarity to YOR262w + 0.000000 - 0.018735 RPL27B 60S large subunit ribosomal protein + 0.018519 - 0.000000 YEL077C strong similarity to subtelomeric encoded proteins + 0.017214 - 0.000163 HOM2 aspartate-semialdehyde dehydrogenase + 0.016976 - 0.000000 RPS26A 40S small subunit ribosomal protein S26e.c7 + 0.015447 - 0.000147 NAT2 N-acetyltransferase for N-terminal methionine Cluster 7: 24 genes TF ABF1 (4 / 251 16.67%) ARS-binding factor TOM6 SEC18 YKR029C RPB10 TF PDR1 (3 / 53 12.50%) transcription factor YBL112C NOP14 YDR543C TF SKN7 (3 / 83 12.50%) transcription factor with similarity to Hsf1p SOK2 KNS1 AFG2 TF HSF1 (3 / 48 12.50%) heat shock transcription factor REB1 YGR198W BUD7 TF YAP5 (3 / 81 12.50%) involved in transcription activation YBL112C EXO84 YDR543C TF RGM1 (2 / 21 8.33%) transcriptional repressor protein YBL112C YDR543C TF GAL4 (2 / 31 8.33%) transcription factor YBL112C YDR543C TF CIN5 (2 / 129 8.33%) transcriptional activator YMR244C-A YOL157C TF SWI4 (2 / 116 8.33%) transcription factor SOK2 TOS6 TF SWI5 (2 / 84 8.33%) transcription factor YDR543C YLR346C TF IME4 (2 / 33 8.33%) positive transcription factor for IME2 EXO84 YLR346C TF HAP4 (2 / 57 8.33%) CCAAT-binding factor subunit YDR543C COX12 + 0.000000 - 0.231085 EXO84 exocyst protein essential for secretion + 0.000000 - 0.230960 NOP14 nuclear and nucleolar protein with possible role in ribosome biogenesis + 0.230789 - 0.000000 SEC18 "vesicular-fusion protein, functional homolog of NSF" + 0.230727 - 0.000000 TOM6 "mitochondrial outer membrane import receptor subunit, 6 kD" + 0.000000 - 0.230135 YDR543C strong similarity to subtelomeric encoded proteins + 0.228241 - 0.000000 AFG2 strong similarity to CDC48 + 0.227083 - 0.000000 SEO1 suppressor of sulfoxyde ethionine resistance + 0.226269 - 0.000426 YKR029C similarity to YJL105w and Lentinula MFBA protein + 0.000335 - 0.225741 RPB10 "DNA-directed polymerase I, II, III 8.3 subunit" + 0.225615 - 0.000179 YGR198W weak similarity to PIR:T38996 hypothetical protein SPAC637.04 S. pombe + 0.225393 - 0.000000 YNL043C questionable ORF + 0.225312 - 0.000091 MLH2 "similarity to human mutL protein homolog, mouse PMS2, Mlh1p and Pms1p" + 0.224679 - 0.000164 TOS6 similarity to Mid2p + 0.223856 - 0.000000 YOL157C strong similarity to alpha-glucosidases + 0.209426 - 0.000000 YBL112C strong similarity to subtelomeric encoded proteins + 0.201805 - 0.000000 YLR346C weak similarity to YGR035c + 0.201761 - 0.000000 KNS1 ser/thr protein kinase + 0.197451 - 0.000180 BUD7 involved in bud-site selection + 0.197430 - 0.000157 COX12 "cytochrome-c oxidase, subunit VIB" + 0.197338 - 0.000072 TRF4 topoisomerase I-related protein + 0.136313 - 0.000000 SOK2 regulatory protein in the PKA signal transduction pathway + 0.109724 - 0.000186 REB1 transcription factor + 0.028968 - 0.000000 TDH2 glyceraldehyde-3-phosphate dehydrogenase 2 + 0.024547 - 0.000000 YMR244C-A questionable ORF Cluster 9: 10 genes TF SKN7 (2 / 83 20.00%) transcription factor with similarity to Hsf1p YLR111W YOL154W TF ARG81 (2 / 21 20.00%) transcription factor involved in arginine metabolism YDR042C FYV11 + 0.995218 - 0.000367 YDR010C hypothetical protein + 0.000744 - 0.028888 YLR111W hypothetical protein + 0.019505 - 0.015450 YOL154W similarity to S.fumigata Asp FII + 0.018344 - 0.000000 YDR042C hypothetical protein + 0.000867 - 0.017906 TRL1 tRNA ligase + 0.000000 - 0.017903 YBL113C similarity to Y' ORFs + 0.000402 - 0.017652 FYV11 similarity to repeat structures in a Plasmodium falciparum protein (MESA) that binds human erythrocyte protein 4.1. + 0.017647 - 0.000000 YML089C questionable ORF + 0.016714 - 0.000000 YLR364W weak similarity to GRX2 Homo sapiens glutaredoxin 2 + 0.000000 - 0.016212 HSP12 heat shock protein Cluster 11: 41 genes * TF SWI4 (6 / 116 14.63%) transcription factor SWI4 HTB1 YGR050C YGR151C TYE7 YMR304C-A TF FHL1 (5 / 166 12.20%) transcriptional activator of the forkhead/hnf3 family RPL21A RPS26A RPL17B RPS21A TEF1 TF ABF1 (4 / 251 9.76%) ARS-binding factor CNB1 UBR2 FIN1 SWI3 TF FKH2 (3 / 92 7.32%) homology to D.melanogaster forkhead protein YGL007W ADH4 YGR050C TF PHD1 (2 / 74 4.88%) transcription factor YBR159W YHR213W TF SWI6 (2 / 84 4.88%) transcription factor SWI4 YOL160W TF STP2 (2 / 11 4.88%) involved in pre-tRNA splicing FIG1 YDR215C TF SKN7 (2 / 83 4.88%) transcription factor with similarity to Hsf1p MUC1 YMR304C-A TF IXR1 (2 / 33 4.88%) intrastrand crosslink recognition protein and transcription factor HST3 YAL064W TF CIN5 (2 / 129 4.88%) transcriptional activator YDR504C YMR082C TF SWI5 (2 / 84 4.88%) transcription factor YEL077C YLR012C TF REB1 (2 / 128 4.88%) transcription factor BPH1 VPS13 TF NRG1 (2 / 68 4.88%) transcriptional repressor for glucose repression of STA1 gene expression YAL064W YLR012C TF YAP6 (2 / 75 4.88%) "transcription factor, of a fungal-specific family of bzip proteins" MUC1 DCI1 TF YAP5 (2 / 81 4.88%) involved in transcription activation YDR370C TEF1 TF NDD1 (2 / 82 4.88%) protein required for nuclear division HST3 YGL007W + 0.000466 - 0.174325 SWI4 transcription factor + 0.000376 - 0.174303 YMR304C-A questionable ORF + 0.000000 - 0.174222 HTB1 histone H2B + 0.000435 - 0.174218 YGR151C questionable ORF + 0.174111 - 0.000335 SWI3 transcription regulatory protein + 0.000000 - 0.174108 FIN1 weak similarity to sea urchin myosin heavy chain + 0.000000 - 0.174106 TEF1 "translation elongation factor eEF1 alpha-A chain, cytosolic" + 0.000000 - 0.174091 RPS26A 40S small subunit ribosomal protein S26e.c7 + 0.000000 - 0.174089 RPL17B 60s large subunit ribosomal protein L17.e + 0.000599 - 0.174060 YGR050C questionable ORF + 0.173999 - 0.000354 CNB1 "calcineurin B, regulatory subunit" + 0.000000 - 0.173991 ADH4 alcohol dehydrogenase IV + 0.000000 - 0.173964 RPS21A ribosomal protein S21.e + 0.173921 - 0.000000 YMR082C hypothetical protein + 0.000000 - 0.173917 YDR504C similarity to hypothetical T.brucei protein + 0.173882 - 0.000264 TYE7 basic helix-loop-helix transcription factor + 0.000000 - 0.173859 BPH1 similarity to human beige-like protein and mouse lysosomal trafficking regulator + 0.000000 - 0.173849 YDR215C hypothetical protein + 0.000000 - 0.173849 YEL077C strong similarity to subtelomeric encoded proteins + 0.000195 - 0.173837 HST3 silencing protein + 0.000000 - 0.173834 ATP20 subunit G of the dimeric form of mitochondrial F1F0-ATP Synthase + 0.173814 - 0.000331 YGL007W questionable ORF + 0.000060 - 0.173756 PUT1 proline oxidase + 0.173705 - 0.000067 YIL127C weak similarity to Smy2p + 0.000000 - 0.173663 MUC1 "extracellular alpha-1,4-glucan glucosidase" + 0.000000 - 0.173553 ALG7 UDP-N-acetylglucosamine-1-phosphate transferase + 0.000050 - 0.173481 VIP1 strong similarity to S. pombe protein Asp1p + 0.000145 - 0.173435 YOL160W hypothetical protein + 0.171473 - 0.000063 MSS18 splicing protein + 0.000000 - 0.171338 YAL064W hypothetical protein + 0.170632 - 0.000346 UBR2 similarity to ubiquitin--protein ligase Ubr1p + 0.170439 - 0.000154 DCI1 "Enoyl-CoA Hydratase, peroxisomal" + 0.000000 - 0.148620 FIG1 required for efficient mating + 0.000000 - 0.079706 TNA1 similarity to allantoate transport protein + 0.000000 - 0.047759 YHR213W "strong similarity to Flo5p, Flo1p, Flo9p - putative pseudogene" + 0.000000 - 0.036559 YLR243W strong similarity to YOR262w + 0.025104 - 0.000075 VPS13 involved in regulating membrane traffic + 0.000041 - 0.024670 YBR159W similarity to human 17-beta-hydroxysteroid dehydrogenase + 0.000000 - 0.023534 YLR012C hypothetical protein + 0.000296 - 0.018918 RPL21A ribosomal protein L21.e + 0.000068 - 0.015677 YDR370C hypothetical protein Cluster 15: 7 genes TF NDD1 (2 / 82 28.57%) protein required for nuclear division SPO12 YOR024W + 0.711530 - 0.000000 YOR024W hypothetical protein + 0.497180 - 0.000138 YNL017C hypothetical protein + 0.001047 - 0.488154 DAN1 only expressed under anaerobic conditions + 0.000440 - 0.047500 YCR105W strong similarity to alcohol dehydrogenases + 0.042063 - 0.000001 SPO12 sporulation protein + 0.032572 - 0.000000 FUS1 cell fusion protein + 0.000000 - 0.020950 YIL102C strong similarity to YIL014c-a Cluster 16: 5 genes + 0.000000 - 0.680715 YOR024W hypothetical protein + 0.678707 - 0.000201 YLR364W weak similarity to GRX2 Homo sapiens glutaredoxin 2 + 0.000118 - 0.258259 YKL118W questionable ORF + 0.000000 - 0.039961 CLB6 "cyclin, B-type" + 0.000000 - 0.027386 ZRT1 high-affinity zinc transport protein Cluster 17: 5 genes + 0.985141 - 0.000539 YGL182C questionable ORF + 0.091214 - 0.000285 YLR465C questionable ORF + 0.090923 - 0.000203 TFA1 "TFIIE subunit (transcription initiation factor), 66 kD" + 0.071551 - 0.000003 HAP5 CCAAT-binding factor subunit + 0.020472 - 0.000128 YKL151C similarity to C.elegans hypothetical protein R107.2 Cluster 18: 42 genes TF ABF1 (7 / 251 16.67%) ARS-binding factor UBR2 SLA1 NHP2 NUP57 GCN5 IQG1 SCD6 TF PHD1 (3 / 74 7.14%) transcription factor YBR159W YGR251W YHR213W TF SWI4 (3 / 116 7.14%) transcription factor HTB1 BMH1 FKS3 TF YAP6 (3 / 75 7.14%) "transcription factor, of a fungal-specific family of bzip proteins" MUC1 YNR067C DCI1 TF HAP4 (3 / 57 7.14%) CCAAT-binding factor subunit YBL044W YLR171W YML089C TF FHL1 (3 / 166 7.14%) transcriptional activator of the forkhead/hnf3 family RPL27B RPL17B RPS21A TF SWI6 (2 / 84 4.76%) transcription factor YGR110W VAM3 TF PDR1 (2 / 53 4.76%) transcription factor FIG1 RPL27B TF STP2 (2 / 11 4.76%) involved in pre-tRNA splicing FIG1 YDR215C TF SKN7 (2 / 83 4.76%) transcription factor with similarity to Hsf1p MUC1 FKS3 TF CIN5 (2 / 129 4.76%) transcriptional activator YDR504C YMR082C TF HIR1 (2 / 27 4.76%) histone transcription regulator HTB1 GEA2 TF NRG1 (2 / 68 4.76%) transcriptional repressor for glucose repression of STA1 gene expression YAL064W YLR012C TF FKH2 (2 / 92 4.76%) homology to D.melanogaster forkhead protein KGD2 ADH4 TF NDD1 (2 / 82 4.76%) protein required for nuclear division KGD2 IQG1 + 0.205627 - 0.000000 ADH4 alcohol dehydrogenase IV + 0.202328 - 0.000000 VAM3 syntaxin (t-SNARE) + 0.202166 - 0.000000 RPL17B 60s large subunit ribosomal protein L17.e + 0.202158 - 0.000000 YBL044W hypothetical protein + 0.202124 - 0.000000 FKS3 "similarity to 1,3-beta-glucan synthases" + 0.201896 - 0.000000 KGD2 2-oxoglutarate dehydrogenase complex E2 component + 0.201719 - 0.000000 GCN5 histone acetyltransferase + 0.197759 - 0.000000 DCI1 "Enoyl-CoA Hydratase, peroxisomal" + 0.197160 - 0.000000 UBR2 similarity to ubiquitin--protein ligase Ubr1p + 0.194461 - 0.000000 YLR012C hypothetical protein + 0.192276 - 0.000000 NUP57 nuclear pore protein + 0.190569 - 0.000000 RPS21A ribosomal protein S21.e + 0.189651 - 0.000000 MSS18 splicing protein + 0.183236 - 0.000000 HTB1 histone H2B + 0.000000 - 0.174912 YAP5 involved in transcription activation + 0.173769 - 0.000000 GEA2 GDP/GTP exchange factor for ARF + 0.173478 - 0.000000 YAL064W hypothetical protein + 0.000000 - 0.173067 YGR273C similarity to hypothetical protein YMR295c + 0.172044 - 0.000000 RPL27B 60S large subunit ribosomal protein + 0.172026 - 0.000000 YDR215C hypothetical protein + 0.000000 - 0.172001 SCD6 suppressor of clathrin deficiency + 0.171954 - 0.000000 BMH1 14-3-3 protein involved in rapamycin-sensitive signalling + 0.171943 - 0.000000 SLA1 cytoskeleton assembly control protein + 0.171850 - 0.000000 MUC1 "extracellular alpha-1,4-glucan glucosidase" + 0.171300 - 0.000000 YGR251W hypothetical protein + 0.171161 - 0.000000 YGR110W weak similarity to YLR099c and YDR125c + 0.000000 - 0.170980 YBR159W similarity to human 17-beta-hydroxysteroid dehydrogenase + 0.000000 - 0.150859 YML089C questionable ORF + 0.000000 - 0.149431 FIG1 required for efficient mating + 0.075374 - 0.000000 YNR067C similarity to beta-glucan-elicitor receptor - Glycine max + 0.070485 - 0.000000 CLB4 "cyclin, G2/M-specific" + 0.044395 - 0.000000 YDR504C similarity to hypothetical T.brucei protein + 0.042723 - 0.000000 ALG7 UDP-N-acetylglucosamine-1-phosphate transferase + 0.038550 - 0.000000 ZRC1 zinc- and cadmium resistance protein + 0.032843 - 0.000000 YHR213W "strong similarity to Flo5p, Flo1p, Flo9p - putative pseudogene" + 0.029967 - 0.000000 IQG1 "involved in cytokinesis, has similarity to mammalian IQGAP proteins" + 0.028182 - 0.000000 BPH1 similarity to human beige-like protein and mouse lysosomal trafficking regulator + 0.026418 - 0.000000 NHP2 nucleolar rRNA processing protein + 0.000000 - 0.023059 YMR082C hypothetical protein + 0.000000 - 0.019093 TNA1 similarity to allantoate transport protein + 0.017189 - 0.000000 YLR171W questionable ORF + 0.000000 - 0.016404 VIP1 strong similarity to S. pombe protein Asp1p Cluster 19: 42 genes TF ABF1 (7 / 251 16.67%) ARS-binding factor UBR2 SLA1 NHP2 NUP57 GCN5 IQG1 SCD6 TF PHD1 (3 / 74 7.14%) transcription factor YBR159W YGR251W YHR213W TF SWI4 (3 / 116 7.14%) transcription factor HTB1 BMH1 FKS3 TF YAP6 (3 / 75 7.14%) "transcription factor, of a fungal-specific family of bzip proteins" MUC1 YNR067C DCI1 TF HAP4 (3 / 57 7.14%) CCAAT-binding factor subunit YBL044W YLR171W YML089C TF FKH2 (3 / 92 7.14%) homology to D.melanogaster forkhead protein KGD2 YGL007W ADH4 TF NDD1 (3 / 82 7.14%) protein required for nuclear division KGD2 YGL007W IQG1 TF FHL1 (3 / 166 7.14%) transcriptional activator of the forkhead/hnf3 family RPL27B RPL17B RPS21A TF MBP1 (2 / 99 4.76%) "transcription factor, subunit of the MBF factor" YGR110W TOF1 TF SWI6 (2 / 84 4.76%) transcription factor YGR110W VAM3 TF PDR1 (2 / 53 4.76%) transcription factor FIG1 RPL27B TF STP2 (2 / 11 4.76%) involved in pre-tRNA splicing FIG1 YDR215C TF SKN7 (2 / 83 4.76%) transcription factor with similarity to Hsf1p MUC1 FKS3 TF HIR1 (2 / 27 4.76%) histone transcription regulator HTB1 GEA2 TF NRG1 (2 / 68 4.76%) transcriptional repressor for glucose repression of STA1 gene expression YAL064W YLR012C TF ACE2 (2 / 64 4.76%) metallothionein expression activator BMH1 YGL007W + 0.000000 - 0.215310 YML089C questionable ORF + 0.000178 - 0.202433 YBR159W similarity to human 17-beta-hydroxysteroid dehydrogenase + 0.202318 - 0.000164 YGR251W hypothetical protein + 0.201912 - 0.000000 MUC1 "extracellular alpha-1,4-glucan glucosidase" + 0.201909 - 0.000004 YGR110W weak similarity to YLR099c and YDR125c + 0.000000 - 0.201875 SCD6 suppressor of clathrin deficiency + 0.201811 - 0.000102 SLA1 cytoskeleton assembly control protein + 0.201742 - 0.000215 BMH1 14-3-3 protein involved in rapamycin-sensitive signalling + 0.201708 - 0.000000 RPL27B 60S large subunit ribosomal protein + 0.201552 - 0.000000 YDR215C hypothetical protein + 0.000000 - 0.200694 YGR273C similarity to hypothetical protein YMR295c + 0.199982 - 0.000114 GEA2 GDP/GTP exchange factor for ARF + 0.000000 - 0.199605 FIG1 required for efficient mating + 0.000034 - 0.198990 YAP5 involved in transcription activation + 0.191756 - 0.000000 HTB1 histone H2B + 0.184587 - 0.000000 MSS18 splicing protein + 0.181719 - 0.000000 RPS21A ribosomal protein S21.e + 0.177009 - 0.000380 NUP57 nuclear pore protein + 0.174443 - 0.000098 KGD2 2-oxoglutarate dehydrogenase complex E2 component + 0.171047 - 0.000000 ADH4 alcohol dehydrogenase IV + 0.157460 - 0.000398 UBR2 similarity to ubiquitin--protein ligase Ubr1p + 0.156666 - 0.000164 DCI1 "Enoyl-CoA Hydratase, peroxisomal" + 0.154473 - 0.000401 GCN5 histone acetyltransferase + 0.153842 - 0.000000 RPL17B 60s large subunit ribosomal protein L17.e + 0.153801 - 0.000000 YBL044W hypothetical protein + 0.153642 - 0.000274 FKS3 "similarity to 1,3-beta-glucan synthases" + 0.153631 - 0.000096 VAM3 syntaxin (t-SNARE) + 0.147612 - 0.000000 YLR012C hypothetical protein + 0.134905 - 0.000000 YAL064W hypothetical protein + 0.089241 - 0.000000 YNR067C similarity to beta-glucan-elicitor receptor - Glycine max + 0.067379 - 0.000000 CLB4 "cyclin, G2/M-specific" + 0.044395 - 0.000000 YDR504C similarity to hypothetical T.brucei protein + 0.033296 - 0.000000 BPH1 similarity to human beige-like protein and mouse lysosomal trafficking regulator + 0.031758 - 0.000000 YHR213W "strong similarity to Flo5p, Flo1p, Flo9p - putative pseudogene" + 0.031699 - 0.000335 NHP2 nucleolar rRNA processing protein + 0.000000 - 0.029027 VIP1 strong similarity to S. pombe protein Asp1p + 0.028807 - 0.000475 IQG1 "involved in cytokinesis, has similarity to mammalian IQGAP proteins" + 0.028194 - 0.000000 ZRC1 zinc- and cadmium resistance protein + 0.000000 - 0.026928 TNA1 similarity to allantoate transport protein + 0.024685 - 0.000220 YGL007W questionable ORF + 0.018036 - 0.000087 TOF1 topoisomerase I interacting factor 1 + 0.017004 - 0.000088 YLR171W questionable ORF Cluster 20: 6 genes TF REB1 (2 / 128 33.33%) transcription factor SMP3 SEC23 TF YAP6 (2 / 75 33.33%) "transcription factor, of a fungal-specific family of bzip proteins" RPI1 YIR035C + 0.498186 - 0.000627 RPI1 negative regulator of ras-cAMP pathway + 0.498147 - 0.000461 YIR035C similarity to human corticosteroid 11-beta-dehydrogenase + 0.497995 - 0.000374 MKT1 required for propagation of M2 dsRNA satellite of L-A virus + 0.497882 - 0.000317 SMP3 protein kinase C pathway protein + 0.037440 - 0.000103 LYS9 "saccharopine dehydrogenase (NADP+, L-glutamate forming)" + 0.032224 - 0.000289 SEC23 component of COPII coat of ER-golgi vesicles Cluster 21: 4 genes + 0.000194 - 0.575899 FAT2 "AMP-binding protein, peroxisomal" + 0.575742 - 0.000216 YEL015W weak similarity to Spa2p + 0.575695 - 0.000000 IKI1 confers sensitivity to killer toxin + 0.000000 - 0.058355 NOP16 weak similarity to chicken microfibril-associated protein Cluster 22: 7 genes TF SUM1 (2 / 48 28.57%) suppressor of SIR mutations YFL040W YLR343W + 0.000000 - 0.775327 BRN1 functional homologue of human BRRN1 + 0.000000 - 0.454002 CAT8 transcription factor involved in gluconeogenesis + 0.000000 - 0.433705 YFL040W similarity to yeast glucose transport proteins + 0.000000 - 0.035014 ZRT1 high-affinity zinc transport protein + 0.018336 - 0.000120 YLR343W strong similarity to Gas1p and C.albicans pH responsive protein + 0.017085 - 0.000500 SRL3 similarity to YOR083w + 0.015456 - 0.000000 YPS3 GPI-anchored aspartyl protease 3 (yapsin 3) Cluster 26: 13 genes * TF YAP6 (4 / 75 30.77%) "transcription factor, of a fungal-specific family of bzip proteins" YAP6 AQY2 GAT4 SOR1 TF NRG1 (3 / 68 23.08%) transcriptional repressor for glucose repression of STA1 gene expression YAP6 GAT4 SOR1 TF CIN5 (2 / 129 15.38%) transcriptional activator YAP6 AQY2 TF SUM1 (2 / 48 15.38%) suppressor of SIR mutations STE3 YOR314W TF SOK2 (2 / 11 15.38%) regulatory protein in the PKA signal transduction pathway YAP6 SOR1 TF CUP9 (2 / 16 15.38%) involved in copper homeostasis repression of protein import YAP6 SOR1 TF ROX1 (2 / 23 15.38%) heme-dependent transcriptional repressor of hypoxic genes YAP6 SOR1 TF FHL1 (2 / 166 15.38%) transcriptional activator of the forkhead/hnf3 family YBR116C FYV12 + 0.000268 - 0.304728 YOR314W hypothetical protein + 0.304521 - 0.000000 FUS1 cell fusion protein + 0.000237 - 0.304094 FYV12 hypothetical protein + 0.000000 - 0.304078 STE3 pheromone a-factor receptor + 0.000228 - 0.304062 YBR116C questionable ORF + 0.000392 - 0.303704 SOR1 sorbitol dehydrogenase + 0.299716 - 0.000105 YGR110W weak similarity to YLR099c and YDR125c + 0.000000 - 0.284011 YOR024W hypothetical protein + 0.280615 - 0.000000 YOR338W similarity to YAL034c + 0.000000 - 0.268058 SEO1 suppressor of sulfoxyde ethionine resistance + 0.265205 - 0.000217 GAT4 "strong similarity to GAT3, similarity to GAT2" + 0.000000 - 0.181421 YAP6 "transcription factor, of a fungal-specific family of bzip proteins" + 0.136856 - 0.000197 AQY2 strong similarity to AQY1 Cluster 28: 14 genes * TF SWI6 (2 / 84 14.29%) transcription factor TOS6 UFE1 TF SWI5 (2 / 84 14.29%) transcription factor GPR1 PIR3 TF NRG1 (2 / 68 14.29%) transcriptional repressor for glucose repression of STA1 gene expression YAL064W ACA1 TF YAP6 (2 / 75 14.29%) "transcription factor, of a fungal-specific family of bzip proteins" ACA1 YOR029W TF HSF1 (2 / 48 14.29%) heat shock transcription factor YDR010C TAH11 + 0.000000 - 0.983874 YDR010C hypothetical protein + 0.104365 - 0.000000 RPL7B 60S large subunit ribosomal protein + 0.000000 - 0.066280 YOR314W hypothetical protein + 0.063908 - 0.000941 YAL064W hypothetical protein + 0.000000 - 0.040874 TAH11 weak similarity to Xenopus vimentin 4 + 0.038710 - 0.000000 YOR029W hypothetical protein + 0.000000 - 0.029337 YMR258C hypothetical protein + 0.026954 - 0.000000 PIR3 member of the Pir1p/Pir2p/Pir3p family + 0.025437 - 0.000149 ACA1 ATF/CREB activator + 0.000370 - 0.018328 SWI6 transcription factor + 0.000000 - 0.017967 TOS6 similarity to Mid2p + 0.000000 - 0.016791 YAP5 involved in transcription activation + 0.016746 - 0.000000 UFE1 syntaxin (T-SNARE) of the ER + 0.016548 - 0.000000 GPR1 G-protein coupled receptor Cluster 29: 15 genes TF MBP1 (2 / 99 13.33%) "transcription factor, subunit of the MBF factor" SPO12 ELO1 TF MCM1 (2 / 73 13.33%) transcription factor of the MADS box family SPO12 ELO1 TF SWI4 (2 / 116 13.33%) transcription factor ERG3 ELO1 TF ABF1 (2 / 251 13.33%) ARS-binding factor ERG3 SLA1 TF FKH2 (2 / 92 13.33%) homology to D.melanogaster forkhead protein SPO12 YJR110W + 0.000658 - 0.568116 SPO12 sporulation protein + 0.567885 - 0.000641 YJR110W similarity to human myotubularin + 0.567505 - 0.000000 PDR1 transcription factor + 0.107382 - 0.000162 SLA1 cytoskeleton assembly control protein + 0.063660 - 0.000000 HAL9 transcriptional activator of ENA1 + 0.000000 - 0.029498 ZRT1 high-affinity zinc transport protein + 0.025017 - 0.000000 YIL176C strong similarity to members of the Srp1p/Tip1p family + 0.000415 - 0.022332 ELO1 fatty acid elongation protein + 0.019209 - 0.000150 RTA1 involved in 7-aminocholesterol resistance + 0.018742 - 0.000000 PRM7 hypothetical protein + 0.017298 - 0.000000 YPS3 GPI-anchored aspartyl protease 3 (yapsin 3) + 0.016553 - 0.000000 YLR194C hypothetical protein + 0.016232 - 0.000000 DAN1 only expressed under anaerobic conditions + 0.000000 - 0.016214 CHO1 CDP-diacylglycerol serine O-phosphatidyltransferase + 0.016041 - 0.000333 ERG3 C-5 sterol desaturase Cluster 30: 5 genes + 0.978438 - 0.000447 YPL080C hypothetical protein + 0.000000 - 0.174444 YOR024W hypothetical protein + 0.072272 - 0.000000 YGR268C weak similarity to S.pombe hypothetical protein SPAC17A5 + 0.000977 - 0.039734 YHR130C weak similarity to T.brucei H+-transporting ATP synthase + 0.035234 - 0.000054 YLR031W similarity to hypothetical protein YMR124w Cluster 31: 42 genes TF ABF1 (4 / 251 9.52%) ARS-binding factor YAL053W NUP170 YCR001W YKL005C TF PHD1 (3 / 74 7.14%) transcription factor YIL175W SOR1 YKL063C TF PDR1 (3 / 53 7.14%) transcription factor YIL175W BUD19 SIN4 TF CIN5 (3 / 129 7.14%) transcriptional activator YDL129W PRO1 STD1 TF YAP6 (3 / 75 7.14%) "transcription factor, of a fungal-specific family of bzip proteins" MUC1 SOR1 YNR067C TF MBP1 (2 / 99 4.76%) "transcription factor, subunit of the MBF factor" GIN4 IRR1 TF SWI6 (2 / 84 4.76%) transcription factor GIN4 IRR1 TF SKN7 (2 / 83 4.76%) transcription factor with similarity to Hsf1p CLB1 MUC1 TF MCM1 (2 / 73 4.76%) transcription factor of the MADS box family GIN4 RAX2 TF GAL4 (2 / 31 4.76%) transcription factor YCR106W YIL175W TF SWI4 (2 / 116 4.76%) transcription factor GIN4 RAX2 TF SWI5 (2 / 84 4.76%) transcription factor PRY3 YNL269W TF REB1 (2 / 128 4.76%) transcription factor RRN6 YPR053C TF SMP1 (2 / 55 4.76%) MADS-box transcription factor YIL175W SIN4 TF NRG1 (2 / 68 4.76%) transcriptional repressor for glucose repression of STA1 gene expression SNO3 SOR1 TF IME4 (2 / 33 4.76%) positive transcription factor for IME2 SNO3 YNL269W TF YAP5 (2 / 81 4.76%) involved in transcription activation YIL175W BUD19 TF MOT3 (2 / 17 4.76%) high-copy suppressor of MOT1-SPT3 synthetic lethality SOR1 MLH2 TF MET4 (2 / 28 4.76%) transcriptional activator of sulfur metabolism ERG25 PRY3 TF FHL1 (2 / 166 4.76%) transcriptional activator of the forkhead/hnf3 family YOL128C YPL080C + 0.216441 - 0.000356 PRO1 glutamate 5-kinase + 0.000371 - 0.216434 YDL129W hypothetical protein + 0.000357 - 0.216434 STD1 dosage-dependent modulator of glucose repression + 0.000270 - 0.216379 YPL080C hypothetical protein + 0.216355 - 0.000282 YOL128C strong similarity to protein kinase Mck1p + 0.216312 - 0.000255 RAX2 weak similarity to Pst1p + 0.000264 - 0.216293 YCR001W weak similarity to chloride channel proteins + 0.000155 - 0.216256 CLB1 "cyclin, G2/M-specific" + 0.000183 - 0.216253 IRR1 essential protein + 0.000177 - 0.216240 YKL063C weak similarity to mammalian microtubule-associated protein MAP 1B + 0.000099 - 0.216235 YCR106W similarity to transcription factor + 0.216196 - 0.000117 PRP3 essential splicing factor + 0.216194 - 0.000096 DPH2 diphtheria toxin resistance protein + 0.000106 - 0.216186 HHF1 histone H4 + 0.000120 - 0.216184 YSW1 spore-specific protein + 0.000116 - 0.216163 HXT5 member of the hexose transporter family + 0.216156 - 0.000000 YIR040C strong similarity to subtelomeric encoded proteins + 0.000085 - 0.216152 YBR262C questionable ORF + 0.000000 - 0.216150 YLR364W weak similarity to GRX2 Homo sapiens glutaredoxin 2 + 0.215039 - 0.000112 MLH2 "similarity to human mutL protein homolog, mouse PMS2, Mlh1p and Pms1p" + 0.160272 - 0.000286 YKL005C weak similarity to YKR029c and D.melanogaster transcription elongation factor DmS-II + 0.000098 - 0.105325 SIN4 global regulator protein + 0.000000 - 0.058366 SNO3 strong similarity to SNO1 and SNO2 + 0.000027 - 0.053775 YDR541C similarity to dihydroflavonol-4-reductases + 0.000367 - 0.050263 SOR1 sorbitol dehydrogenase + 0.040582 - 0.000022 MDS3 negative regulator of early meiotic expression + 0.037454 - 0.000000 SIP4 interacts with SNF1 protein kinase + 0.000029 - 0.034725 PHM6 "hypothetical protein, has a role in phosphate metabolism" + 0.031310 - 0.000071 RRN6 RNA polymerase I specific transcription initiation factor + 0.000387 - 0.030578 YIL175W strong similarity to subtelomeric encoded proteins + 0.027410 - 0.000030 ERG25 C-4 sterol methyl oxidase + 0.027254 - 0.000000 HSP12 heat shock protein + 0.025077 - 0.000094 YNL269W hypothetical protein + 0.024389 - 0.000112 PRY3 strong similarity to the plant PR-1 class of pathogen related proteins + 0.024191 - 0.000077 YPR053C questionable ORF + 0.024068 - 0.000124 BUD19 questionable ORF + 0.023150 - 0.000326 GIN4 ser/thr protein kinase + 0.018279 - 0.000286 NUP170 nuclear pore protein + 0.000218 - 0.017978 MUC1 "extracellular alpha-1,4-glucan glucosidase" + 0.017733 - 0.000283 YAL053W "strong similarity to hypothetical proteins YOR365c,YGL139w,YPL221w" + 0.000071 - 0.016167 YNR067C similarity to beta-glucan-elicitor receptor - Glycine max + 0.000000 - 0.015532 FUS1 cell fusion protein Cluster 34: 10 genes TF NRG1 (2 / 68 20.00%) transcriptional repressor for glucose repression of STA1 gene expression YHL041W YKL177W + 0.000196 - 0.377816 YFL040W similarity to yeast glucose transport proteins + 0.000459 - 0.377133 YKL177W questionable ORF + 0.000412 - 0.377008 YHL041W weak similarity to Drosophila hypothetical protein 6 + 0.000198 - 0.376855 YHL049C strong similarity to subtelomeric encoded proteins + 0.376853 - 0.000197 YMR018W similarity to tetratricopeptide-repeat protein PAS10 + 0.000184 - 0.376778 YNL205C questionable ORF + 0.000078 - 0.376763 YHR155W strong similarity to Snf1p-interacting protein Sip3p + 0.000062 - 0.026334 YGL152C questionable ORF + 0.016213 - 0.000130 HSP12 heat shock protein + 0.000000 - 0.015940 ARG1 argininosuccinate synthetase Cluster 35: 13 genes TF SWI5 (2 / 84 15.38%) transcription factor YFL063W YFR017C TF NRG1 (2 / 68 15.38%) transcriptional repressor for glucose repression of STA1 gene expression STL1 YFR017C TF YAP5 (2 / 81 15.38%) involved in transcription activation YFL063W YJL135W + 0.352840 - 0.000377 YFR017C hypothetical protein + 0.352772 - 0.000397 YFL063W strong similarity to subtelomeric encoded proteins + 0.352612 - 0.000295 YJL135W questionable ORF + 0.352387 - 0.000089 YDR048C questionable ORF + 0.351919 - 0.000000 DAN1 only expressed under anaerobic conditions + 0.351733 - 0.000259 STL1 member of the sugar permease family + 0.348466 - 0.000000 YOR338W similarity to YAL034c + 0.000000 - 0.317619 SEO1 suppressor of sulfoxyde ethionine resistance + 0.000000 - 0.125457 HAP5 CCAAT-binding factor subunit + 0.118910 - 0.000000 YPL276W identical to a region of YOR388c + 0.000000 - 0.023973 MHT1 weak similarity to M.leprae metH2 protein + 0.000000 - 0.018048 YML089C questionable ORF + 0.000000 - 0.016459 GTT2 glutathione S-transferase Cluster 36: 9 genes + 0.835162 - 0.002785 YIL102C strong similarity to YIL014c-a + 0.000000 - 0.533975 YNL028W questionable ORF + 0.000002 - 0.058570 ZRT1 high-affinity zinc transport protein + 0.041207 - 0.000000 YOR029W hypothetical protein + 0.000000 - 0.036621 HSP12 heat shock protein + 0.000000 - 0.027384 CHA1 L-serine/L-threonine deaminase + 0.023569 - 0.000633 YJL135W questionable ORF + 0.000000 - 0.022296 YRO2 strong similarity to HSP30 heat shock protein Yro1p + 0.000000 - 0.017459 CWP1 cell wall mannoprotein Cluster 37: 2 genes + 0.882326 - 0.000272 YHR087W weak similarity to PIR:T50363 hypothetical protein SPBC21C3.19 S.pombe + 0.000000 - 0.467885 HIS1 ATP phosphoribosyltransferase Cluster 38: 18 genes TF SWI5 (3 / 84 16.67%) transcription factor PIR3 YLR012C EGT2 TF ABF1 (3 / 251 16.67%) ARS-binding factor YIL032C YNL057W YNL119W TF PHO4 (2 / 54 11.11%) transcription factor YLR152C BOP2 TF MCM1 (2 / 73 11.11%) transcription factor of the MADS box family PIR3 YNL058C TF PHO2 (2 / 27 11.11%) homeodomain protein YLR152C YNL057W TF ARO80 (2 / 28 11.11%) positive transcription regulator of ARO9 and ARO10 ARO10 ARO9 + 0.571522 - 0.000229 PRP2 RNA-dependent ATPase of DEAH box family + 0.571408 - 0.000212 YHR155W strong similarity to Snf1p-interacting protein Sip3p + 0.536314 - 0.000160 YLR012C hypothetical protein + 0.000000 - 0.182801 CMD1 calmodulin + 0.000046 - 0.061711 YNL119W weak similarity to M.jannaschii hypothetical protein MJ1257 + 0.036540 - 0.000000 ARO10 "similarity to Pdc6p, Thi3p and to pyruvate decarboxylases" + 0.036156 - 0.000277 PIR3 member of the Pir1p/Pir2p/Pir3p family + 0.033567 - 0.000005 YNL057W questionable ORF + 0.030488 - 0.000000 YNL058C similarity to YIL117c + 0.029174 - 0.000000 ARO9 aromatic amino acid aminotransferase II + 0.018738 - 0.000000 YHR209W similarity to hypothetical protein YER175c + 0.017928 - 0.000000 BOP2 hypothetical protein + 0.000000 - 0.016936 YNR067C similarity to beta-glucan-elicitor receptor - Glycine max + 0.016679 - 0.000000 YJL086C questionable ORF + 0.000271 - 0.016286 EGT2 cell-cycle regulation protein + 0.015686 - 0.000000 VTH1 "strong similarity to Vth2p and Pep1p, potential membrane glycoprotein" + 0.015546 - 0.000000 YLR152C similarity to YOR3165w and YNL095c + 0.000000 - 0.015445 YIL032C hypothetical protein Cluster 39: 10 genes TF HAL9 (2 / 16 20.00%) transcriptional activator of ENA1 PHM7 YOL085C TF SUM1 (2 / 48 20.00%) suppressor of SIR mutations DAL1 STE3 + 0.398726 - 0.000323 PHM7 similarity to A.thaliana hyp1 protein + 0.398622 - 0.000000 STR3 strong similarity to Emericella nidulans and similarity to other cystathionine beta-lyase and Cys3p + 0.000173 - 0.398549 DAL1 allantoinase + 0.000287 - 0.398481 YOL085C hypothetical protein + 0.000000 - 0.397995 YAL064W hypothetical protein + 0.394268 - 0.000136 YNR071C strong similarity to UDP-glucose 4-epimerase Gal10p + 0.199025 - 0.000071 RNR3 "ribonucleotide reductase, repair inducible large subunit" + 0.071781 - 0.000000 STE3 pheromone a-factor receptor + 0.000000 - 0.060659 YLL055W similarity to Dal5p + 0.021462 - 0.000000 HSP12 heat shock protein Cluster 41: 13 genes TF CIN5 (2 / 129 15.38%) transcriptional activator MHT1 YOL157C TF SMP1 (2 / 55 15.38%) MADS-box transcription factor YKR105C YLR465C + 0.314465 - 0.000125 YCR001W weak similarity to chloride channel proteins + 0.314445 - 0.000000 AAR2 A1 cistron splicing factor + 0.000000 - 0.314404 TGL2 triacylglycerol lipase + 0.000150 - 0.314340 TEM1 GTP-binding protein of the RAS superfamily + 0.314292 - 0.000000 SEO1 suppressor of sulfoxyde ethionine resistance + 0.000000 - 0.314123 HAP5 CCAAT-binding factor subunit + 0.310525 - 0.000131 YKR105C strong similarity to Sge1p and hypothetical protein YCL069w + 0.309875 - 0.000146 YOL157C strong similarity to alpha-glucosidases + 0.000130 - 0.306353 YGL239C questionable ORF + 0.306279 - 0.000110 YNR071C strong similarity to UDP-glucose 4-epimerase Gal10p + 0.155469 - 0.000000 MHT1 weak similarity to M.leprae metH2 protein + 0.000000 - 0.035173 ECM2 involved in cell wall biogenesis and architecture + 0.029556 - 0.000000 YLR465C questionable ORF Cluster 42: 7 genes + 0.000315 - 0.696046 YJR078W "similarity to mammalian indoleamine 2,3-dioxygenase" + 0.695580 - 0.000368 UGX2 hypothetical protein + 0.000000 - 0.141980 SOR1 sorbitol dehydrogenase + 0.000000 - 0.034220 FUS1 cell fusion protein + 0.000000 - 0.025308 FYV11 similarity to repeat structures in a Plasmodium falciparum protein (MESA) that binds human erythrocyte protein 4.1. + 0.023950 - 0.000000 SEO1 suppressor of sulfoxyde ethionine resistance + 0.016083 - 0.000000 YGR107W questionable ORF Cluster 43: 21 genes TF PDR1 (4 / 53 19.05%) transcription factor YBL112C NOP14 YDR543C YLR465C TF YAP5 (4 / 81 19.05%) involved in transcription activation YBL112C EXO84 YDR543C YLR465C TF ABF1 (4 / 251 19.05%) ARS-binding factor YCR001W UBP1 YKR029C RSM19 TF RGM1 (3 / 21 14.29%) transcriptional repressor protein YBL112C YDR543C YLR465C TF HAP4 (3 / 57 14.29%) CCAAT-binding factor subunit YDR543C COX12 YLR465C TF SKN7 (2 / 83 9.52%) transcription factor with similarity to Hsf1p KNS1 AFG2 TF GAL4 (2 / 31 9.52%) transcription factor YBL112C YDR543C TF SWI5 (2 / 84 9.52%) transcription factor YDR543C YLR346C TF HSF1 (2 / 48 9.52%) heat shock transcription factor BUD7 YOR300W TF IME4 (2 / 33 9.52%) positive transcription factor for IME2 EXO84 YLR346C + 0.346515 - 0.000000 NOP14 nuclear and nucleolar protein with possible role in ribosome biogenesis + 0.346355 - 0.000000 YLR346C weak similarity to YGR035c + 0.345818 - 0.000000 KNS1 ser/thr protein kinase + 0.344056 - 0.000218 BUD7 involved in bud-site selection + 0.344015 - 0.000159 COX12 "cytochrome-c oxidase, subunit VIB" + 0.343944 - 0.000104 TRF4 topoisomerase I-related protein + 0.000207 - 0.342934 YOR300W questionable ORF + 0.256023 - 0.000000 YBL112C strong similarity to subtelomeric encoded proteins + 0.253904 - 0.000000 PRR2 strong similarity to putative protein kinase NPR1 + 0.112632 - 0.000000 YDR543C strong similarity to subtelomeric encoded proteins + 0.000000 - 0.068632 UBP1 ubiquitin-specific protease + 0.065323 - 0.000000 RSM19 strong similarity to Mycoplasma ribosomal protein S19 + 0.057746 - 0.000000 YKR029C similarity to YJL105w and Lentinula MFBA protein + 0.054549 - 0.000000 MLH2 "similarity to human mutL protein homolog, mouse PMS2, Mlh1p and Pms1p" + 0.049262 - 0.000000 TDH2 glyceraldehyde-3-phosphate dehydrogenase 2 + 0.039488 - 0.000000 EXO84 exocyst protein essential for secretion + 0.032588 - 0.000000 YOL157C strong similarity to alpha-glucosidases + 0.030638 - 0.000000 AFG2 strong similarity to CDC48 + 0.028179 - 0.000329 YLR465C questionable ORF + 0.021713 - 0.000000 YCR001W weak similarity to chloride channel proteins + 0.000000 - 0.016765 FUS1 cell fusion protein Cluster 44: 9 genes TF SWI6 (2 / 84 22.22%) transcription factor YGL239C PCL1 + 0.000181 - 0.502545 YML089C questionable ORF + 0.487042 - 0.000197 GTT2 glutathione S-transferase + 0.000000 - 0.487020 AAR2 A1 cistron splicing factor + 0.000214 - 0.484151 YGL239C questionable ORF + 0.160240 - 0.000072 YGL074C questionable ORF + 0.083888 - 0.000042 YPR203W strong similarity to subtelomeric encoded proteins + 0.046471 - 0.000000 YJL086C questionable ORF + 0.044095 - 0.000262 PCL1 "cyclin, G1/S-specific" + 0.020297 - 0.000000 SPS2 sporulation-specific protein Cluster 45: 20 genes TF PHD1 (3 / 74 15.00%) transcription factor MSN4 HXT13 RGS2 TF SWI6 (2 / 84 10.00%) transcription factor (MLP1) YOL160W TF PHO4 (2 / 54 10.00%) transcription factor YJR098C YOL160W TF GAL4 (2 / 31 10.00%) transcription factor GAL10 GAL3 + 0.703020 - 0.000289 (MLP1) strong similarity to ser/thr-specific protein kinase Slt2p + 0.000000 - 0.660024 YPL276W identical to a region of YOR388c + 0.188135 - 0.000297 RNR3 "ribonucleotide reductase, repair inducible large subunit" + 0.076320 - 0.000000 USV1 "similarity to Rgm1p, weak similarity to transcription factors" + 0.006355 - 0.035159 CWP1 cell wall mannoprotein + 0.032102 - 0.000000 MTH1 repressor of hexose transport genes + 0.028985 - 0.000000 MSN4 transcriptional activator + 0.027086 - 0.000144 RGS2 negative regulator of glucose-induced cAMP signaling pathway + 0.000000 - 0.026698 GAL10 UDP-glucose 4-epimerase + 0.000066 - 0.026684 APG7 component of the autophagic system + 0.000001 - 0.026128 DDR48 heat shock protein + 0.000116 - 0.025475 MMS21 DNA repair protein + 0.022664 - 0.000193 HXT13 high-affinity hexose transporter + 0.021809 - 0.000206 YJR098C weak similarity to Bacillus licheniformis esterase + 0.021383 - 0.000188 NCE103 involved in non-classical protein export pathway + 0.020065 - 0.000134 YBR238C strong similarity to general chromatin factor Spt16p + 0.019996 - 0.000000 YKR075C weak similarity to negative regulator Reg1p + 0.018025 - 0.000000 GAL3 galactokinase + 0.000419 - 0.017942 ADA2 general transcriptional adaptor or co-activator + 0.016980 - 0.000141 YOL160W hypothetical protein Cluster 46: 9 genes TF SWI6 (2 / 84 22.22%) transcription factor PCL2 YJR030C + 0.985123 - 0.000236 PCL2 "cyclin, G1/S-specific" + 0.000669 - 0.125173 YHR130C weak similarity to T.brucei H+-transporting ATP synthase + 0.000000 - 0.058072 YOR024W hypothetical protein + 0.000331 - 0.049004 YJR030C similarity to hypothetical protein YJL181w + 0.000000 - 0.032730 PMT6 putative mannosyltransferase + 0.000124 - 0.031634 BUB2 cell cycle arrest protein + 0.000000 - 0.019956 YCR001W weak similarity to chloride channel proteins + 0.000068 - 0.016079 STB6 SIN3 binding protein + 0.015711 - 0.000000 ERG1 squalene monooxygenase Cluster 50: 9 genes + 0.000000 - 0.571000 STR3 strong similarity to Emericella nidulans and similarity to other cystathionine beta-lyase and Cys3p + 0.000316 - 0.570627 YMR082C hypothetical protein + 0.000256 - 0.570344 YMC2 mitochondrial carrier protein (MCF) + 0.089520 - 0.000120 APL3 "AP-2 complex subunit, alpha-adaptin, 113 KD" + 0.029159 - 0.000321 GPR1 G-protein coupled receptor + 0.000002 - 0.024570 KAR5 nuclear fusion protein + 0.021951 - 0.000000 YML089C questionable ORF + 0.000102 - 0.017302 RAD6 E2 ubiquitin-conjugating enzyme + 0.000000 - 0.017138 PRM1 similarity to S. pombe coiled-coil protein of unknown function Number of clusters with significant GO annotations: 20 Average number of significant GO annotations per cluster: 11.200000 Average number of TFs per cluster controlling >= 2 genes (clusters with significant GO annotations): 14.500000 Average number of TFs per cluster controlling >= 2 genes (clusters with no significant GO annotations): 4.700000 Average number of TFs per cluster controlling >= 2 genes: 8.620000 Average fraction of cluster genes controlled by TFs: 0.462202 n_cl_go = 20 cl_go_n_tf = Columns 1 through 15 0 7 4 6 20 10 1 7 3 42 5 0 2 42 3 Columns 16 through 20 11 75 3 6 43 cl_go_n_g = Columns 1 through 15 2 18 12 19 38 18 9 16 14 137 17 7 9 141 10 Columns 16 through 20 24 482 18 15 144 cl_go_n_gtf = Columns 1 through 15 0 7 7 11 29 13 2 13 5 118 13 0 6 122 7 Columns 16 through 20 17 456 11 8 124 cl_go_n_go = Columns 1 through 15 21 4 3 8 2 2 1 13 1 12 11 1 13 12 22 Columns 16 through 20 1 50 26 1 20 n_cl_nogo = 30 cl_nogo_n_tf = Columns 1 through 15 8 12 2 16 1 0 0 15 16 2 0 1 8 5 5 Columns 16 through 30 0 20 1 3 0 0 6 2 2 0 10 1 4 1 0 cl_nogo_n_g = Columns 1 through 15 28 24 10 41 7 5 5 42 42 6 4 7 13 14 15 Columns 16 through 30 5 42 10 13 9 2 18 10 13 7 21 9 20 9 9 cl_nogo_n_gtf = Columns 1 through 15 20 19 4 33 2 0 0 33 33 4 0 2 8 9 5 Columns 16 through 30 0 28 2 4 0 0 11 4 4 0 15 2 8 2 0 mean_n_genes_per_cluster = 32.2000